{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:18Z","timestamp":1756363218690,"version":"3.44.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate if retroverted (RV) uterus noted on nuchal translucency (NT) ultrasound is associated with second-trimester pregnancy loss and other adverse pregnancy outcomes.<\/jats:p><jats:p>This was a retrospective cohort study of patients with RV uterus documented on NT ultrasound at a single academic medical center from October 2019 to March 2023. Subjects were identified using a query for \u201cretroverted\u201d uterine position within an obstetric ultrasound imaging program. For each RV case, two anteverted (AV) subjects were selected for comparison. Patients with multiple gestation, Mullerian anomalies, or fetal aneuploidy were excluded. Maternal demographics, obstetric, and neonatal outcomes were obtained by chart review. Fisher's exact test and Mann\u2013Whitney test were used for categorical and continuous variables, respectively, with p-value &lt;0.05 denoting significance. Multivariable logistic regression was used to adjust for possible confounding variables.<\/jats:p><jats:p>Analysis included 249 patients\u201483 RV and 166 AV. RV patients were more likely to identify as Caucasian (71.1 vs. 49.4%, p\u2009=\u20090.001), have private insurance (80.7 vs. 59.4%, p\u2009=\u20090.001), lower body mass index (25.4\u2009\u00b1\u20095.1 vs 29.1\u2009\u00b1\u20097.2, p\u2009&lt;\u20090.001), and conceive by in vitro fertilization (IVF, 11 vs. 3%, p\u2009=\u20090.018). Most RV subjects (98%) had a resolution of retroversion by the second trimester. There was no difference in second-trimester pregnancy loss (0 vs. 1.2%, p\u2009=\u20090.55). After adjusting for race and IVF, RV subjects were four times more likely to have first-trimester vaginal bleeding (16.9 vs. 4.2%, odds ratio\u2009=\u20094.1, p\u2009=\u20090.0056). No other differences in adverse outcomes were observed.<\/jats:p><jats:p>Persistent RV uterus in the first trimester is associated with increased risk of first-trimester vaginal bleeding. However, rates of pregnancy loss were similar between groups, providing valuable information for patient counseling. Significantly more RV subjects conceived by IVF, highlighting the need for further study in this population.<\/jats:p>","DOI":"10.1055\/a-2466-1155","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T19:25:27Z","timestamp":1733340327000},"page":"1179-1185","source":"Crossref","is-referenced-by-count":0,"title":["Retroverted Uterus in the First Trimester and Associated Pregnancy Outcomes"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-8036","authenticated-orcid":false,"given":"Emily R.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Kantorowska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna M.","family":"Clough","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuella","family":"Kobara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Brite","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith L.","family":"Akerman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy L.","family":"Kinzler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Suhag","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Chavez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4648-0583","authenticated-orcid":false,"given":"Patricia","family":"Rekawek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, NYU Langone Hospital-Long Island, NYU Grossman Long Island School of Medicine, Mineola, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref1","volume-title":"Congenital genitourinary abnormalities","author":"G F Cunningham","year":"2022","edition":"26e 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