{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:26:18Z","timestamp":1782311178707,"version":"3.54.5"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Duodenal atresia is one of significant causes of neonatal intestinal obstruction. It often co-occurs with Down syndrome. This study is conducted to estimate the global prevalence of duodenal atresia in Down syndrome patients and to investigate associated factors.<\/jats:p><jats:p>\n          Methods\u2003Conducting a systematic review with meta-analysis of 18 eligible studies reporting duodenal atresia prevalence in pediatric Down syndrome patients. Study quality is assessed using the Newcastle-Ottawa Scale. The subgroup analysis on region, study quality, publication year, and design is addressed. Gender-specific prevalence rates are examined.<\/jats:p><jats:p>\n          Results\u2003The pooled prevalence of duodenal atresia in Down syndrome is 3.0%, with significant heterogeneity. The Middle East reports a higher prevalence of 6.0%, while Latin America, India, and Canada exhibit a lower prevalence of 1.0%. High-quality studies demonstrate 2% prevalence, while moderate-quality studies report 4.0%. Gender analysis indicates a similar incidence for females and males at 3.0%. Prevalence varies with study design: case-control studies report 4.0%, cross-sectional studies report 2.0%, and prospective cohort studies report 2.0%.<\/jats:p><jats:p>\n          Conclusions\u2003Duodenal atresia is common in Down syndrome patients, affecting 3.0% of the patients worldwide. Regional variations\u202fexist, necessitating further investigation. Gender does not significantly impact prevalence. This study highlights the need for region-specific research to enhance clinical decision-making for individuals with Down syndrome and duodenal atresia.<\/jats:p>","DOI":"10.1055\/a-2471-6435","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:26:34Z","timestamp":1733963194000},"page":"208-218","source":"Crossref","is-referenced-by-count":5,"title":["Global Prevalence of Duodenal Atresia in Trisomy 21: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8606-479X","authenticated-orcid":false,"given":"Dana Khaldun","family":"Atiyat","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina A.","family":"Al-Nusair","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrhman","family":"Alhajahjeh","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yousef","family":"Al-Awadi","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Aborajooh","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anesthesia, School of Medicine, Mu'tah University, Mu'tah, Karak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"F353","DOI":"10.1136\/fetalneonatal-2011-300631","article-title":"Epidemiology of small intestinal atresia in Europe: a register-based study","volume":"97","author":"K E Best","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00383-009-2406-y","article-title":"Duodenal atresia: associated anomalies, prenatal diagnosis and outcome","volume":"25","author":"M S Choudhry","year":"2009","journal-title":"Pediatr Surg Int"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jpedsurg.2009.01.025","article-title":"Laparoscopic duodenoduodenostomy in the neonate","volume":"44","author":"S Kay","year":"2009","journal-title":"J Pediatr Surg"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00439-009-0696-8","article-title":"Molecular genetic analysis of Down syndrome","volume":"126","author":"D Patterson","year":"2009","journal-title":"Hum Genet"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpeds.2007.09.045","article-title":"Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: a national study","volume":"152","author":"M E Weijerman","year":"2008","journal-title":"J Pediatr"},{"key":"ref6","first-page":"145","article-title":"Sex ratio of children with trisomy 21 or Down syndrome","volume":"51","author":"R S Verma","year":"1987","journal-title":"Cytobios"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/ajmg.a.61258","article-title":"Gastrointestinal disorders in Down syndrome","volume":"179","author":"B EBV Bermudez","year":"2019","journal-title":"Am J Med Genet A"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00004836-198604000-00002","article-title":"Down's syndrome and the gastrointestinal tract","volume":"8","author":"P J Buchin","year":"1986","journal-title":"J Clin Gastroenterol"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"15","key":"ref10","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. 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