{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:09Z","timestamp":1792251189076,"version":"4.4.0"},"reference-count":66,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/100007793","name":"Stiftelsen Kristian Gerhard Jebsen","doi-asserted-by":"crossref","award":["SKGJ-MED-012"],"award-info":[{"award-number":["SKGJ-MED-012"]}],"id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL059367"],"award-info":[{"award-number":["R01HL059367"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL155209"],"award-info":[{"award-number":["R01HL155209"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to identify novel plasma proteins associated with first-lifetime venous thromboembolism (VTE) and molecular pathways involved in VTE pathogenesis.<\/jats:p><jats:p>A case\u2013cohort comprising incident VTE cases (n\u2009=\u2009294) and a randomly sampled age- and sex-weighted subcohort (n\u2009=\u20091,066) was derived from the Tr\u00f8ndelag Health Study (HUNT3, n\u2009=\u200950,800). Blood samples were collected and stored at cohort inclusion (2006\u20132008), and participants were followed up to 5 years. Proteome-wide analyses was performed using the 7k SomaScan\u00ae proteomics platform, and weighted Cox-regression models adjusted for age, sex, and sample batch were conducted, with the Bonferroni method applied to account for multiple testing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were applied on the top-ranked 200 proteins associated with VTE.<\/jats:p><jats:p>Out of 7,288 human proteins, 7 proteins were significantly associated with higher VTE risk with p-value &lt;6.9\u2009\u00d7\u200910\u22126 (hazard ratios per 1 standard deviation increase in protein levels ranging from 1.39 to 1.86). Except for coagulation factor VIII and tumor necrosis factor soluble receptor II, these proteins were novel associations and included collagen alpha-3(VI):BPTI\/Kunitz inhibitor, histo-blood group ABO system transferase, peroxidasin, human epididymis protein 4, and regulator of G protein signaling 3. KEGG analyses of the top-ranked 200 proteins revealed significant pathway enrichment of nine proteins in the complement (mainly lectin pathway) and coagulation (mainly intrinsic pathway) cascades.<\/jats:p><jats:p>Our proteome-wide analysis led to discovery of five novel protein candidates associated with 5-year risk of future VTE. KEGG analyses supported an interplay between the complement and coagulation pathways in the pathogenesis of VTE.<\/jats:p>","DOI":"10.1055\/a-2484-0836","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T03:58:26Z","timestamp":1732593506000},"page":"574-584","source":"Crossref","is-referenced-by-count":10,"title":["The Plasma Proteome and Risk of Future Venous Thromboembolism\u2014Results from the HUNT Study"],"prefix":"10.1055","volume":"125","author":[{"given":"Sigrid K.","family":"Br\u00e6kkan","sequence":"additional","affiliation":[{"name":"Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"Thrombosis Research group (TREC), Department of Clinical Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn L.","family":"Onsaker","sequence":"additional","affiliation":[{"name":"Thrombosis Research group (TREC), Department of Clinical Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese H.","family":"N\u00f8st","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Community Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian D.","family":"Hindberg","sequence":"additional","affiliation":[{"name":"Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania M.","family":"Morelli","sequence":"additional","affiliation":[{"name":"Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"Thrombosis Research group (TREC), Department of Clinical Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Guan","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jonasson","sequence":"additional","affiliation":[{"name":"HUNT Research Center, Norwegian University of Science and Technology, Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-2699","authenticated-orcid":false,"given":"Aaron R.","family":"Folsom","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"HUNT Research Center, Norwegian University of Science and Technology, Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Bjarne","family":"Hansen","sequence":"additional","affiliation":[{"name":"Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"Thrombosis Research group (TREC), Department of Clinical Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10654-021-00813-w","article-title":"Estimated lifetime risk of venous thromboembolism in men and women in a Danish nationwide cohort: impact of competing risk of death","volume":"37","author":"C AL Arnesen","year":"2022","journal-title":"Eur J 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