{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:42:26Z","timestamp":1784630546317,"version":"3.55.0"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Background Refractory corneal edema is the foremost reason for endothelial corneal transplantation (EK) in the world. Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) offer good clinical outcomes. However, human donor tissue is limited in availability and has a complex logistical chain. Many patients in need do not have access to EK. Success of the human donor tissue depends on its quality, the number of rebubbles, repeat keratoplasties, and patient-related risk factors. The use of an endothelial corneal keratoprosthesis could benefit patients with a high risk for graft failure and human graft rejection, and patients in underserved areas where tissue banking is unavailable.<\/jats:p><jats:p>\n               Patients and Methods Case cohort series of 10 eyes of 10 patients implanted with the EndoArt, with a follow-up of up to 4.5 years. Outcome measures are device adherence, central corneal thickness, visual acuity, and incidence of adverse events.<\/jats:p><jats:p>\n               Results In the first seven eyes, the EndoArt was implanted in eyes with low visual potential within the first-in-human (FIH) trial, and in the three remaining eyes, implantation was performed because of either guarded posterior or anterior segment prognosis or the patient\u02bcs wishes. In 9\/10 eyes, device adherence was obtained and maintained throughout the follow-up period. Mean corneal thickness decreased from 927\u2009+\u2009SD 241 microns to 621\u2009+\u2009SD 140 microns. In 6\/10 eyes, visual acuity improved from a mean preoperative value of logMAR 1.94\u2009+\u20090.63 to a mean postoperative value of logMAR 0.8\u2009+\u20090.64. No pathological thinning or corneal metabolic changes were seen. The surgical technique was developed during the follow-up period.<\/jats:p><jats:p>\n               Conclusion The EndoArt provided a stable decrease in central corneal thickness, improved vision in 60% of eyes, and had no device-related adverse events. The EndoArt is an additional treatment modality for special cases like repeat corneal graft failure in the population of the Western world, or as a primary procedure in underserved areas worldwide.<\/jats:p>","DOI":"10.1055\/a-2479-8606","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T18:42:36Z","timestamp":1736793756000},"page":"318-323","source":"Crossref","is-referenced-by-count":8,"title":["4.5-Year Follow-up with a Novel Corneal Endothelial Prosthesis"],"prefix":"10.1055","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-4235","authenticated-orcid":false,"given":"Ruth","family":"Lapid-Gortzak","sequence":"additional","affiliation":[{"name":"Ophthalmology, Amsterdam UMC, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanka","family":"van der Meulen","sequence":"additional","affiliation":[{"name":"Ophthalmology, Amsterdam UMC, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ajo.2016.07.024","article-title":"Changing Practice Patterns and Long-term Outcomes of Endothelial Versus Penetrating Keratoplasty: A Prospective Dutch Registry Study","volume":"170","author":"M M Dickman","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.ophtha.2015.07.003","article-title":"The First 100 Eyes of Standardized Descemet Stripping Automated Endothelial Keratoplasty versus Standardized Descemet Membrane Endothelial Keratoplasty","volume":"122","author":"E C Hamzaoglu","year":"2015","journal-title":"Ophthalmology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.ophtha.2018.03.050","article-title":"Five-Year Graft Survival of Descemet Membrane Endothelial Keratoplasty (EK) versus Descemet Stripping EK and the Effect of Donor Sex Matching","volume":"125","author":"D A Price","year":"2018","journal-title":"Ophthalmology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ajo.2020.04.005","article-title":"Descemet Membrane Endothelial Keratoplasty: Ten-Year Graft Survival and Clinical Outcomes","volume":"217","author":"I Vasiliauskait\u0117","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/archopht.1965.00970030637007","article-title":"A buried corneal implant serving as a barrier to fluid","volume":"73","author":"S I Brown","year":"1965","journal-title":"Arch Ophthalmol"},{"key":"ref6","first-page":"851","article-title":"Replacement of the endothelium with alloplastic material: a new technique in corneal surgery","volume":"71","author":"C H Dohlman","year":"1967","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0002-9394(68)91282-8","article-title":"Optical properties of buried corneal silicone prostheses","volume":"66","author":"D Miller","year":"1968","journal-title":"Am J Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003734","article-title":"A novel artificial replacement membrane for the treatment of corneal edema: a first in human trial","author":"O Daphna","year":"2024","journal-title":"Cornea"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1097\/ICO.0000000000002806","article-title":"Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema","volume":"40","author":"G U Auffarth","year":"2021","journal-title":"Cornea"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1010652521578","article-title":"Acute corneal decompensation after silicone oil removal","volume":"23","author":"G Gurelik","year":"1999","journal-title":"Int Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"108068","DOI":"10.1016\/j.exer.2020.108068","article-title":"12. Endothelial pump and barrier function","volume":"198","author":"S D Klyce","year":"2020","journal-title":"Exp Eye Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/ICO.0000000000003433","article-title":"Early Outcomes of an Artificial Endothelial Replacement Membrane Implantation After Failed Repeat Endothelial Keratoplasty","volume":"43","author":"L Fontana","year":"2024","journal-title":"Cornea"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global Survey of Corneal Transplantation and Eye Banking","volume":"134","author":"P Gain","year":"2016","journal-title":"JAMA Ophthalmol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2479-8606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T23:52:06Z","timestamp":1759362726000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2479-8606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":13,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,4,16]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2479-8606","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}