{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:45:06Z","timestamp":1770882306126,"version":"3.50.1"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study explored the association between serum Hcy level and the all-cause\n                    mortality among osteoarthritis (OA) patients. This cohort study included\n                    patients diagnosed as OA from the National Health and Nutrition Examination\n                    Survey (NHANES) 1999\u20132006. Abbott Homocysteine assay, a fully automated\n                    fluorescence polarization immunoassay (FPIA) method, was used to measure the\n                    level of serum Hcy. Covariates included sociodemographic information,\n                    lifestyles, history of diseases and medications were extracted from the\n                    database. The weighted univariate, multivariate Cox proportional hazard models\n                    and restricted cubic splines (RCS) were utilized to explore the association\n                    between Hcy level and all-cause mortality in OA patients, with hazard ratios\n                    (HRs) and 95% confidence intervals (CIs). Subgroup analyses based on different\n                    age, gender, duration of OA, complications and C-reactive protein (CRP) were\n                    further assessed by this association. Totally 1384 OA patients were included in\n                    this study, of which 817 (59.03%) died by 31 December 2019. After adjusting all\n                    covariates, high Hcy level was associated with the high all-cause mortality\n                    among OA patients (HR=1.31, 95%CI: 1.02\u20131.67), especially in females (HR=1.43,\n                    95%CI: 1.07\u20131.91), aged &gt;60 years (HR=1.49, 95%CI: 1.14\u20131.94), duration of OA\n                    &gt;10 years (HR=1.40, 95%CI: 1.01\u20131.95), with the history of hypertension\n                    (HR=1.37, 95%CI: 1.03\u20131.80), without the history of diabetes (HR=1.36, 95%CI:\n                    1.01\u20131.82) or CRP &gt;0.29 mg\/l (HR=1.51, 95%CI: 1.04\u20132.19). High serum Hcy\n                    level was associated with high risk of all-cause mortality in OA patients. Our\n                    results suggest that serum Hcy is a promising biomarker for the prognosis of OA\n                    patients.<\/jats:p>","DOI":"10.1055\/a-2460-7718","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:23:08Z","timestamp":1733962988000},"page":"134-143","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Homocysteine and All-Cause Mortality Among\n                    Osteoarthritis Patients: A Cohort Study from the NHANES Database"],"prefix":"10.1055","volume":"57","author":[{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang\n                    Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang\n                    Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang\n                    Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang\n                    Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanchuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang\n                    Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5200-6646","authenticated-orcid":false,"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang\n                    Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","article-title":"The role of metabolism in the pathogenesis of osteoarthritis","volume":"13","author":"A Mobasheri","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"2019 American college of rheumatology\/arthritis foundation guideline for the\n                    management of osteoarthritis of the hand, 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2013\u20132015","volume":"66","author":"K E Barbour","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref45","first-page":"1330","article-title":"Knee effusions, popliteal cysts, and synovial thickening: association with knee\n                    pain in osteoarthritis","volume":"28","author":"C L Hill","year":"2001","journal-title":"J Rheumatol"},{"key":"ref46","first-page":"1","article-title":"Hospitalization for total knee replacement among inpatients aged 45 and over:\n                    United States, 2000\u20132010","volume":"210","author":"S N Williams","year":"2015","journal-title":"NCHS Data Brief"}],"container-title":["Hormone and Metabolic 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