{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:00:26Z","timestamp":1776898826627,"version":"3.51.2"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"NIH\/NINDS","award":["K23 NS111086"],"award-info":[{"award-number":["K23 NS111086"]}]},{"DOI":"10.13039\/100009633","name":"NIH\/NICHD","doi-asserted-by":"crossref","award":["K23 HD097254"],"award-info":[{"award-number":["K23 HD097254"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate cardiorespiratory status in preterm infants receiving dexmedetomidine using high-resolution physiologic data.<\/jats:p><jats:p>We analyzed preterm infants with continuous heart rate (HR) and oxygen saturation (SpO2) data for 24\u2009hours preceding and 48\u2009hours following dexmedetomidine initiation. Invasive arterial blood pressure (ABP), when available, was analyzed.<\/jats:p><jats:p>In 100 infants with a mean gestational age of 28 weeks and high baseline illness severity, mean HR decreased from 152 to 141 beats per minute while mean SpO2 increased from 91 to 93% in the 48\u2009hours after dexmedetomidine initiation (p\u2009&lt;\u20090.01). In 57 infants with continuous ABP monitoring, mean ABP increased from 40 to 42\u2009mm Hg (p\u2009=\u20090.01). Vasoactive-inotropic support increased before and after initiation.<\/jats:p><jats:p>We observed cardiorespiratory changes in critically ill preterm infants following dexmedetomidine initiation; mean HR decreased and mean SpO2 increased in the 48\u2009hours after initiation. In a subset, mean ABP increased along with vasoactive-inotropic support.<\/jats:p>","DOI":"10.1055\/a-2445-3010","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T01:17:12Z","timestamp":1729300632000},"page":"941-949","source":"Crossref","is-referenced-by-count":1,"title":["Cardiorespiratory Stability in Critically Ill Preterm Infants following Dexmedetomidine Initiation"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9580-4121","authenticated-orcid":false,"given":"Brynne A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville, 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