{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:17:40Z","timestamp":1774927060547,"version":"3.50.1"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"DZIF","doi-asserted-by":"crossref","award":["TTU 08.801"],"award-info":[{"award-number":["TTU 08.801"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Akademie f\u00fcr Infektionsmedizin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Eine wichtige Voraussetzung f\u00fcr die Sicherung einer rationalen Antibiotika-Verordnung ist die Verf\u00fcgbarkeit und Pr\u00fcfung von Verbrauchsdaten. Wir haben erstmals vor 10 Jahren solche Daten f\u00fcr Akutkrankenh\u00e4user in Deutschland vorgestellt und m\u00f6chten die Entwicklungen seither beschreiben.<\/jats:p><jats:p>Die j\u00e4hrlichen Antibiotika-Verordnungsmengen aus Akutkrankenh\u00e4usern wurden f\u00fcr den Zeitraum 2012\/13 bis 2021\/22 analysiert, dargestellt als Tagesdosen pro 100 Pflegetage, wobei die Tagesdosis-Definition speziell f\u00fcr den Krankenhausbereich adaptiert wurde (\u201erecommended daily dose\u201c, RDD). Zus\u00e4tzlich wurde eine Hochrechnung auf die Gesamtbev\u00f6lkerung unter Verwendung der seitens der WHO definierten Tagesdosen (\u201edefined daily doses\u201c, DDD) vorgenommen.<\/jats:p><jats:p>Die Antibiotika-Verbrauchsdichte in deutschen Akutkrankenh\u00e4usern ist im betrachteten 10-Jahres-Zeitraum nicht angestiegen. Sie betrug im Median im Jahre 2012\/13 insgesamt 41,9 RDD\/100 Pflegetage (n=169, Interquartilbereich 35\u201348 RDD\/100) im Vergleich zu 42,1 RDD\/100 im Jahre 2021\/22 (n=329, Interquartilbereich 35\u201348 RDD\/100). Auf die Bev\u00f6lkerung bezogen lag der Verbrauch 2021\/22 bei 1,85 DDD pro 1000 Bewohner und Tag. Die Verbrauchsdichte war in Universit\u00e4tskliniken (54,0 RDD\/100) signifikant h\u00f6her als in den nicht universit\u00e4ren Krankenh\u00e4usern unterschiedlicher Gr\u00f6\u00dfe, deren Verbrauchswerte sich nur wenig unterschieden (Mediane 39,8\u201344,0 RDD\/100). Penicilline wurden zunehmend h\u00e4ufiger (Anstieg des Anteils an allen Wirkstoffen +63%), Fluorchinolone (\u2013 54%) und Cephalosporine der ersten und zweiten Generation (\u2013 41%) seltener eingesetzt. Auf Intensivstationen war die Verordnungsdichte rund doppelt so hoch wie auf den Normalstationen. Hohe Verordnungsdichten wurden\n                        auch in universit\u00e4ren h\u00e4matologisch-onkologischen Abteilungen (Median 96,8 RDD\/100) und in Fachabteilungen f\u00fcr Urologie (Mediane 65,1\u201370,5 RDD\/100) und HNO-Heilkunde (Mediane 49,1\u201360,9 RDD\/100) beobachtet.<\/jats:p><jats:p>Bei gleichbleibender Antibiotika-Verordnungsdichte im Krankenhaus insgesamt gab es Verschiebungen im Spektrum der Wirkstoffgruppen, mit einer zunehmenden Bevorzugung von Penicillin-Derivaten. Auf die Bev\u00f6lkerung hochgerechnet lag der Verbrauch leicht oberhalb des europ\u00e4ischen Durchschnitts.<\/jats:p>","DOI":"10.1055\/a-2445-3397","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:14:06Z","timestamp":1732925646000},"page":"e1-e10","source":"Crossref","is-referenced-by-count":5,"title":["Antibiotikaanwendung 2012\/13 bis 2021\/22 in deutschen Akutkrankenh\u00e4usern"],"prefix":"10.1055","volume":"150","author":[{"given":"Winfried V.","family":"Kern","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Klinik f\u00fcr Innere Medizin II, Abteilung Infektiologie, Freiburg i.Br., GERMANY"},{"name":"Medizinische Fakult\u00e4t, Universit\u00e4t Freiburg,"},{"name":"Akademie f\u00fcr Infektionsmedizin, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Steib-Bauert","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Klinik 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