{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T23:40:01Z","timestamp":1745624401794,"version":"3.40.4"},"reference-count":115,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Alcohol-associated liver disease (ALD), primarily caused by chronic excessive alcohol consumption, is a leading cause of chronic liver disease worldwide. ALD includes alcohol-associated steatotic liver, alcohol-associated hepatitis (AH), fibrosis, cirrhosis, and can even progress to hepatocellular carcinoma (HCC). Existing research indicates that the risk factors of ALD are quite numerous. In addition to drinking patterns, factors such as aldehyde dehydrogenase 2 (ALDH2) deficiency, smoking, medication administration, high-fat diet (HFD), hepatitis virus infection, and disruption of circadian rhythms can also increase susceptibility to ALD. However, there is limited understanding regarding the exacerbation of liver injury by alcohol plus additional risk factors. This review presents rodent models of EtOH\u2009+\u2009\u201cX,\u201d which simulate the synergistic effects of alcohol and additional risk factors in causing liver injury. These models offer a further exploration of the interactions between alcohol and additional risk factors, advancing the simulation of human ALD and providing a more reliable platform for studying disease mechanisms and exploring therapeutic interventions. We summarize the modeling methods, relevant indicators of liver injury, and focus on the targets of the synergistic effects as well as the associated mechanisms.<\/jats:p>","DOI":"10.1055\/a-2490-4278","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T23:54:01Z","timestamp":1735084441000},"page":"081-098","source":"Crossref","is-referenced-by-count":0,"title":["Alcohol Plus Additional Risk Factors: Rodent Model of Liver Injury"],"prefix":"10.1055","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3644-5043","authenticated-orcid":false,"given":"Qixiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, Anhui, P.R. China"},{"name":"Institute for Liver Diseases of Anhui Medical University, Hefei, Anhui, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3157-3550","authenticated-orcid":false,"given":"Dashuai","family":"Yang","sequence":"additional","affiliation":[{"name":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, Anhui, P.R. China"},{"name":"Institute for Liver Diseases of Anhui Medical University, Hefei, Anhui, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6490-002X","authenticated-orcid":false,"given":"Chixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Southern Medical University, Nanfang Hospital, Guangzhou, P.R. China"},{"name":"School of Laboratory and Biotechnology, Institute of Antibody Engineering, Southern Medical University, Guangzhou, Guangdong, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-0451","authenticated-orcid":false,"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, Anhui, P.R. China"},{"name":"Institute for Liver Diseases of Anhui Medical University, Hefei, Anhui, P.R. 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