{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:23:57Z","timestamp":1770150237083,"version":"3.49.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background and study aims Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has recently emerged as a potential treatment option for malignant gastric outlet obstruction (mGOO), with a relatively long duration of patency and low rate of reintervention. Its intrinsic risk for serious adverse events and high procedure cost mandates careful patient selection beyond the common safety profiles. This study aimed to assess for predictors of early post-EUS-GE mortality.<\/jats:p><jats:p>\n            Patients and methods We conducted a retrospective analysis of all patients with unresectable mGOO who underwent EUS-GE. Predictive factors for postoperative 30-day mortality with crude and adjusted hazard ratios were examined using univariate and multivariate penalized likelihood Firth logistic regression analyses.<\/jats:p><jats:p>\n            Results Technical and clinical success was achieved in 96.7% and 93.1% of the patients, respectively. The 30-day mortality rate after the procedure was 11.7%, and no procedure complications were observed. The 30-day mortality group had a significantly low rate of initial clinical success (66.7% vs. 96.2%, P = 0.007). Univariate analysis identified significantly higher postoperative 30-day mortality in patients with poor baseline ECOG performance status scale (\u2265 2) and ascites. Presence of grade 2 ascites was confirmed as an independent predictive factor in the multivariate analysis (adjusted hazard ratio 52.41, 95% confidence interval 1.55 to 1775.64, P = 0.024).<\/jats:p><jats:p>\n            Conclusions EUS-GE should be carefully considered for patients with ascites which was an independent predictor for early mortality after procedure in mGOO, especially those with grade 2 or higher level of ascites.<\/jats:p>","DOI":"10.1055\/a-2474-9802","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T23:59:57Z","timestamp":1731974397000},"source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Predictive factors for early mortality after EUS-guided gastroenterostomy in malignant gastric outlet obstruction"],"prefix":"10.1055","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-7205","authenticated-orcid":false,"given":"Hyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-4339","authenticated-orcid":false,"given":"Kenneth Hyunsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulysses","family":"Rosas","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Othman","family":"El Helou","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-5101","authenticated-orcid":false,"given":"Jae Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea (the Republic of)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Bancila","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-7823","authenticated-orcid":false,"given":"Laith H","family":"Jamil","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, William Beaumont Hospital - Royal Oak, Royal Oak, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quin","family":"Liu","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabindra R.","family":"Watson","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Gaddam","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon K","family":"Lo","sequence":"additional","affiliation":[{"name":"Karsh Division of Digestive Diseases and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.giec.2011.04.002","article-title":"Enteral stents for malignant gastric outlet obstruction","volume":"21","author":"B Brimhall","year":"2011","journal-title":"Gastrointest Endosc Clin N 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