{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:06:22Z","timestamp":1788318382631,"version":"build-2803163510"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Clinical Research Project of Jiangsu Commission of Health","award":["K2023002"],"award-info":[{"award-number":["K2023002"]}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82173353"],"award-info":[{"award-number":["82173353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Top Talent Scientific Research Project of \u201cSix One Projects\u201d","award":["LGY2018028"],"award-info":[{"award-number":["LGY2018028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Portal vein system thrombosis (PVST) is a frequent and possibly fatal concurrent disorder following splenectomy. The optimal anticoagulant to prevent PVST following splenectomy remains unclear.<\/jats:p><jats:p>The purpose of this study was to compare the safety and efficacy of apixaban versus aspirin in preventing PVST after laparoscopic splenectomy (LS) for cirrhotic hypersplenism.<\/jats:p><jats:p>In this single-center randomized controlled trial, 80 patients with liver cirrhosis who received LS were randomly allocated to two treatment arms that were treated with apixaban or aspirin for 6 months. The primary effectiveness outcome was PVST formation after LS.<\/jats:p><jats:p>We excluded four patients who withdrew from the study. The dynamic incidence of PVST, main and intrahepatic branches of PVST, and splenic vein thrombosis in the 6 postoperative months were all significantly lower in the apixaban treatment arm compared to the aspirin treatment arm (all P &lt;0.001). Significantly lower incidences of PVST, main and intrahepatic branches of PVST, and splenic vein thrombosis in apixaban treatment arm started from postoperative day 7, month 1, and day 7 compared to the aspirin treatment arm respectively (all P &lt;0.05). Multiple logistic regression analysis revealed that apixaban was an independent protective factor for PVST at postoperative month 3, as compared with aspirin (relative risk, 0.057; 95% confidence interval, 0.013\u20130.248; P &lt;0.001).<\/jats:p><jats:p>Compared with aspirin, apixaban could earlier and more effectively prevent PVST following LS for cirrhotic hypersplenism. Apixaban can be chosen as a priority treatment option versus aspirin, contributing to a lower risk of PVST.<\/jats:p>","DOI":"10.1055\/a-2484-0747","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T18:53:17Z","timestamp":1734115997000},"page":"871-879","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Apixaban and Aspirin in Preventing Portal Vein Thrombosis after Laparoscopic Splenectomy for Cirrhotic Hypersplenism"],"prefix":"10.1055","volume":"125","author":[{"given":"Zhaobao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"The Yangzhou School of Clinical Medicine of Dalian Medical University, Dalian, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunqing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dousheng","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital, Yangzhou, China"},{"name":"Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/bjs.7002","article-title":"Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension","volume":"97","author":"N Kinjo","year":"2010","journal-title":"Br J 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Hepatol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/gut.49.5.720","article-title":"Extrahepatic portal vein thrombosis: aetiology and determinants of survival","volume":"49","author":"H L Janssen","year":"2001","journal-title":"Gut"},{"issue":"09","key":"ref6","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1097\/00007890-200005150-00023","article-title":"Portal vein thrombosis in adults undergoing liver transplantation: risk factors, screening, management, and outcome","volume":"69","author":"M A Yerdel","year":"2000","journal-title":"Transplantation"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0002-9610(02)01095-4","article-title":"Portal vein thrombosis after splenectomy","volume":"184","author":"E R Winslow","year":"2002","journal-title":"Am J Surg"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/hep.23259","article-title":"Acute 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