{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:40:57Z","timestamp":1784356857601,"version":"3.55.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"OMRON Healthcare Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is a well-known risk factor for atrial fibrillation (AF) and strokes, but studies assessing screening-detected AF in hypertensive populations and its relationship to the blood pressure (BP) are scarce.<\/jats:p><jats:p>We prospectively recruited hypertensive patients (aged \u226560 years) from all over Japan in a decentralized clinical trial. Participants were asked to measure their electrocardiogram (ECG) and BP at home for 3 months with a BP monitor equipped with ECG.<\/jats:p><jats:p>Between April 2022 and July 2023, 4,078 hypertensive patients from across the country participated in this study. The mean age was 66.3\u2009\u00b1\u20095.5 years, and the male proportion was 80.3%. After excluding those with no measurement data (n\u2009=\u2009258), AF detection was 5.8% (n\u2009=\u2009220\/3,820), and the time to AF detection was 3 to 109 days (median 28 days). The mean BP at baseline was 133\u2009\u00b1\u200914\/85\u2009\u00b1\u20099\u2009mmHg in the morning and 125\u2009\u00b1\u200914\/79\u2009\u00b1\u20099\u2009mmHg in the evening. AF detection did not significantly differ between the baseline BP categories (log rank test, p\u2009=\u20090.54), with hazard ratios (95% confidence interval) of 0.83 (0.57\u20131.19), 0.79 (0.55\u20131.14), and 0.99 (0.59\u20131.68) for systolic BP (SBP) 135 to 144 and\/or diastolic BP (DBP) 85 to 89, SBP 145 to 159 and\/or DBP 90 to 99, and SBP \u2265 160 and\/or DBP \u2265 100, respectively (SBP \u2264 134 and DBP \u2264 84 as a reference). The results did not change when taking into account the impact of the measurement rates and antihypertensive drugs on AF detection during the observation period.<\/jats:p><jats:p>Detection of undiagnosed AF was 5.8% in elderly hypertensives, with no significant differences between the baseline BP categories and no effect of the measurement rate or antihypertensive drugs.<\/jats:p>","DOI":"10.1055\/a-2484-0641","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T03:58:26Z","timestamp":1732593506000},"page":"545-552","source":"Crossref","is-referenced-by-count":3,"title":["Relationship Between Screening-Detected Atrial Fibrillation and Blood Pressure Levels in Elderly Hypertensive Patients: The OMRON Heart Study"],"prefix":"10.1055","volume":"125","clinical-trial-number":[{"clinical-trial-number":"umin000053140","registry":"10.18810\/umin-japan"}],"author":[{"given":"Keitaro","family":"Senoo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuko","family":"Nakata","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arito","family":"Yukawa","sequence":"additional","affiliation":[{"name":"Department of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobunari","family":"Tomura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Iwakoshi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Shimoo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoaki","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Cardiac Arrhythmia Research and Innovation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/01.HYP.0000052830.02773.E4","article-title":"Atrial fibrillation in hypertension: predictors and outcome","volume":"41","author":"P Verdecchia","year":"2003","journal-title":"Hypertension"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/jhh.2011.105","article-title":"Hypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implications","volume":"26","author":"Y F Lau","year":"2012","journal-title":"J Hum Hypertens"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/00015385.2021.1882111","article-title":"Risk of stroke and bleeding in relation to hypertension in anticoagulated patients with atrial fibrillation: a meta-analysis of randomised controlled trials","volume":"77","author":"R E Harskamp","year":"2022","journal-title":"Acta Cardiol"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00392-021-01941-9","article-title":"Mobile health solutions for atrial fibrillation detection and management: a systematic review","volume":"111","author":"A NL Hermans","year":"2022","journal-title":"Clin Res Cardiol"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1253\/circrep.CR-20-0032","article-title":"Diagnostic value of atrial fibrillation by built-in electrocardiogram technology in a blood pressure monitor","volume":"2","author":"K Senoo","year":"2020","journal-title":"Circ Rep"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"e0269506","DOI":"10.1371\/journal.pone.0269506","article-title":"Screening for untreated atrial fibrillation in the elderly population: a community-based study","volume":"17","author":"K Senoo","year":"2022","journal-title":"PLoS One"},{"key":"ref7","first-page":"101177","article-title":"The impact of home electrocardiograph measurement rate on the detection of atrial fibrillation recurrence after ablation: a prospective multicenter observational study","volume":"44","author":"K Senoo","year":"2023","journal-title":"Int J Cardiol Heart Vasc"},{"issue":"17","key":"ref8","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1161\/CIRCULATIONAHA.117.028981","article-title":"Sex differences and similarities in atrial fibrillation epidemiology, risk factors, and mortality in community cohorts: results from the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)","volume":"136","author":"C Magnussen","year":"2017","journal-title":"Circulation"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/ajh.2008.248","article-title":"Blood pressure control and risk of incident atrial 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Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"J A Joglar","year":"2024","journal-title":"Circulation"},{"issue":"17","key":"ref15","first-page":"e426","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"138","author":"P K Whelton","year":"2018","journal-title":"Circulation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejim.2023.08.019","article-title":"Renin-angiotensin-aldosterone system inhibitors and mortality risk in elderly patients with atrial fibrillation. 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