{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:25:09Z","timestamp":1784913909530,"version":"3.55.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Posterior reversible encephalopathy syndrome (PRES) is a\n                    clinical syndrome with numerous etiologies, mostly characterized by magnetic\n                    resonance imaging (MRI) abnormalities in the posterior cerebral white and gray\n                    matter and acute neurological symptoms.<\/jats:p>\n                  <jats:p>Aim To examine the predisposing factors, clinical results, and\n                    radiological features of PRES in children diagnosed with malignancy. Materials\n                    and<\/jats:p>\n                  <jats:p>Methods The study included 20 patients (7\u2009F\/13\u2009M) aged 4\u201316 years at the\n                    time of diagnosis who were diagnosed with malignancy and developed PRES during\n                    chemotherapy.<\/jats:p>\n                  <jats:p>Results All the patients were diagnosed as having PRES both clinically and\n                    radiographically during chemotherapy. The time from the initiation of the\n                    chemotherapy to the onset of PRES ranged from 7\u2013675 days. Hypertension was\n                    detected in nine patients, seizure was the most common presenting symptom \u2013 had\n                    involvement in the occipital and parietal lobes on MRI (n=14)\/followed by\n                    headache (n=8)\/altered consciousness (n=5)\/visual impairment (n=4).\n                    Hydrocephalus and tentorial herniation were observed in one patient. Most of the\n                    lesions on MRI resolved within 10\u201333 days and the EEG findings within 9 months.\n                    Clinical symptoms of PRES also disappeared completely the 5-year Press frequency\n                    was found to be 2.48%.<\/jats:p>\n                  <jats:p>Conclusion PRES may complicate the oncological treatment in children.\n                    Hypertension is a leading risk factor for PRES, while it should be kept in mind\n                    that the blood pressure may be normal in chemotherapy-induced PRES cases. PRES\n                    should be included in the differential diagnosis of all patients receiving\n                    chemotherapy and presenting with acute neurological symptoms.<\/jats:p>","DOI":"10.1055\/a-2468-3799","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T18:48:09Z","timestamp":1734720489000},"page":"141-152","source":"Crossref","is-referenced-by-count":2,"title":["Long-term evaluation of neurological outcomes in\n                    chemotherapy-associated posterior reversible encephalopathy (PRES) syndrome in\n                    children"],"prefix":"10.1055","volume":"237","author":[{"given":"G\u00f6k\u00e7e P\u0131nar","family":"Reis \u0130skendero\u011flu","sequence":"additional","affiliation":[{"name":"pediatric hematology and oncology, Karadeniz Technical University,\n                    Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-0060","authenticated-orcid":false,"given":"Beril","family":"Dilber","sequence":"additional","affiliation":[{"name":"pediatric neurology, Karadeniz Technical University Faculty of\n                    Medicine, Trabzon, Turkey"},{"name":"pediatric neurology, Karadeniz Technical University, Trabzon,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lker","family":"Ey\u00fcbo\u011flu","sequence":"additional","affiliation":[{"name":"radiology, Karadeniz Technical University Faculty of Medicine, TRABZON,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fenur","family":"Bahad\u0131r","sequence":"additional","affiliation":[{"name":"pediatric hematology and oncology, Karadeniz Technical University,\n                    Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Erduran","sequence":"additional","affiliation":[{"name":"pediatric hematology and oncology, Karadeniz Technical University,\n                    Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199602223340803","article-title":"A Reversibl Posterior Leukoencephalopathy Syndrome","volume":"334","author":"J Hinchey","year":"1996","journal-title":"N Engl Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4103\/0028-3886.55605","article-title":"Evaluation of nine children with reversible posterior encephalopathy\n                    syndrome","volume":"57","author":"F Incecik","year":"2009","journal-title":"Neurology India"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/practneurol-2011-000010","article-title":"The posterior reversible encephalopathy syndrome: what\u2019s certain, what\u2019s\n                    new?","volume":"11","author":"C Roth","year":"2011","journal-title":"Pract Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199602223340803","article-title":"A reversible posterior leukoencephalopathy syndrome","volume":"334","author":"J Hinchey","year":"1996","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1552-6569.2004.tb00223.x","article-title":"Neuroimaging in posterior reversible encephalopathy syndrome","volume":"14","author":"C Lamy","year":"2004","journal-title":"J Neuroimaging"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/pbc.21688","article-title":"Encephalopathy Syndrome in children with hemato-oncological disorders is not\n                    always posterior and reversible","volume":"51","author":"G Lucchini","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"ref7","first-page":"631","volume-title":"Annual Update in Intensive Care and Emergency Medicine 2011. 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