{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:35:06Z","timestamp":1758810906258,"version":"3.40.3"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do\n                        Estado de S\u00e3o Paulo","award":["FAPESP#2018\/16565-0"],"award-info":[{"award-number":["FAPESP#2018\/16565-0"]}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao\n                        Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"crossref","award":["FAPEMA BD-02488\/21"],"award-info":[{"award-number":["FAPEMA BD-02488\/21"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the association between the ACE (I\/D) polymorphism and\n                    strength phenotypes in Brazilian male handball players, considering their\n                    playing position. A total of 105 male junior handball players and 92 controls\n                    were evaluated. The ACE I\/D polymorphism was genotyped by conventional PCR\n                    followed by electrophoresis in agarose gel. All participants were\n                    anthropometrically evaluated and performed the standing long jump (SLJ) and\n                    medicine ball throw (MBT) tests. Athletes presented superior performance in the\n                    SLJ and MBT tests compared to the control group in all playing positions\n                    (p&lt;0.01). No significant differences were observed in genotype or allele\n                    frequencies when comparing athletes and controls or among playing positions.\n                    However, a significant difference was observed when comparing all athletes to\n                    controls using the over-dominant model (II+DD vs. ID; p=0.035). Additionally, ID\n                    athletes had better performance in the MBT than DD players (p=0.04), athletes\n                    with II+ID and II+DD genotypes exhibited superior performance in the SLJ test\n                    (p&lt;0.04), and ID athletes demonstrated increased height compared to II+DD\n                    counterparts (p=0.01). In conclusion, our data showed a potential association\n                    between ACE (I\/D) polymorphism and overall athletic predisposition in handball\n                    players, with no association with playing position.<\/jats:p>","DOI":"10.1055\/a-2443-9765","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T23:40:11Z","timestamp":1738194011000},"page":"296-301","source":"Crossref","is-referenced-by-count":1,"title":["Association between ACE (I\/D) polymorphism and physical performance\n                    in Brazilian handballers"],"prefix":"10.1055","volume":"46","author":[{"given":"Valmir Oliveira","family":"Silvino","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"},{"name":"Rede Nordeste de Biotecnologia (RENORBIO)\n                    post-graduation program, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro Soares","family":"Almeida","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo,\n                    Brazil"},{"name":"Faculdade Anhanguera de Guarulhos, Guarulhos, S\u00e3o Paulo,\n                    Brazil"},{"name":"Department of Obstetrics, Escola Paulista de Medicina,\n                    Universidade Federal de S\u00e3o Paulo Unifesp, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Matias","family":"Apaza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Escola Paulista de Medicina,\n                    Universidade Federal de S\u00e3o Paulo Unifesp, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayane Carvalho","family":"de Moura","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crislane de Moura","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cirley Pinheiro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"},{"name":"Rede Nordeste de Biotecnologia (RENORBIO)\n                    post-graduation program, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Sales","family":"Beleense","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Lu\u00eds Galan","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Antonio Pereira","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Physiology, Nucleus of\n                    Study in Physiology Applied to Performance and Health (NEFADS), Federal\n                    University of Piaui, Teresina, Brazil"},{"name":"Rede Nordeste de Biotecnologia (RENORBIO)\n                    post-graduation program, Teresina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref1","first-page":"125","article-title":"Evaluation of the morphological characteristics and motor skills in the national\n                    junior handball teams of Greece and Yugoslavia","volume":"46","author":"D Hatzimanouil","year":"2004","journal-title":"J Hum Mov Stud"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1600-0838.2006.00587.x","article-title":"Handball injuries during major international tournaments","volume":"17","author":"G Langevoort","year":"2007","journal-title":"Scand J Med Sci 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gene ACE I polymorphism I-D in athletes of different sports","volume":"26","year":"2020","journal-title":"Rev Bras Med do Esporte"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s004210050660","article-title":"Genetic variation in the renin-angiotensin system and athletic performance","volume":"82","author":"R Alvarez","year":"2000","journal-title":"Eur J Appl Physiol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1007\/s11010-023-04923-9","article-title":"The frequency of the ACE I\/D polymorphism in South America: A systematic review\n                    and meta-analysis","volume":"479","author":"R G Trevisano","year":"2024","journal-title":"Mol Cell Biochem"}],"container-title":["International Journal of Sports 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