{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:55:22Z","timestamp":1792173322978,"version":"4.4.0"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"DOI":"10.13039\/100015769","name":"Dexcom","doi-asserted-by":"crossref","award":["Study devices were provided by Dexcom Inc. No addi"],"award-info":[{"award-number":["Study devices were provided by Dexcom Inc. No addi"]}],"id":[{"id":"10.13039\/100015769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to evaluate the relationship between intrapartum continuous glucose monitoring (CGM) and neonatal hypoglycemia (NH) in individuals with diabetes.<\/jats:p><jats:p>a multicenter prospective study (November 2021\u2013December 2022) of laboring individuals with pregestational or gestational diabetes at \u226534 weeks. Cohorts had a blinded CGM placed from admission through delivery and were monitored with fingerstick (FS) according to usual care. The primary outcome was NH. Secondary neonatal outcomes included neonatal intensive care unit (NICU) length of stay, need for intravenous (IV) glucose therapy, hyperbilirubinemia, respiratory distress, or respiratory distress syndrome. Time in the target range (TIR; range 70\u2013110\u2009mg\/dL) and time above the target range (TAR; &gt;110\u2009mg\/dL) were expressed as a percentage of all CGM readings, and mean glucose was obtained. Youden index was used to choose the cut point for TAR and prediction of NH.<\/jats:p><jats:p>Of 9,479 deliveries during the study period, 202 (2.1%) met the inclusion criteria, and 112 (56%) participants were enrolled (n\u2009=\u20097 did not have available CGM data). Of the study participants, 45 (40%) had pregestational diabetes, and 67 (60%) had gestational diabetes. The mean glucose in labor using a CGM was 102.6\u2009mg\/dL (interquartile range [IQR]:89.9, 113.5\u2009mg\/dL), and the average percentage of TIR was 62.1% (IQR, 36.9, 85.6). CGM and FS were poor predictors of NH, with no differences in area under the curve (AUC) of mean glucose as a predictor (0.64, 95% CI: 0.48\u20130.23 vs. 0.53, 95% CI: 0.4\u20130.6, respectively). The best cut-off for the prediction of NH was a TAR of 61%, with 23% (n\u2009=\u200924) being above the threshold. The rate of NH for TAR &gt;61% versus \u226461% was 45.8 versus 25.9% (p\u2009=\u20090.06). Neonates born to individuals with TAR &gt;61% were more likely to require continuous positive airway pressure after delivery and had a higher cord c-peptide level.<\/jats:p><jats:p>In this prospective study of laboring individuals with diabetes, intrapartum CGM TAR was associated with a higher rate of NH.<\/jats:p>","DOI":"10.1055\/a-2494-2157","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:50:54Z","timestamp":1733187054000},"page":"1344-1353","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between Intrapartum Continuous Glucose Monitoring Values and Neonatal Hypoglycemia in Individuals with Diabetes"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-566X","authenticated-orcid":false,"given":"Michal","family":"Fishel Bartal","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Nazeer","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joycelyn","family":"Ashby Cornthwaite","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6833-5059","authenticated-orcid":false,"given":"Ghamar","family":"Bitar","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pedroza","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Evidence-Based Medicine, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneet P.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Delaware Center of Maternal-Fetal Medicine at Christiana Care, Department of Obstetrics, Gynecology, and Reproductive Sciences, Newark, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Saade","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha M.","family":"Sibai","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Data from: Trends and characteristics in gestational diabetes: United States, 2016\u20132020","volume":"71","author":"E Gregory","year":"2022","journal-title":"Natl Vital Stat Rep"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1001\/jama.2021.7217","article-title":"Trends in gestational diabetes at first live birth by race and ethnicity in the US, 2011-2019","volume":"326","author":"N S 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