{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:56:32Z","timestamp":1767930992159,"version":"3.49.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Numerous studies have been conducted regarding vertebral restoration, development of kyphotic deformity, and pain control following balloon kyphoplasty. However, there is no consensus regarding the ideal time to perform kyphoplasty. Herein, we aimed to compare the results of treatment of different vertebral levels following early or late kyphoplasty.<\/jats:p>\n                  <jats:p>Between 2017 and 2022, 283 patients with single-level osteoporotic vertebral fractures were retrospectively reviewed. Patients in whom visual analog scale (VAS) values were recorded, and osteoporosis tests performed were included in the study. Traumatic single-level fractures in patients with osteoporosis who were aged\u2009&gt;\u200960 years were included. Patients with a history of malignancy, previous spinal surgery, or neurological deficits were excluded. A total of 100 patients met the inclusion criteria. A total of 50 patients underwent kyphoplasty within 3 days of sustaining the fracture (Group 1), and 50 patients underwent kyphoplasty more than 3 days after sustaining the fracture (Group 2). Groups A, B, and C included fractures at the T7\u2013T11 levels, T12\u2013L1 levels (thoracolumbar junction), and L2\u2013L5 levels, respectively. These groups were compared among themselves. Bilateral balloon kyphoplasty was performed under sedation in the prone position. Preoperative and postoperative VAS scores, anterior vertebral heights, and kyphotic angles (KAs) were measured and recorded. The vertebral segments that underwent early and late kyphoplasty were also compared among themselves.<\/jats:p>\n                  <jats:p>In all the patients who underwent early or late kyphoplasty, there was a significant decrease in the KA and a significant increase in vertebral heights during the early postoperative period (p\u2009&lt;\u20090.001). There was no significant change in the vertebral heights and KA between the early and late postoperative periods (p\u2009=\u20090.780). Early kyphoplasty demonstrated better pain control with a greater improvement in VAS score (p\u2009&lt;\u20090.001) than late kyphoplasty.<\/jats:p>\n                  <jats:p>Kyphoplasty plays an important role in reducing pain and ensuring early mobilization in older patients. In our study, the improvements in both symptoms and radiological features are concrete evidence in favor of performing early kyphoplasty.<\/jats:p>","DOI":"10.1055\/a-2479-5392","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T21:19:37Z","timestamp":1732223977000},"page":"032-038","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Kyphoplasty on Pain Control and Vertebral Restoration"],"prefix":"10.1055","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-6504","authenticated-orcid":false,"given":"Mustafa C.","family":"Kilinc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hitit University, Erol Olcak Education and Research Hospital, Corum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-0480","authenticated-orcid":false,"given":"Baran C.","family":"Alpergin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-1766","authenticated-orcid":false,"given":"Omer M.","family":"Ozpiskin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-9582","authenticated-orcid":false,"given":"Eray S.","family":"Aktan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-719X","authenticated-orcid":false,"given":"Ihsan","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.clineuro.2019.03.029","article-title":"Early versus late percutaneous kyphoplasty for treating osteoporotic vertebral compression fracture: a retrospective study","volume":"180","author":"X Zhou","year":"2019","journal-title":"Clin Neurol Neurosurg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0140-6736(16)31341-1","article-title":"Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"388","author":"W Clark","year":"2016","journal-title":"Lancet"},{"issue":"15","key":"ref3","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/BRS.0000000000000992","article-title":"Morbidity and mortality after vertebral fractures: comparison of vertebral augmentation and nonoperative management in the Medicare population","volume":"40","author":"A A Edidin","year":"2015","journal-title":"Spine"},{"issue":"19","key":"ref4","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2106\/JBJS.K.01649","article-title":"Impact of nonoperative treatment, vertebroplasty, and kyphoplasty on survival and morbidity after vertebral compression fracture in the Medicare population","volume":"95","author":"A T Chen","year":"2013","journal-title":"J Bone Joint Surg Am"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.14245\/ns.2346776.388","article-title":"Therapeutic prediction of osteoporotic vertebral compression fracture using the AO Spine-DGOU osteoporotic fracture classification and classification-based score: a single-center retrospective observational study","volume":"20","author":"K Mitani","year":"2023","journal-title":"Neurospine"},{"issue":"06","key":"ref6","first-page":"951","article-title":"Is balloon kyphoplasty effective for bone remodeling of AO-type A3-4 fractures at the thoracolumbar junction?","volume":"32","author":"I Uzunoglu","year":"2022","journal-title":"Turk Neurosurg"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jocd.2020.11.003","article-title":"The impact of bone mineral density on bone metabolism and the fracture healing process in elderly Chinese patients with osteoporotic vertebral compression fractures","volume":"24","author":"H Qi","year":"2021","journal-title":"J Clin Densitom"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.biomaterials.2016.10.004","article-title":"Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration","volume":"111","author":"D M Vasconcelos","year":"2016","journal-title":"Biomaterials"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","article-title":"Inflammation, fracture and bone repair","volume":"86","author":"F Loi","year":"2016","journal-title":"Bone"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.injury.2011.03.031","article-title":"The biology of fracture healing","volume":"42","author":"R Marsell","year":"2011","journal-title":"Injury"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jos.2017.09.019","article-title":"Differences in short-term clinical and radiological outcomes depending on timing of balloon kyphoplasty for painful osteoporotic vertebral fracture","volume":"23","author":"S Takahashi","year":"2018","journal-title":"J Orthop Sci"},{"issue":"03","key":"ref12","first-page":"396","article-title":"Does timing matter in performing kyphoplasty? Acute versus chronic compression fractures","volume":"75","author":"S Erkan","year":"2009","journal-title":"Acta Orthop Belg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.clineuro.2018.07.019","article-title":"Early versus delayed kyphoplasty for thoracolumbar osteoporotic vertebral fractures: the effect of timing on clinical and radiographic outcomes and subsequent compression fractures","volume":"173","author":"A Minamide","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7500716","DOI":"10.1155\/2022\/7500716","article-title":"Influence of different surgical timing after percutaneous kyphoplasty for osteoporotic vertebral compression fractures: a retrospective study","volume":"2022","author":"H Liu","year":"2022","journal-title":"Int J Clin Pract"},{"key":"ref15","first-page":"1662","article-title":"Clinical observation of percutaneous kyphoplasty at different times in treatment of osteoporotic vertebral compression fracture","volume":"3","author":"S Yao","year":"2015","journal-title":"Orthop J China"},{"issue":"09","key":"ref16","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/jbmr.3170","article-title":"Pain, quality of life, and safety outcomes of kyphoplasty for vertebral compression fractures: report of a task force of the American Society for Bone and Mineral Research","volume":"32","author":"A J Rodriguez","year":"2017","journal-title":"J Bone Miner Res"},{"key":"ref17","first-page":"6962","article-title":"Treatment timing for kyphoplasty with bone cement injection in patients with thoracolumbar vertebral compression fractures","volume":"19","author":"K H Ding","year":"2015","journal-title":"Chin J Tissue Eng Res"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.spinee.2004.01.003","article-title":"Acute versus chronic vertebral compression fractures treated with kyphoplasty: early results","volume":"4","author":"D Crandall","year":"2004","journal-title":"Spine J"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.36076\/ppj.2023.26.231","article-title":"Timing of percutaneous balloon kyphoplasty for osteoporotic vertebral compression fractures","volume":"26","author":"D Liu","year":"2023","journal-title":"Pain Physician"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2479-5392.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:41:15Z","timestamp":1767915675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2479-5392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":19,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,8]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2479-5392","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11,21]]},"published":{"date-parts":[[2024,11,21]]}}}