{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:14:44Z","timestamp":1758820484098,"version":"3.38.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction The impact of antipsychotic use on weight gain and eating\n                    disorder-related psychopathology in adult inpatients with anorexia nervosa (AN)\n                    is unclear.<\/jats:p><jats:p>\n          Methods Consecutively hospitalized adults with AN were retrospectively\n                    analyzed. Co-primary outcomes were body mass index (BMI) and weekly weight\n                    change. Secondary outcomes were Eating Disorder Inventory-2 (EDI-2) subscale\n                    scores \u2018drive for thinness\u2019 and \u2018body dissatisfaction\u2019. Admission-to-discharge\n                    changes were compared in patients continuing pre-admission antipsychotics\n                    (APcont), starting antipsychotics (APnew) and patients without\n                    psychopharmacotherapy (noMed) using linear mixed models. Sensitivity analyses\n                    were conducted in subgroups matched for age, length of stay, baseline BMI and\n                    baseline EDI-2 scores. Subgroups were also compared regarding BMI trajectories,\n                    using non-linear growth curve models. Within-group analyses compared weight gain\n                    before vs. after the median antipsychotic onset week.<\/jats:p><jats:p>\n          Results Of 775 adult inpatients (mean length of stay\u2009=103.5\u00b148.0 days),\n                    21.7% received antipsychotics (APcont\u2009=7.7%; APnew=13.9%), i.\u2009e., olanzapine\n                    (n=127, dose\u2009=5.5\u00b13.1\u2009mg\/day) or quetiapine (n=41, dose=100.0\u00b197.7\u2009mg\/day),\n                    while 78.3% did not receive any medication. Comparing all three groups, a\n                    significant time\u00d7group interaction was found for noMed and APnew vs. APcont\n                        (p=0.011), but this effect disappeared when comparing matched\n                    subgroups. However, in matched subgroups (n=54 each) APnew showed steeper weight\n                    gain vs. APcont both overall (p=0.011) and after median antipsychotic\n                    initiation (5.8\u00b15.0 weeks) (p\u22640.001). No significant group differences\n                    emerged in EDI-2 subscale scores.<\/jats:p><jats:p>\n          Discussion In this naturalistic study, 22% of adult inpatients received\n                    antipsychotics. However, neither weight gain nor AN-related psychopathology\n                    changed differently in patients treated with vs. without antipsychotics. Newly\n                    initiated antipsychotic treatment vs. continuation from pre-admission had better\n                    weight gain outcomes.<\/jats:p>","DOI":"10.1055\/a-2436-9552","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:02:54Z","timestamp":1732060974000},"page":"80-87","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Antipsychotic Medications on Weight Gain and Eating\n                    Disorder-Related Psychopathology in Adult Inpatients with Anorexia\n                    Nervosa"],"prefix":"10.1055","volume":"58","author":[{"given":"Tabea","family":"Bauman","sequence":"additional","affiliation":[{"name":"Schoen Clinic Roseneck, Prien am Chiemsee, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Kolar","sequence":"additional","affiliation":[{"name":"Clinical Child and Adolescent Psychology and Psychotherapy, Department\n                    of Psychology, University of Regensburg, Regensburg, Germany"},{"name":"Department of Psychiatry and Psychotherapy,\n                    Ludwig-Maximilians-University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry,\n                    Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Department of Psychiatry and Molecular Medicine, Donald and Barbara\n                    Zucker School of Medicine at Hofstra\/Northwell, Hempstead, New York,\n                    USA"},{"name":"Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New\n                    York, USA"},{"name":"Center for Psychiatric Neuroscience, Feinstein Institute for Medical\n                    Research, Manhasset, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry,\n                    Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Voderholzer","sequence":"additional","affiliation":[{"name":"Schoen Clinic Roseneck, Prien am Chiemsee, Germany"},{"name":"Department of Psychiatry and Psychotherapy,\n                    Ludwig-Maximilians-University Munich, Munich, Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Hospital of\n                    Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41380-021-01161-7","article-title":"Age at onset of mental 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Disord"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2436-9552.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:02:12Z","timestamp":1741305732000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2436-9552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":42,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2025,3,6]]},"published-print":{"date-parts":[[2025,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2436-9552","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"type":"print","value":"0176-3679"},{"type":"electronic","value":"1439-0795"}],"subject":[],"published":{"date-parts":[[2024,11,19]]}}}