{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T22:18:20Z","timestamp":1776637100570,"version":"3.51.2"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82000443"],"award-info":[{"award-number":["82000443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82030016"],"award-info":[{"award-number":["82030016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170282"],"award-info":[{"award-number":["82170282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82200320"],"award-info":[{"award-number":["82200320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82230011"],"award-info":[{"award-number":["82230011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                  Background\u2003The occurrence and development of ST-segment elevation myocardial infarction (STEMI) are accompanied by coronary atherothrombosis and occlusion, and immune responses play prominent roles in their pathogeneses. However, the causes of atherothrombosis remain elusive, and a comprehensive study of T cell-mediated immune responses in coronary thrombi from STEMI patients is lacking.<\/jats:p><jats:p>\n                  Objectives\u2003The aim of this study was to determine the heterogeneity and clonality of CD3+ T lymphocytes in STEMI patients at the single-cell level.<\/jats:p><jats:p>\n                  Methods\u2003Paired single-cell RNA and T cell receptor (TCR) sequencing was performed on CD3+ T lymphocytes in the coronary thrombi and peripheral blood of STEMI patients, as well as the blood from control subjects without coronary artery disease (CAD).<\/jats:p><jats:p>\n                  Results\u2003Compared with those in the peripheral blood of STEMI patients, the activation, cytotoxicity, proinflammatory, and prothrombotic characteristics of CD3+ T lymphocytes in coronary thrombi were decreased, and the clonality of CD3+ T cells was increased. Compared with those from non-CAD controls, T lymphocytes from STEMI patients exhibited an upregulation of genes related to recent TCR engagement, suggesting antigen-specific stimulation in STEMI. Antigen specificity prediction using an algorithm indicated the probability of T cells from different patients binding to similar antigens for clonal expansion during STEMI.<\/jats:p><jats:p>\n                  Conclusion\u2003This study provides a basis for exploring the cellular heterogeneity of CD3+ T lymphocytes in the coronary thrombi and peripheral blood of STEMI patients. Identifying the precise adaptive immune mechanisms driving atherothrombosis may lead to innovative therapies that selectively target the aberrant immune response, resulting in more effective treatments for STEMI.<\/jats:p>","DOI":"10.1055\/a-2437-6111","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:39:49Z","timestamp":1731026389000},"page":"697-712","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of CD3+ T Lymphocytes in Human Coronary Thrombi with ST-segment Elevation Myocardial Infarction"],"prefix":"10.1055","volume":"125","author":[{"given":"Muyang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological 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Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union 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Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"},{"name":"Hubei Key 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Liuzzo","year":"2000","journal-title":"Circulation"},{"issue":"19","key":"ref14","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.jacc.2016.08.036","article-title":"Adaptive immunity dysregulation in acute coronary syndromes: from cellular and molecular basis to clinical implications","volume":"68","author":"D Flego","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2017.76","article-title":"Single-cell RNA sequencing to explore immune cell heterogeneity","volume":"18","author":"E Papalexi","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.117.312513","article-title":"Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry","volume":"122","author":"H Winkels","year":"2018","journal-title":"Circ 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Lin","year":"2019","journal-title":"JCI Insight"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41591-019-0590-4","article-title":"Single-cell immune landscape of human atherosclerotic plaques","volume":"25","author":"D M Fernandez","year":"2019","journal-title":"Nat Med"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1161\/CIRCRESAHA.120.316770","article-title":"Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics","volume":"127","author":"M AC Depuydt","year":"2020","journal-title":"Circ Res"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/CIRCRESAHA.121.320090","article-title":"Human coronary plaque T cells are clonal and cross-react to virus and self","volume":"130","author":"R R Chowdhury","year":"2022","journal-title":"Circ 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Ramaiola","year":"2015","journal-title":"Eur Heart J"},{"issue":"07","key":"ref26","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"T Stuart","year":"2019","journal-title":"Cell"},{"issue":"05","key":"ref27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"A Butler","year":"2018","journal-title":"Nat Biotechnol"},{"issue":"7735","key":"ref28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","article-title":"Lineage tracking reveals dynamic relationships of T cells in colorectal cancer","volume":"564","author":"L Zhang","year":"2018","journal-title":"Nature"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1136\/annrheumdis-2021-220209","article-title":"Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis","volume":"80","author":"A M Gaydosik","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"D Aran","year":"2019","journal-title":"Nat Immunol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"e25734","DOI":"10.1371\/journal.pone.0025734","article-title":"RANTES\/CCL5 and risk for coronary events: results from the MONICA\/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies","volume":"6","author":"C Herder","year":"2011","journal-title":"PLoS One"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1160\/TH10-10-0662","article-title":"CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke","volume":"105","author":"M Mirabelli-Badenier","year":"2011","journal-title":"Thromb Haemost"},{"issue":"05","key":"ref33","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jth.14759","article-title":"Cytokine and chemokine regulation of venous thromboembolism","volume":"18","author":"M Y Najem","year":"2020","journal-title":"J Thromb Haemost"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"867189","DOI":"10.3389\/fimmu.2022.867189","article-title":"The era of cytotoxic CD4 T cells","volume":"13","author":"M Cenerenti","year":"2022","journal-title":"Front Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7554\/eLife.30496","article-title":"The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes","volume":"7","author":"Y Serroukh","year":"2018","journal-title":"eLife"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijcard.2017.02.011","article-title":"Serum CXCL10 and CXCL12 chemokine levels are associated with the severity of coronary artery disease and coronary artery occlusion","volume":"233","author":"V Tavakolian Ferdousie","year":"2017","journal-title":"Int J Cardiol"},{"issue":"17","key":"ref37","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1182\/blood.2020010140","article-title":"Targeting platelet-derived CXCL12 impedes arterial thrombosis","volume":"139","author":"J Leberzammer","year":"2022","journal-title":"Blood"},{"issue":"07","key":"ref38","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"M Dominguez-Villar","year":"2018","journal-title":"Nat Immunol"},{"key":"ref39","first-page":"616","article-title":"Adaptive memory of human NK-like CD8+ T-cells to aging, and viral and tumor antigens","volume":"7","author":"M L Pita-L\u00f3pez","year":"2016","journal-title":"Front Immunol"},{"issue":"07","key":"ref40","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cell.2020.10.048","article-title":"Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia","volume":"183","author":"J Wang","year":"2020","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gkx760","article-title":"VDJdb: a curated database of T-cell receptor sequences with known antigen specificity","volume":"46","author":"M Shugay","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"ref42","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1093\/bioinformatics\/btx286","article-title":"McPAS-TCR: 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Med"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1093\/infdis\/jis597","article-title":"Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study","volume":"206","author":"C Warren-Gash","year":"2012","journal-title":"J Infect Dis"},{"issue":"03","key":"ref47","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/08916934.2014.1003641","article-title":"Vaccination to modulate atherosclerosis","volume":"48","author":"T Kimura","year":"2015","journal-title":"Autoimmunity"},{"issue":"03","key":"ref48","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.exger.2007.11.009","article-title":"T-cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T-cell receptor repertoire","volume":"43","author":"A Rossmann","year":"2008","journal-title":"Exp 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