{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T23:10:06Z","timestamp":1747696206843,"version":"3.40.5"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study is to investigate the lack of knowledge about the transplacental transport of antibodies in unvaccinated term and preterm infants and possible differences in antibody-mediated immunity in the fetus depending on maternal vaccination in their own infancy.<\/jats:p><jats:p>The study was conducted as a prospective cross-sectional study between 2017 and 2018 and included a total of 334 participants. The study included 194 pregnant women with a preterm birth (before 37 weeks) and 140 pregnant women with a term birth. Both umbilical cord blood and maternal blood were used to measure serum levels of anti-pertussis toxin (PT) immunoglobulin (Ig) G and anti-filamentous hemagglutinin (FHA) IgG.<\/jats:p><jats:p>The results showed that anti-FHA IgG antibody levels in the cord blood of women who had delivered at term were significantly higher than those of preterm infants (p\u2009=\u20090.002). The placental transfer rate of anti-PT IgG was higher in women who delivered prematurely, but this difference was not statistically significant (p\u2009=\u20090.128). However, transfer rates for anti-FHA were significantly higher in women who had delivered prematurely (p\u2009=\u20090.001). In addition, transmission rates for both antibodies were found to be significantly lower in women who delivered before 32 weeks gestation than in women who delivered at term (p\u2009=\u20090.006, p\u2009&lt;\u20090.001). Antibody transfer rates were found to be positively correlated with both gestational age and birth weight.<\/jats:p><jats:p>In summary, although placental antibody transfer rates increased with gestational age, transfer rates and antibody levels were low in pregnant women, particularly in women who had given birth before 32 weeks gestation.<\/jats:p>","DOI":"10.1055\/a-2457-2721","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:13:06Z","timestamp":1732925586000},"page":"1051-1058","source":"Crossref","is-referenced-by-count":0,"title":["Transplacental Transport Rates of Anti-Pertussis Toxin\u2013IgG and Anti-Filamentous Hemagglutinin\u2013IgG Antibodies in Newborns by Week of Birth"],"prefix":"10.1055","volume":"42","author":[{"given":"Oguzhan","family":"Inceli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Ankara Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemile","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Department of Communicable Diseases Research, Refik Saydam National Public Health Agency, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Ece","family":"\u0130nceli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Ankara Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan Onur","family":"Top\u00e7u","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Ankara Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujde Can","family":"Ibanoglu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Etlik Zubeyde Hanim Women's Health Training, and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaprak","family":"Engin-Ustun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Etlik Zubeyde Hanim Women's Health Training, and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-0897.1996.tb00172.x","article-title":"Evolution of maternofetal transport of immunoglobulins during human pregnancy","volume":"36","author":"A Malek","year":"1996","journal-title":"Am J Reprod Immunol"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/cid\/cix046","article-title":"Pertussis antibody transfer to preterm neonates after second- versus third-trimester maternal 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