{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T22:28:53Z","timestamp":1764282533101,"version":"3.46.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die prim\u00e4re Erythrozytose, auch Polyzyth\u00e4mia vera gennant, ist eine\n                    myeloproliferative Erkrankung, bei der es zu einer starken Vermehrung der\n                    Erythrozyten und damit zu einem starken H\u00e4matokritanstieg sowie einer Erh\u00f6hung\n                    der Gesamterythrozytenzahl kommt. Hierdurch steigt das Thromboserisiko und die\n                    Patienten zeigen eine erh\u00f6hte Blutungsneigung. H\u00e4ufige Symptome sind Schw\u00e4che\n                    und ZNS-St\u00f6rungen. Klinisch auff\u00e4llig sind vor allem dunkelrote Schleimh\u00e4ute.\n                    Bei der Diagnosestellung einer prim\u00e4ren Erythrozytose handelt es sich um ein\n                    Ausschlussverfahren, die die Bestimmung des Erythropoetin-Spiegels und die\n                    Aufarbeitung von Ursachen von sekund\u00e4ren Erythrozytosen umfasst (z.\u2009B.\n                    hypoxische Erkrankungen, Tumoren, Nierenerkrankungen). Die Therapie erfolgt\n                    durch anf\u00e4ngliche Aderl\u00e4sse, gegebenenfalls kombiniert mit einer Chemotherapie\n                    mit Hydroxyurea. Patienten k\u00f6nnen mit dieser Therapie mitunter Jahre \u00fcberleben.\n                    Im hier dargestellten Fall einer 6 Monate alten\n                    Berner-Sennen-Labrador-Mischlingsh\u00fcndin, welche mit Schw\u00e4che und dunkelroten\n                    Schleimh\u00e4uten vorgestellt wurde, konnte eine prim\u00e4re Erythrozytose\n                    diagnostiziert werden. Die H\u00fcndin zeigte jedoch kein Ansprechen auf die\n                    Chemotherapie. Zus\u00e4tzlich traten Fieber, Diarrh\u00f6 und Anorexie unter der Therapie\n                    auf. Die Symptome waren nach Absetzen des Hydroxyureas vollst\u00e4ndig reversibel.\n                    Die Aderl\u00e4sse mussten sehr frequent (im Abstand von 2 bis 3 Wochen) vorgenommen\n                    werden, da der H\u00e4matokritanstieg im Therapieverlauf unver\u00e4ndert rapide war. Der\n                    Fall zeigt, dass bei Hunden auch bei ausschlie\u00dflicher Therapie mit Aderl\u00e4ssen\n                    eine vollst\u00e4ndige Kontrolle der klinischen Symptome sowie eine \u00dcberlebenszeit\n                    von \u00fcber 30 Monaten erreicht werden kann.<\/jats:p>","DOI":"10.1055\/a-2471-6729","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:59:11Z","timestamp":1739905151000},"page":"47-54","source":"Crossref","is-referenced-by-count":0,"title":["Hydroxyurea-resistente, prim\u00e4re Erythrozytose bei einer juvenilen\n                    Mischlingsh\u00fcndin"],"prefix":"10.1055","volume":"53","author":[{"given":"Jessica","family":"Graf","sequence":"additional","affiliation":[{"name":"Tiermedizinisches Versorgungszentrum Dresdner Heide,\n                    Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Buder","sequence":"additional","affiliation":[{"name":"Tiermedizinisches Versorgungszentrum Dresdner Heide,\n                    Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00277-015-2357-4","article-title":"Current and future treatment options for polycythemia vera","volume":"94","author":"M Griesshammer","year":"2015","journal-title":"Ann Hematol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.7326\/0003-4819-95-1-71","article-title":"Polycythemia: mechanisms and management","volume":"95","author":"D W Golde","year":"1981","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1055\/s-2000-7728","article-title":"Polyzyth\u00e4mia vera. 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Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2471-6729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T22:25:46Z","timestamp":1764282346000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2471-6729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2025,2,18]]},"published-print":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2471-6729","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2025,2]]}}}