{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T23:44:03Z","timestamp":1765583043591,"version":"3.48.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ultra-high-frequency ultrasound (UHF-US) allows visualization of the epidermis, dermis, and subcutis and precise measurement of skin thickness. The aim of this study was to assess the performance and interobserver reliability of UHF-US for measuring skin thickness in patients with long-term systemic glucocorticoid (GC) therapy compared to patients without GC therapy or treated for a shorter period.<\/jats:p>\n                  <jats:p>156 patients with known or suspected inflammatory rheumatic diseases underwent US evaluation for skin thickness by 3 experts in 3 anatomical sites (hand, distal, and proximal forearm). 87 patients were classified as \u201cfrequent users\u201d who had received continuous oral GCs for at least one year or at least 3 years with various interruptions. 69 patients without any oral GC therapy in the past or treated for a shorter period were classified as \u201cnon-frequent users\u201d.<\/jats:p>\n                  <jats:p>UHF-US allowed a precise measurement of skin thickness. Skin thickness at all 3 anatomical sites was significantly decreased in \u201cfrequent users\u201d of GCs compared to \u201cnon-frequent users\u201d (distal and proximal forearm: p &lt; 0.001; hand: p &lt; 0.05). At all 3 anatomical sites, skin thickness was decreased in patients with clinically assessed parchment-like skin compared to patients without parchment-like skin (distal and proximal forearm: p &lt; 0.001; hand: p &lt; 0.05). Interobserver variability was excellent [hand intraclass correlation coefficient (ICC) = 0.99; proximal forearm ICC = 0.85; distal forearm ICC = 0.84].<\/jats:p>\n                  <jats:p>These data support the idea of UHF-US as an objective and reliable imaging tool for monitoring skin atrophy as adverse effects of GC therapy.<\/jats:p>","DOI":"10.1055\/a-2479-8829","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T19:18:16Z","timestamp":1738783096000},"page":"578-584","source":"Crossref","is-referenced-by-count":0,"title":["Performance of ultra-high-frequency ultrasound in the evaluation of skin atrophy in patients with long-term oral glucocorticoid therapy in a tertiary rheumatology center"],"prefix":"10.1055","volume":"46","author":[{"given":"Timo","family":"Turowski","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Asclepios Clinic Bad Abbach, Bad Abbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Fleck","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Asclepios Clinic Bad Abbach, Bad Abbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Ehrenstein","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Asclepios Clinic Bad Abbach, Bad Abbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Asclepios Clinic Bad Abbach, Bad Abbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Asclepios Clinic Bad Abbach, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/rheumatology\/key169","article-title":"\u201cThe 70th anniversary of glucocorticoids in rheumatic diseases: the second youth of an old friend\u201d","volume":"58","author":"Y Palmowski","year":"2019","journal-title":"Rheumatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/annrheumdis-2019-215672","article-title":"2018 update of the EULAR recommendations for the management of large vessel vasculitis","volume":"79","author":"B Hellmich","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1001\/jama.2020.10155","article-title":"Polymyalgia rheumatica and giant cell arteritis","volume":"324","author":"F 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