{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:25:39Z","timestamp":1781544339700,"version":"3.54.5"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Elevated intracranial pressure can cause skull base defects and a spontaneous cerebrospinal fluid (CSF) leak. Venous sinus stenting (VSS) has emerged as a promising treatment option for patients with a CSF leak in the setting of idiopathic intracranial hypertension (IIH). There is a lack of literature on symptomatology and quality of life (QOL) after VSS for IIH patients with a CSF leak. This study explores the effects of VSS on symptoms and QOL in IIH patients with a CSF leak.<\/jats:p>\n                  <jats:p>This is a retrospective study on patients who have IIH complicated by a CSF leak and underwent VSS. A QOL questionnaire was developed from the migraine disability assessment test and the PROMIS-PI was given to patients included in this study.<\/jats:p>\n                  <jats:p>A total of 10 patients were included in this study. Nine patients underwent endoscopic closure of CSF prior to stent placement and one patient was treated with VSS only. There was no evidence of CSF leak recurrence in this population following VSS. Headaches improved in 5\/8, tinnitus in 5\/6, and visual disturbance in 4\/5 patients. Diamox was discontinued in seven out of eight patients after VSS. There was an improvement in headache-specific questions (p\u2009=\u20090.0140) and overall QOL (p\u2009=\u20090.0061) on the QOL questionnaire.<\/jats:p>\n                  <jats:p>This preliminary study demonstrates that VSS is effective in alleviating many symptoms in IIH patients with a CSF leak, especially headaches. Diamox may be able to be discontinued in many patients following VSS. No CSF leak recurrence was noted in this patient population.<\/jats:p>","DOI":"10.1055\/a-2461-5445","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T19:08:28Z","timestamp":1730920108000},"page":"661-666","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Venous Stenting on Symptoms and Quality of Life in Patients with Idiopathic Intracranial Hypertension and Spontaneous Cerebrospinal Fluid Leak"],"prefix":"10.1055","volume":"86","author":[{"given":"Shreya","family":"Mandloi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeba","family":"Nisar","sequence":"additional","affiliation":[{"name":"Jefferson Headache Center, Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-7398","authenticated-orcid":false,"given":"Samuel R.","family":"Shing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Benedict","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem E.","family":"Naamani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bray","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Reid","family":"Gooch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Toskala","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"},{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"},{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy R.","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"},{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiangkuo","family":"Yuan","sequence":"additional","affiliation":[{"name":"Jefferson Headache Center, Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurston G.","family":"Nyquist","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"},{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/ohn.414","article-title":"Transverse venous sinus stenosis in patients with nasal cerebrospinal fluid leak and idiopathic intracranial hypertension","volume":"169","author":"C Hurel","year":"2023","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/alr.22704","article-title":"International consensus statement: spontaneous cerebrospinal fluid rhinorrhea","volume":"11","author":"C Georgalas","year":"2021","journal-title":"Int Forum Allergy Rhinol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.wneu.2017.06.087","article-title":"Venous sinus stenting in the management of patients with intracranial hypertension manifesting with skull base cerebrospinal fluid leaks","volume":"106","author":"R R Iyer","year":"2017","journal-title":"World Neurosurg"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neurad.2021.07.002","article-title":"Venous sinus stenting after repair of skull base spontaneous cerebrospinal fluid leaks: a single-center retrospective cohort series with case-control analysis","volume":"49","author":"M A Labeyrie","year":"2022","journal-title":"J Neuroradiol"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.diii.2021.05.008","article-title":"Intracranial venous sinus stenting for the treatment of lateral sinus stenoses: an analysis of 200 patients","volume":"102","author":"M A Labeyrie","year":"2021","journal-title":"Diagn Interv Imaging"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1016\/j.wneu.2022.08.035","article-title":"Dural venous sinus stenting in idiopathic intracranial hypertension: a national database study of 541 patients","volume":"167","author":"A M Nia","year":"2022","journal-title":"World Neurosurg"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3171\/2021.5.JNS21894","article-title":"Transverse sinus stenting without surgical repair in idiopathic CSF rhinorrhea associated with transverse sinus stenoses: a pilot study","volume":"136","author":"S Lenck","year":"2021","journal-title":"J Neurosurg"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00701-023-05680-w","article-title":"Combined surgical repair and venous sinus stenting for patients with skull base encephaloceles secondary to dural venous sinus stenosis","volume":"165","author":"U Tosi","year":"2023","journal-title":"Acta Neurochir (Wien)"},{"issue":"18","key":"ref9","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1212\/WNL.0000000000003280","article-title":"Quality of life at 6 months in the idiopathic intracranial hypertension treatment trial","volume":"87","author":"B B Bruce","year":"2016","journal-title":"Neurology"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/neurintsurg-2020-016124","article-title":"Quality of life, need for retreatment, and the re-equilibration phenomenon after venous sinus stenting for idiopathic intracranial hypertension","volume":"13","author":"R M Garner","year":"2021","journal-title":"J Neurointerv Surg"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s10194-021-01339-y","article-title":"Minimal important change and responsiveness of the Migraine Disability Assessment Score (MIDAS) questionnaire","volume":"22","author":"G F Carvalho","year":"2021","journal-title":"J Headache Pain"},{"issue":"02","key":"ref12","first-page":"e4008","article-title":"Intracranial venous sinus stenting: a review of idiopathic intracranial hypertension and expanding indications","volume":"11","author":"L C Daggubati","year":"2019","journal-title":"Cureus"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1212\/WNL.45.12.2224","article-title":"Cerebral venography and manometry in idiopathic intracranial hypertension","volume":"45","author":"J O King","year":"1995","journal-title":"Neurology"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10143-023-02087-0","article-title":"Dural venous sinus stenting technique for idiopathic intracranial hypertension in patients with tortuous venous anatomy","volume":"46","author":"M Gorjian","year":"2023","journal-title":"Neurosurg Rev"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/neurintsurg-2018-014042","article-title":"Recommendations for the selection and treatment of patients with idiopathic intracranial hypertension for venous sinus stenting","volume":"10","author":"K M Fargen","year":"2018","journal-title":"J Neurointerv Surg"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/neurintsurg-2018-014172","article-title":"Venous sinus stenting for idiopathic intracranial hypertension: a systematic review and meta-analysis","volume":"11","author":"P Nicholson","year":"2019","journal-title":"J Neurointerv Surg"},{"key":"ref18","first-page":"jnis-2023-021336","article-title":"Redefining treatment expectations: exploring mid- and long-term outcomes of venous sinus stenting in idiopathic intracranial hypertension","author":"J P Midtlien","year":"2024","journal-title":"J Neurointerv Surg"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/1591019920956860","article-title":"Venous sinus stenting as a treatment approach in patients with idiopathic intracranial hypertension and encephaloceles","volume":"27","author":"G T Drocton","year":"2021","journal-title":"Interv Neuroradiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1186\/s10194-015-0521-9","article-title":"Headache determines quality of life in idiopathic intracranial hypertension","volume":"16","author":"Y Mulla","year":"2015","journal-title":"J Headache Pain"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10143-020-01288-1","article-title":"A systematic review of surgical treatments of idiopathic intracranial hypertension (IIH)","volume":"44","author":"A Kalyvas","year":"2021","journal-title":"Neurosurg Rev"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2461-5445.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T22:30:44Z","timestamp":1761345044000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2461-5445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":20,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2025,10,24]]},"published-print":{"date-parts":[[2025,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2461-5445","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"value":"2193-6331","type":"print"},{"value":"2193-634X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11,6]]},"published":{"date-parts":[[2024,11,6]]}}}