{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:19:30Z","timestamp":1744949970512,"version":"3.40.4"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The gold standard for ruling out distant metastases as part of primary staging in lung cancer is whole-body 18F-FDG-PET\/CT, but this method is resource-intensive. Recent evidence suggests that examining only the thorax and upper abdomen may be sufficient 1\n            2\n            3. If a limited 18F-FDG-PET\/CT approach proves effective for proper staging, it could lead to quicker examinations and reduced radiation exposure. This study aimed to determine whether limited 18F-FDG-PET\/CT is adequate for the primary staging of lung cancer.<\/jats:p><jats:p>In this study, a retrospective analysis of 161 patients (87 men, 74 women; age range 31\u201388 y) with recent or suspected lung cancer who had undergone a whole-body 18F-FDG-PET\/CT examination for primary staging at our clinic between 2018 and 2022 was conducted. None of these patients showed evidence of extrathoracic metastases before the 18F-FDG-PET\/CT examination. The images were divided into three regions: \u201chead-neck\u201d (HN), \u201cthorax-upper abdomen\u201d (TUA), and \u201clower abdomen-hip\u201d (LAH). TNM staging based on the HN plus TUA region was compared with TNM staging based on the whole body.<\/jats:p><jats:p>Among the 161 subjects, 7 (4%) showed malignancy-suspect lesions in HN, 110 (68%) in TUA and 7 (4%) had suspected distant metastases in LAH. The TNM staging based on HN plus TUA corresponded to TNM staging based on the whole body in 161 (100%) examinations. This finding aligns with similar results in previous literature.<\/jats:p><jats:p>\n            18F-FDG-PET\/CT limited to HN and TUA yielded accurate staging in all cases. Adopting this method could facilitate the examination and correct staging of more individuals, reducing exam waiting times and physician reporting time and minimising radiation exposure.<\/jats:p>","DOI":"10.1055\/a-2438-7278","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T01:10:43Z","timestamp":1731373843000},"page":"150-155","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of whole-body 18F-FDG-PET\/CT with 18F-FDG-PET\/CT limited to skull base to upper abdomen for primary staging of lung cancer \u2013 a retrospective explorative analysis"],"prefix":"10.1055","volume":"64","author":[{"given":"Lukas","family":"Schulz","sequence":"additional","affiliation":[{"name":"2. Medizinische Abteilung mit Pneumologie und Karl-Landsteiner Institut f\u00fcr Lungenforschung und pneumologische Onkologie, Wiener Gesundheitsverbund Klinik Ottakring, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg-Christian","family":"Funk","sequence":"additional","affiliation":[{"name":"2. Medizinische Abteilung mit Pneumologie und Karl-Landsteiner Institut f\u00fcr Lungenforschung und pneumologische Onkologie, Wiener Gesundheitsverbund Klinik Ottakring, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Kirchbacher","sequence":"additional","affiliation":[{"name":"2. Medizinische Abteilung mit Pneumologie und Karl-Landsteiner Institut f\u00fcr Lungenforschung und pneumologische Onkologie, Wiener Gesundheitsverbund Klinik Ottakring, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Egger","sequence":"additional","affiliation":[{"name":"2. Medizinische Abteilung mit Pneumologie und Karl-Landsteiner Institut f\u00fcr Lungenforschung und pneumologische Onkologie, Wiener Gesundheitsverbund Klinik Ottakring, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nino","family":"M\u00fcser","sequence":"additional","affiliation":[{"name":"2. Medizinische Abteilung mit Pneumologie und Karl-Landsteiner Institut f\u00fcr Lungenforschung und pneumologische Onkologie, Wiener Gesundheitsverbund Klinik Ottakring, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siroos","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Nuklearmedizin mit PET-Zentrum, Wiener Gesundheitsverbund Klinik Ottakring, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e0160539","DOI":"10.1371\/journal.pone.0160539","article-title":"FDG-PET\/CT Limited to the Thorax and Upper Abdomen for Staging and Management of Lung Cancer","volume":"11","author":"AI Arens","year":"2016","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1378\/chest.126.3.755","article-title":"Does whole-body 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography have an advantage over thoracic positron emission tomography for staging patients with lung cancer?","volume":"126","author":"SL Aquino","year":"2004","journal-title":"Chest"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1177\/0284185113476021","article-title":"Value of true whole-body FDG-PET\/CT scanning protocol in oncology: optimization of its use based on primary diagnosis","volume":"54","author":"R Sebro","year":"2013","journal-title":"Acta Radiol"},{"first-page":"87","volume-title":"S3-Leitlinie Pr\u00e4vention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms. 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A short review","volume":"38","author":"RC Delgado Bolton","year":"2019","journal-title":"Rev Esp Med Nucl Imagen Mol (Engl Ed)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2174\/1874471013666191223153755","article-title":"FDG PET\/CT in the Staging of Lung Cancer","volume":"13","author":"M Farsad","year":"2020","journal-title":"Curr Radiopharm"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1200\/jco.2004.04.126","article-title":"Randomized controlled trial of the role of positron emission tomography in the management of stage I and II non-small-cell lung cancer","volume":"22","author":"RC Viney","year":"2004","journal-title":"J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"40s","DOI":"10.1183\/09031936.02.00270802","article-title":"Computed tomography in staging for lung cancer","volume":"35","author":"JA Verschakelen","year":"2002","journal-title":"Eur Respir J Suppl"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13550-017-0272-5.","article-title":"Effective dose estimation for oncological and neurological PET\/CT procedures","volume":"7","author":"JM Mart\u00ed-Climent","year":"2017","journal-title":"EJNMMI research"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/bf01068419","article-title":"A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability","volume":"15","author":"DJ Schuirmann","year":"1987","journal-title":"J Pharmacokinet Biopharm"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/(sici)1097-0258(19980430)17:8<873::aid-sim779>3.0.co;2-i","article-title":"Interval estimation for the difference between independent proportions: comparison of eleven methods","volume":"17","author":"RG Newcombe","year":"1998","journal-title":"Stat Med"}],"container-title":["Nuklearmedizin - NuclearMedicine"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2438-7278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T22:46:50Z","timestamp":1744930010000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2438-7278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":11,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2025,4,17]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2438-7278","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"type":"print","value":"0029-5566"},{"type":"electronic","value":"2567-6407"}],"subject":[],"published":{"date-parts":[[2024,11,11]]}}}