{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:28:53Z","timestamp":1758961733972,"version":"3.33.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Trauma-induced coagulopathy (TIC) is common in severely injured patients and is associated with significant morbidity and mortality.<\/jats:p><jats:p>\n          Method\u2003The association of two parameters of blood gas analysis (hemoglobin [Hb], base excess [BE]) with standard coagulation tests (SCTs) and rotational thrombelastometry (ROTEM) using the database of the TraumaRegister DGU between 2015 and 2022 was studied. In a stepwise approach, the occurrence of a TIC, the correlations between Hb\/BE levels and SCT, as well as ROTEM were calculated respectively. Then we aimed to detect relations between different Hb\/BE levels and the occurrence of TIC, using standard clotting studies and\/or ROTEM respectively.<\/jats:p><jats:p>\n          Results\u2003TIC occurred in 17.2% of the 68,996 primarily admitted adult patients with Injury Severity Score \u22659. A high correlation was found between Hb\/BE and SCT. With a decrease in Hb and BE, the frequency of TIC increased and at an admission Hb &lt;8\u2009g\/dL and BE &lt;\u2009\u22126\u2009mmol\/L, &gt;60% of patients presented with TIC. Clinical conditions associated with TIC were Glasgow Coma Scale \u22648, blood pressure \u226490\u2009mmHg on the scene or at hospital admission, prehospital volume &gt;1,000\u2009mL, serious injuries to the head and\/or the thorax and\/or the abdomen and\/or the extremities.<\/jats:p><jats:p>\n          Conclusion\u2003Almost one-sixth of patients present with a TIC at hospital admission. Blood gas analysis samples showed relevant correlations between Hb\/BE levels and SCT. The combined closer inspection of Hb\/BE and the clinical presentation of the patient is able to predict TIC in the majority of patients.<\/jats:p>","DOI":"10.1055\/a-2445-7163","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:40:16Z","timestamp":1737420016000},"source":"Crossref","is-referenced-by-count":1,"title":["Does a Simple Blood Gas Analysis and the Clinical Impression Predict Trauma-Induced Coagulopathy?"],"prefix":"10.1055","author":[{"given":"Peter","family":"Hilbert-Carius","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Bergmannstrost BG-Klinikum Halle, Saxonia-Anhalt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Lefering","sequence":"additional","affiliation":[{"name":"IFOM, Witten\/Herdecke University, K\u00f6ln, Nordrhein-Westfalen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Wrigge","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Bergmannstrost BG-Klinikum Halle, Saxonia-Anhalt, Germany"},{"name":"Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther O.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Jena University Hospital, Jena, Thueringen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Bergmannstrost BG-Klinikum Halle, Saxonia-Anhalt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e8","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Husum Hospital, Husum, Schleswig-Holstein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1186\/cc11432","article-title":"Predicting on-going hemorrhage and transfusion requirement after severe trauma: a validation of six scoring systems and algorithms on the TraumaRegister DGU","volume":"16","author":"T Brockamp","year":"2012","journal-title":"Crit Care"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/01.sla.0000256862.79374.31","article-title":"Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C 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