{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T07:46:32Z","timestamp":1775461592015,"version":"3.50.1"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2002 We aimed to examine both the expression levels of high mobility\n                    group box 1 (HMGB1) and vascular cell adhesion molecule-1 (VCAM-1) proteins in\n                    the placentas of pregnant women with gestational diabetes mellitus (GDM) and\n                    control groups by immunohistochemical (IHC) method.<\/jats:p><jats:p>\n          Material and methods\u2002 An experimental case-control study was conducted,\n                    including 40 pregnant women complicated with GDM and 40 healthy pregnant women.\n                    Placental tissues obtained following cesarean delivery were subjected to routine\n                    tissue monitoring. The placental sections were stained with VCAM-1 and HMGB1\n                    immunostains and subjected to IHC examination under a light microscope. H-score\n                    (HS) was used to evaluate the results of IHC staining by semi-quantitative\n                    analysis. Pathway analysis in Cytoscape software identified GDM-associated\n                    proteins within HMGB1 and VCAM-1 interaction networks, followed by GO analysis\n                    to explore associated biological processes.<\/jats:p><jats:p>\n          Results\u2002 Placental HGMB1 expression was significantly increased in the GDM\n                    group compared to the control group (p&lt;0.001). However, placental VCAM-1\n                    expression was found to be statistically similar in GDM and control groups\n                    (p=0.584). The shared 19 proteins were identified between HMGB1 and GDM, and 13\n                    between VCAM-1 and GDM, with notable GO biological process terms such as immune\n                    system activation for HMGB1 and interleukin-6 regulation for VCAM-1 associated\n                    with GDM.<\/jats:p><jats:p>\n          Conclusion\u2002 We consider that GDM-related inflammation and oxidative stress\n                    may contribute to tissue damage and inflammation by increasing placental HMGB1\n                    expression. The blockade of HMGB1 and its receptors might represent a promising\n                    therapeutic approach to control inflammation in GDM. Understanding the distinct\n                    roles of HMGB1 and VCAM-1 may provide valuable insights for the development of\n                    targeted therapies aimed at mitigating the inflammatory processes associated\n                    with GDM and improving maternal and fetal outcomes.<\/jats:p>","DOI":"10.1055\/a-2451-2223","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:07:53Z","timestamp":1731456473000},"page":"90-98","source":"Crossref","is-referenced-by-count":9,"title":["The Immunohistochemical and Bioinformatics Analysis of the Placental\n                    Expressions of Vascular Cell Adhesion Protein 1 (VCAM-1) and High Mobility Group\n                    Box 1 (HMGB1) Proteins in Gestational Diabetic Mothers"],"prefix":"10.1055","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-3008","authenticated-orcid":false,"given":"S\u00fcleyman Cemil","family":"O\u011flak","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Diyarbakir Gazi Yasargil\n                    Training and Research Hospital, Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-9146","authenticated-orcid":false,"given":"F\u0131rat","family":"A\u015f\u0131r","sequence":"additional","affiliation":[{"name":"Histology and Embryology, Dicle University, Diyarbakir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8340","authenticated-orcid":false,"given":"Emine Zeynep","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bah\u00e7elievler Memorial Hospital, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-6806","authenticated-orcid":false,"given":"G\u00f6khan","family":"Bolluk","sequence":"additional","affiliation":[{"name":"Perinatology, TC Sa\u011fl\u0131k Bakanl\u0131\u011f Ba\u015fak\u015fehir \u00c7am ve\n                    Sakura \u015eehir Hastanesi, Basaksehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-4022","authenticated-orcid":false,"given":"Tu\u011fcan","family":"Korak","sequence":"additional","affiliation":[{"name":"Medical Biology, Kocaeli University, Kocaeli,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4215-1371","authenticated-orcid":false,"given":"Elif","family":"A\u011fa\u00e7ayak","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Dicle University, Diyarbakir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2337\/dc22-S002","article-title":"2. 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of the placenta","volume":"22","author":"A Olmos-Ortiz","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.2147\/IJGM.S408856","article-title":"Low-grade inflammation in gestational diabetes mellitus and its correlation with\n                    maternal insulin resistance and fetal growth indices","volume":"16","author":"K Xuan Nguyen","year":"2023","journal-title":"Int J Gen Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2015.04.006","article-title":"Inflammation in maternal obesity and gestational diabetes mellitus","volume":"36","author":"P Pantham","year":"2015","journal-title":"Placenta"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1615\/CritRevEukaryotGeneExpr.2017019712","article-title":"Role of interleukin-6 in development of insulin resistance and type 2 diabetes\n                    mellitus","volume":"27","author":"K Rehman","year":"2017","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5468\/ogs.20020","article-title":"Role of interleukin-6 (IL-6) in predicting gestational diabetes mellitus","volume":"63","author":"A Amirian","year":"2020","journal-title":"Obstet Gynecol Sci"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2451-2223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T23:31:20Z","timestamp":1743723080000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2451-2223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":51,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2025,4,3]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2451-2223","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]}}}