{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:44:46Z","timestamp":1791319486242,"version":"4.3.1"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Bei der systemischen Mastzellaktivierungserkrankung (MCAD) handelt es sich um eine epigenetisch und genetisch bedingte Krankheitsentit\u00e4t mit sehr ausgepr\u00e4gtem Krankheitsbild in vielf\u00e4ltigen klinischen Manifestationen in potenziell jedem Organ und Gewebe aufgrund unangemessener Freisetzung von Mastzellbotenstoffen zusammen mit der Anh\u00e4ufung von sowohl morphologisch normalen und mutierten Mastzellen. Die Pr\u00e4valenz der Erkrankung betr\u00e4gt in Deutschland 17%, sodass Gastroenterologen und Endoskopiker im klinischen Alltag h\u00e4ufig unwissentlich mit einer MCAD konfrontiert werden. Dar\u00fcber hinaus sind gastroenterologische Untersuchungen ein wesentlicher Bestandteil in der Diagnostik der MCAD. Daher ist es f\u00fcr jeden gastroenterologisch t\u00e4tigen Arzt unabdingbar, \u00fcber Grundkenntnisse dieser Erkrankung zu verf\u00fcgen und insbesondere \u00fcber deren Problematik auf dem gastroenterologischen Gebiet informiert zu sein. Diese \u00dcbersicht fasst den aktuellen Wissensstand zu Ursachen, Diagnostik und Therapie der hochkomplexen MCAD auf die gastroenterologischen Aspekte fokussiert zusammen.<\/jats:p>","DOI":"10.1055\/a-2468-5553","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T23:54:15Z","timestamp":1735948455000},"page":"155-168","source":"Crossref","is-referenced-by-count":4,"title":["Gastrointestinale Erscheinungsformen der systemischen Mastzellaktivierungserkrankung \u2013 Eine praxisorientierte Einf\u00fchrung in Klinik, Diagnostik und Therapie"],"prefix":"10.1055","volume":"63","author":[{"given":"Martin","family":"Raithel","sequence":"additional","affiliation":[{"name":"Waldkrankenhaus St. Marien, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Homann","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Gemeinschaftskrankenhaus Bonn, Bonn, 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