{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:17:57Z","timestamp":1745554677855,"version":"3.30.1"},"reference-count":136,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Acute-on-chronic liver failure (ACLF) is defined as a clinical syndrome that develops in patients with chronic liver disease characterized by the presence of organ failure and high short-term mortality, although there is still no worldwide consensus on diagnostic criteria. Management of ACLF is mainly based on treatment of \u201cprecipitating factors\u201d (the most common are infections, alcohol-associated hepatitis, hepatitis B flare, and bleeding) and support of organ failure, which often requires admission to the intensive care unit. Liver transplantation should be considered in patients with ACLF grades 2 to 3 as a potentially life-saving treatment. When a transplant is not indicated, palliative care should be considered after 3 to 7 days of full organ support in patients with at least four organ failures or a CLIF-C ACLF score of &gt;70. This review summarizes the current knowledge on the management of organ failure in patients with ACLF, focusing on recent advances.<\/jats:p>","DOI":"10.1055\/a-2448-0664","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T22:51:57Z","timestamp":1729723917000},"page":"492-509","source":"Crossref","is-referenced-by-count":1,"title":["Managing Multiorgan Failure in Acute on Chronic Liver Failure"],"prefix":"10.1055","volume":"44","author":[{"given":"Enrico","family":"Pompili","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"},{"name":"Unit of Semeiotics, Liver and Alcohol-Related Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Iannone","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, 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