{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:46:11Z","timestamp":1759837571805,"version":"3.41.2"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"U.S. Department of Health and Human Services, National Institutes of Health","award":["HD 11725"],"award-info":[{"award-number":["HD 11725"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to test the hypothesis that the development or deterioration of nephropathy and retinopathy over time is not affected by pregnancy in women with pregestational type 1 diabetes mellitus (T1DM).<\/jats:p><jats:p>Prospective, observational study of nephropathy and retinopathy follow-up during pregnancy and in a subsequent period of 2 years in a group of pregnant women with T1DM (study group) that we compared with pair-matched non-pregnant women with T1DM (control group) who underwent similar intensive follow-up.<\/jats:p><jats:p>The rate of renal microvascular complications was similar at entry, 17.4% (4\/23) in the study group and 21.7% (5\/23) in the control group. At the last visit, both groups had nephropathy rates of 17.4% (4\/23) and paired p-value of 1.00. Similarly, the rate of retinal microvascular complications of any grade was similar in both groups and remained so at the last follow-up examination.<\/jats:p><jats:p>Pregnancy per se does not appear to increase the risk for the development of, or the acceleration of the progression of retinopathy and nephropathy during a follow-up of at least 2 years in relatively healthy T1DM patients. This information is important for counseling young women with T1DM who are considering becoming pregnant.<\/jats:p>","DOI":"10.1055\/a-2489-4588","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T23:46:36Z","timestamp":1735083996000},"page":"1304-1310","source":"Crossref","is-referenced-by-count":1,"title":["Is Pregnancy a Risk Factor for Progression of Diabetic Retinopathy and Nephropathy in Type 1 Diabetes? A Matched Cohort Study"],"prefix":"10.1055","volume":"42","author":[{"given":"Francis","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Research Institute, Leumit Health Services, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane C.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galit","family":"Sheffer-Mimouni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, and Research Institute, Leumit Health Services, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barak","family":"Rosenn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Health, Rutgers New Jersey Medical School, Jersey city Medical Center, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menachem","family":"Miodovnik","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Inova 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