{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:36:20Z","timestamp":1785267380123,"version":"3.55.0"},"reference-count":94,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary bleeding disorders encompass a range of hemostasis defects that impair the blood coagulation process. Although these disorders affect both men and women, research and clinical management have historically been predominantly focused on male patients, particularly those with hemophilia. Consequently, the impact of these disorders on women has been undervalued and frequently overlooked. The intricate relationship between a woman's tendency to bleed and the various gynecological and obstetric processes gives rise to distinctive health challenges for women with hereditary bleeding disorders. Heavy menstrual bleeding (HMB), excessive bleeding during miscarriages, postpartum hemorrhage, and hemorrhagic ovarian cysts represent some of the most common complications. Despite the high prevalence and significant impact of these symptoms, many women experience delays in diagnosis and treatment, which in turn may result in iron-deficiency anemia, anxiety, influence on reproductive decisions, and a decreased quality of life. This review aims to summarize the distinctive characteristics of hereditary bleeding disorders in women, emphasizing the clinical challenges and hormonal management strategies for HMB.<\/jats:p>","DOI":"10.1055\/a-2462-6609","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:30:31Z","timestamp":1740007831000},"page":"070-079","source":"Crossref","is-referenced-by-count":3,"title":["Women and Hereditary Bleeding Disorders"],"prefix":"10.1055","volume":"45","author":[{"given":"Alessandra","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Children's Hospital Zurich, Eleonore Foundation, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehlia","family":"Moussaoui","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Obstetrics and Gynecology, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Casini","sequence":"additional","affiliation":[{"name":"Division of Angiology and Hemostasis, Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"issue":"13","key":"ref1","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1182\/blood-2014-08-532820","article-title":"Rare bleeding disorders: diagnosis and treatment","volume":"125","author":"R Palla","year":"2015","journal-title":"Blood"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"102460","DOI":"10.1016\/j.rpth.2024.102460","article-title":"Rare inherited coagulation disorders: no longer orphan and neglected","volume":"8","author":"S Mohsenian","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"issue":"S 03","key":"ref3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/hae.14986","article-title":"Rare bleeding disorders: Advances in management","volume":"30","author":"A Casini","year":"2024","journal-title":"Haemophilia"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1111\/j.1365-2516.2009.02072.x","article-title":"Gynaecological and obstetrical problems in women with different bleeding disorders","volume":"15","author":"S M Siboni","year":"2009","journal-title":"Haemophilia"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/hae.13722","article-title":"Barriers and challenges faced by women with congenital bleeding disorders in Europe: Results of a patient survey conducted by the European Haemophilia Consortium","volume":"25","author":"D Noone","year":"2019","journal-title":"Haemophilia"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"100726","DOI":"10.1016\/j.eclinm.2021.100726","article-title":"Major differences in clinical presentation, diagnosis and management of men and women with autosomal inherited bleeding disorders","volume":"32","author":"F Atiq","year":"2021","journal-title":"EClinicalMedicine"},{"issue":"S 03","key":"ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/hae.14094","article-title":"Women and girls with haemophilia: lessons learned","volume":"27","author":"R d'Oiron","year":"2021","journal-title":"Haemophilia"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2516.2005.01108.x","article-title":"More than menorrhagia: a review of the obstetric and gynaecological manifestations of bleeding disorders","volume":"11","author":"A H James","year":"2005","journal-title":"Haemophilia"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.thromres.2019.07.004","article-title":"Women with inherited bleeding disorders - challenges and strategies for improved care","volume":"196","author":"K O Presky","year":"2020","journal-title":"Thromb Res"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"e12652","DOI":"10.1002\/rth2.12652","article-title":"The lived experience of women with a bleeding disorder: a systematic review","volume":"6","author":"A Sanigorska","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/hae.15088","article-title":"Driving improvement of diagnosis and awareness of heavy menstrual bleeding in women among physicians","volume":"30","author":"R A Kadir","year":"2024","journal-title":"Haemophilia"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/hae.14643","article-title":"Gynaecological management of women with inherited bleeding disorders. 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