{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:46:23Z","timestamp":1764701183311,"version":"3.43.0"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>2019 coronavirus disease (COVID-19) has attracted global attention primarily because of the severe acute respiratory symptoms associated with it. However, nearly one third of the patients also present with neurological symptoms. This report describes a case of a previously healthy woman with acute COVID-19 infection, who developed acute facial nerve palsy and rapid progression to coma due to otogenic brain abscess.<\/jats:p><jats:p>A 63-year-old woman with acute COVID-19 infection exhibited acute facial nerve paresis, high fever, and purulent secretion from her left ear within 48\u2009hours after COVID-19 onset. Cranial computed tomography scan confirmed acute mastoiditis, precipitating an urgent mastoidectomy. A postoperative contrast-enhanced magnetic resonance imaging on the same day revealed a subdural empyema, which prompted an urgent craniotomy and decompression. Intraoperative microbiological swabs confirmed a Streptococcus pyogenes infection; however, reverse transcription polymerase chain reaction was negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After immediate intravenous antibiotic treatment, extubation was achieved 4 days after operation, and the patient was discharged without neurological deficits 19 days after postoperatively.<\/jats:p><jats:p>This finding adds a layer of insight into the specific nature of the infection, suggesting a potential absence of SARS-CoV-2 involvement in otogenic subdural empyema. However, the impact of SARS-CoV-2 in otogenic brain abscess cannot be excluded to date and should be further prospectively investigated. The complete recovery of neurological status emphasizes the importance of prompt and interdisciplinary interventions in managing rare and severe complications associated with COVID-19.<\/jats:p>","DOI":"10.1055\/a-2479-5462","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T19:01:02Z","timestamp":1732129262000},"page":"494-501","source":"Crossref","is-referenced-by-count":1,"title":["Otogenic Brain Abscess and Concomitant Acute COVID-19 Infection: Case Report and Review of the Literature"],"prefix":"10.1055","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4447-6919","authenticated-orcid":false,"given":"Artem","family":"Rafaelian","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae-Yeon","family":"Won","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"},{"name":"Department of Neurosurgery, University Hospital of Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svorad","family":"Trnovec","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"},{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bedjan","family":"Behmanesh","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"},{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Barz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Busjahn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-8429","authenticated-orcid":false,"given":"Daniel A.","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Mlynski","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Freiman","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Gessler","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"},{"name":"Department of Neurosurgery, Rostock University Medical Center, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dubinski","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurochirurgie, Universit\u00e4t Rostock, Rostock, Mecklenburg-Vorpommern, Germany"},{"name":"Department of Neurosurgery, Universit\u00e4tsmedizin Rostock, Rostock, Mecklenburg-Vorpommern, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10096-020-03874-z","article-title":"The epidemiology and clinical information about COVID-19","volume":"39","author":"H Ge","year":"2020","journal-title":"Eur J Clin Microbiol Infect"},{"issue":"01","key":"ref2","first-page":"20","article-title":"COVID-19 pandemic: from origins to outcomes. 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