{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:53:14Z","timestamp":1771296794257,"version":"3.50.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac troponin-I is a known biomarker of myocardial injury in adults and children but its diagnostic utility is unclear in newborns.<\/jats:p><jats:p>This study aimed to establish normative data for troponin-I in stable newborns and assess any variation due to maternal diabetes status, mode of delivery, and Apgar scores.<\/jats:p><jats:p>Prospective, observational study of stable newborn \u226535 weeks gestation admitted to a well-baby nursery at a single institution. Infants with respiratory distress, congenital infections, malformations, or syndromes were excluded. Troponin-I values were obtained by a validated point-of-care capillary blood sample at 24\u2009hours of age.<\/jats:p><jats:p>A total of 132 patients were included for analysis. Thirteen infants were born to mothers with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy and analyzed as a subgroup, with the remaining 119 infants comprising the base cohort to establish baseline normative troponin-I levels in stable newborn infants. The mean (standard deviation) troponin-I level of infants in the base cohort group was 0.019\u2009\u00b1\u20090.018\u2009ng\/mL and in infants born with maternal SARS-CoV-2 infection during pregnancy troponin-I level was 0.081\u2009\u00b1\u20090.1\u2009ng\/mL (p\u2009&lt;\u20090.001). In infants of the base cohort, there was no significant difference in troponin-I levels between diabetic versus nondiabetic mothers, vaginal birth versus cesarean section, and 5-minute Apgar score of &lt;7 versus \u22657.<\/jats:p><jats:p>Cardiac troponin-I level in healthy term newborns was 0.019\u2009\u00b1\u20090.018\u2009ng\/mL, which conforms to healthy children and adult lab values. There was no statistically significant difference in troponin-I levels in infants of maternal diabetes or normal glucose status, mode of delivery, cesarean versus vaginal, or 5-minute Apgar score of &lt;7 or \u22657. Troponin-I levels in asymptomatic neonates born to mothers with a history of SARS-CoV-2 during pregnancy demonstrated an elevation when compared to the baseline group of infants.<\/jats:p>","DOI":"10.1055\/a-2448-0330","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T03:33:37Z","timestamp":1732592017000},"page":"997-1002","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Troponin-I Level at 24\u2009hours of Age in Stable Newborn Infants Born at \u226535 Weeks of Gestation"],"prefix":"10.1055","volume":"42","author":[{"given":"David C.","family":"Rosario","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Pezzano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesa","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Cerone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-4786","authenticated-orcid":false,"given":"Upender K.","family":"Munshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Albany Medical College, Albany, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1007\/s00246-019-02198-w","article-title":"What is the significance of elevated troponin I in children and adolescents? 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