{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:05:15Z","timestamp":1784156715233,"version":"3.55.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Congenital heart defects (CHD) being the most common congenital\nmalformation, significantly impact mortality and morbidity in children and\nadults. Early detection greatly improves treatment and prognosis. Routine pulse\noximetry screening and fetal echocardiography in Germany have advanced early CHD\ndiagnosis. However, a diagnostic gap persists, leaving some CHD cases\nundetected, worsening prognosis. This study aimed to evaluate echocardiographic\nscreening in newborns at a German university hospital as well as to record\nnumerous potential risk factors in a database.<\/jats:p>\n                  <jats:p>Patients and Methods This monocentric, prospective cohort study included\nostensibly healthy newborns delivered between 03\/2015 and 04\/2016.\nEchocardiography was performed at an average age of 3.15 days, with follow-up by\na specialist within six weeks and by telephone interview in 2019.<\/jats:p>\n                  <jats:p>Results Of 1006 newborns, 518 (51.49%) underwent echocardiography. CHD\nwere diagnosed in 7.14% (37\/518) with the following frequencies: atrial septal\ndefect (ASD) (45.95%), ventricular septal defect (VSD) (35.14%), persistent\nductus arteriosus (PDA) (8.11%), coarctation of aorta (CoA) with ASD (2.70%),\nquadricuspid aortic valve with VSD (2.70%), VSD with PDA (2.70%), and\nsignificant tricuspid regurgitation (2.70%). Follow-up in 2019 showed resolution\nof 31 CHD, while four patients continued regular cardiologist visits, with one\nrequiring urgent surgery for severe CoA.<\/jats:p>\n                  <jats:p>Conclusion This study demonstrates that echocardiographic screening in\nnewborns can detect previously undiagnosed CHD, including critical cases.<\/jats:p>","DOI":"10.1055\/a-2451-6770","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T19:01:16Z","timestamp":1733857276000},"page":"213-219","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Postnatal Echocardiographic Screening for Congenital\nHeart Defects \u2013 a Prospective Cohort Study at a German University\nHospital"],"prefix":"10.1055","volume":"238","author":[{"given":"Victoria Delphine","family":"Haberkern","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Medical\nCentre Mannheim Department of Pediatrics and Adolescent Medicine, Mannheim,\nGermany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Luisa","family":"Kilarski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Bonn,\nBonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schaible","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University Medical Centre Mannheim,\nMannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/s0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"J I Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1055\/s-0030-1254155","article-title":"Prevalence of 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Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/apa.12170","article-title":"Prevalence of congenital heart disease at live birth: an accurate assessment by\nechocardiographic screening","volume":"102","author":"Q M Zhao","year":"2013","journal-title":"Acta Paediatr"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1515\/jpm.2002.045","article-title":"Echocardiographic screening for congenital heart disease: a randomized\nstudy","volume":"30","author":"A Sands","year":"2002","journal-title":"J Perinat Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s12519-022-00560-2","article-title":"Using echocardiography in newborn screening for congenital heart disease may\nreduce missed diagnoses","volume":"18","author":"Y X Qiu","year":"2022","journal-title":"World J Pediatr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s13312-011-0021-1","article-title":"Clinical screening for Congenital heart disease at birth: a prospective study in\na community hospital in Kerala","volume":"48","author":"B Vaidyanathan","year":"2011","journal-title":"Indian Pediatr"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1159\/000176910","article-title":"Incidence of structural cardiac disorders in neonates: an evaluation by color\nDoppler echocardiography and the results of a 1-year follow-up","volume":"86","author":"A Ooshima","year":"1995","journal-title":"Cardiology"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s00112-016-0067-1","article-title":"L\u00e4ngsschnittstudie des aktuellen Wachstums 0\u2011 bis 6\u2011j\u00e4hriger deutscher Kinder:\nTeil 1","volume":"164","author":"V Hesse","year":"2016","journal-title":"Monatsschrift 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