{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T04:27:20Z","timestamp":1743740840568,"version":"3.40.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002 The aim of this study was to evaluate the maternal\n                    epidemiological profile for gastroschisis as well as to assess whether the\n                    presence of meconium at birth was associated with adverse neonatal outcomes.<\/jats:p><jats:p>\n          Methods\u2002 This was a retrospective observational cohort study that included\n                    52 neonates with gastroschisis whose mothers had delivery at our service. The\n                    variables observed were the following: 1) socio-demographic data, 2)\n                    ultrasonographic data, 3) birth data, and 4) neonatal outcomes. Simple\n                    (univariate) and multiple (multivariate) logistic regression models were used to\n                    examine the influence of meconium on neonatal outcomes.<\/jats:p><jats:p>\n          Results\u2002 Mean maternal age and body mass index (BMI) of the pregnant women\n                    were 21.9 years and 23.3 kg\/m2, respectively. There was a similarity between\n                    mixed (50%) and white (48.1%) races, and 27.7% (13) reported to use an oral\n                    contraceptive (OC). Mean birth weight was 2,386.9 grams, and 24 of the neonates\n                    (46.2%) were premature (&lt;37 weeks). The majority of neonates had neonatal\n                    sepsis (40.4%) and 39 were admitted to the neonatal intensive care unit with a\n                    median length of stay of 31 days. Forty neonates required mechanical\n                    ventilation, with a median duration of 5 days. Primary closure was achieved in\n                    50% (26) of cases. Although not significant and with low precision, the point\n                    estimate suggested that the presence of meconium at birth, on average, reduced\n                    the chance of primary closure (OR=0.26, CI 95% [0.06; 1.16], p=0.077).<\/jats:p><jats:p>\n          Conclusion\u2002 Pregnant women with gastroschisis fetuses were more likely to\n                    be young, primigravida, with a normal BMI, white or mixed, and with a history of\n                    OC use. There was no evidence of an association between the presence of meconium\n                    at birth and adverse perinatal outcomes.<\/jats:p>","DOI":"10.1055\/a-2442-7557","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:39:23Z","timestamp":1731371963000},"page":"108-115","source":"Crossref","is-referenced-by-count":0,"title":["Fetal Gastroschisis: Maternal Epidemiologic Profile and Influence of\n                    Possible Risk Factors on Neonatal Outcomes"],"prefix":"10.1055","volume":"229","author":[{"given":"Thalita Di\u00f3genes","family":"Muniz","sequence":"additional","affiliation":[{"name":"Obstetrics, Universidade Federal de Sao Paulo Escola\n                    Paulista de Medicina, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliam Cristine","family":"Rolo","sequence":"additional","affiliation":[{"name":"Obstetrics, Universidade Federal de Sao Paulo Escola\n                    Paulista de Medicina, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Obstetrics, Universidade Federal de Sao Paulo Escola\n                    Paulista de Medicina, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1053\/j.sempedsurg.2018.08.006","article-title":"Advances in prenatal and perinatal diagnosis and management of\n                    gastroschisis","volume":"27","author":"M C Oakes","year":"2018","journal-title":"Semin Pediatr Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1080\/14767058.2021.1909563","article-title":"Gastroschisis: a systematic review of diagnosis, prognosis and treatment","volume":"35","author":"R G Ferreira","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jpedsurg.2013.11.052","article-title":"Anomalies associated with gastroschisis and omphalocele: Analysis of 2825 cases\n                    from the Texas Birth Defects Registry","volume":"49","author":"B Benjamin","year":"2014","journal-title":"J Pediatr Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/OGX.0000000000000344","article-title":"Gastroschisis: A review of management and outcomes","volume":"71","author":"R V O\u2019Connell","year":"2016","journal-title":"Obstet Gynecol Surv"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/jp.2017.171","article-title":"Predicting birth weight in fetuses with gastroschisis","volume":"38","author":"M N Zaki","year":"2018","journal-title":"J Perinatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/tera.1420500107","article-title":"A population-based study of gastroschisis: Demographic, pregnancy, and lifestyle\n                    risk factors","volume":"50","author":"C P Torfs","year":"1994","journal-title":"Teratology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1080\/14767058.2018.1433657","article-title":"An evaluation of nutritional and vasoactive stimulants as risk factors for\n                    gastroschisis: a pilot study","volume":"32","author":"J R Goodman","year":"2019","journal-title":"J Mater Fetal Neonatal Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.15585\/mmwr.mm6802a2","article-title":"Gastroschisis trends and ecologic link to opioid prescription rates \u2013 United\n                    States, 2006\u20132015","volume":"68","author":"T D Short","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/bdr2.1441","article-title":"A machine learning approach to investigate potential risk factors for\n                    gastroschisis in California","volume":"111","author":"K A Weber","year":"2019","journal-title":"Birth Defects Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/jpsu.2001.20004","article-title":"Gastroschisis: A plea for risk categorization","volume":"36","author":"K A Molik","year":"2001","journal-title":"J Pediatr Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/j.sempedsurg.2018.08.003","article-title":"Surgical strategies in complex gastroschisis","volume":"27","author":"S Emil","year":"2018","journal-title":"Semin Pediatr Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.jpedsurg.2018.03.011","article-title":"Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral\n                    center","volume":"53","author":"P Laje","year":"2018","journal-title":"J Pediatr Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1053\/j.sempedsurg.2018.08.007","article-title":"Risk stratification and outcome determinants in gastroschisis","volume":"27","author":"H Wissanji","year":"2018","journal-title":"Semin Pediatr Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000464245","article-title":"Sonographic markers in the prediction of fetal complex gastroschisis","volume":"43","author":"W S Andrade","year":"2018","journal-title":"Fetal Diagn Ther"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.3109\/14767058.2015.1090971","article-title":"Effect of antepartum meconium staining on perinatal and neonatal outcomes among\n                    pregnancies with gastroschisis","volume":"29","author":"A I Girsen","year":"2016","journal-title":"J Mater Fetal Neonatal Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.jpedsurg.2018.04.023","article-title":"Meconium-stained amniotic fluid as a predictor of poor outcomes in\n                    gastroschisis","volume":"53","author":"S M Koehler","year":"2018","journal-title":"J Pediatr Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9378(85)90298-4","article-title":"Estimation of fetal weight with the use of head, body, and femur measurements \u2013\n                    a prospective study","volume":"151","author":"F P Hadlock","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1148\/radiology.181.1.1887021","article-title":"In utero analysis of fetal growth: a sonographic weight standard","volume":"181","author":"F P Hadlock","year":"1991","journal-title":"Radiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.jpedsurg.2018.08.035","article-title":"Epidemiology of gastroschisis: A population-based study in California from 1995\n                    to 2012","volume":"53","author":"J E Anderson","year":"2018","journal-title":"J Pediatr Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.jpedsurg.2008.10.109","article-title":"Demographic and environmental risk factors for gastroschisis and omphalocele in\n                    the National Birth Defects Prevention Study","volume":"44","author":"T Mac Bird","year":"2009","journal-title":"J Pediatr Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-3016.2008.00990.x","article-title":"The joint effects of maternal prepregnancy body mass index and age on the risk\n                    of gastroschisis","volume":"23","author":"A M Siega-Riz","year":"2009","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/bdra.20238","article-title":"Interaction between maternal smoking and malnutrition in infant risk of\n                    gastroschisis","volume":"76","author":"P K Lam","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/jp.2016.99","article-title":"The epidemiology, prevalence and hospital outcomes of infants with\n                    gastroschisis","volume":"36","author":"R Allman","year":"2016","journal-title":"J Perinatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jpedsurg.2006.12.034","article-title":"Postnatal outcome in gastroschisis: effect of birth weight and gestational\n                    age","volume":"42","author":"P Charlesworth","year":"2007","journal-title":"J Pediatr Surg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12884-018-1867-1","article-title":"Complexity of gastroschisis predicts outcome: Epidemiology and experience in an\n                    Australian tertiary centre","volume":"18","author":"S J Melov","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/bdr2.1607","article-title":"Population-based birth defects data in the United States, 2012\u20132016: A focus on\n                    abdominal wall defects","volume":"111","author":"E B Stallings","year":"2019","journal-title":"Birth Defects Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/uog.8868","article-title":"Does gastric dilation predict adverse perinatal or surgical outcome in fetuses\n                    with gastroschisis?","volume":"37","author":"M A Alfaraj","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/ajps.AJPS_8_20","article-title":"Does meconium contaminated amniotic fluid affect intestinal wall thickness and\n                    functional outcome in patients with anterior abdominal wall defects?","volume":"19","author":"M Kapapa","year":"2022","journal-title":"African J Paediatr Surg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.jpedsurg.2018.04.023","article-title":"Meconium-stained amniotic fluid as a predictor of poor outcomes in\n                    gastroschisis","volume":"53","author":"S M Koehler","year":"2018","journal-title":"J Pediatr Surg"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2442-7557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T23:32:18Z","timestamp":1743723138000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2442-7557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":29,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2025,4,3]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2442-7557","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2024,11,11]]}}}