{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T23:10:09Z","timestamp":1746486609943,"version":"3.40.4"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Differenzierung von benignen und malignen Halszysten stellt f\u00fcr den HNO-Arzt eine Herausforderung dar. Die Inzidenz von Karzinomen in initial benigne eingestuften Halszysten liegt bei bis zu 24%. Das Ziel dieser Studie war es, \u00fcber die Malignit\u00e4tsrate von zystischen zervikalen L\u00e4sionen zu berichten und mittels aktueller Leitlinien eine Differenzierung von zervikalen Metastasen im Vergleich zu benignen Halszysten zu erleichtern.<\/jats:p><jats:p>Zwischen 2013 und 2023 wurden insgesamt 155 Patienten mit der Verdachtsdiagnose einer lateralen Halszyste in der Abteilung f\u00fcr Hals-, Nasen- und Ohrenheilkunde des Universit\u00e4tsklinikums Heidelberg behandelt. Bei allen Patienten wurde eine Zystenexstirpation mit oder ohne Panendoskopie durchgef\u00fchrt.<\/jats:p><jats:p>Bei 21,9% der Patienten zeigte sich histologisch eine Lymphknotenmetastase ipsilateral zum Primarius. Das Durchschnittsalter dieser Patienten lag statistisch signifikant h\u00f6her als das der Patienten mit benignen L\u00e4sionen (64,0\u00b112,8 versus 41,0\u00b115,8; p&lt;0,001). W\u00e4hrend die Wahrscheinlichkeit einer Malignit\u00e4t bei Patienten unter 54 Jahren selten war (11%), stieg sie in der Altersgruppe von 60\u201369 Jahren auf 80% an. Die klinische Sensitivit\u00e4t bei Initialverdacht einer benignen Halszyste lag bei 60,3%, die Spezifit\u00e4t bei 48,7%.<\/jats:p><jats:p>Zur fr\u00fchzeitigen Diagnose und Therapie einer unilateralen Halszyste geh\u00f6rt eine individuelle Vorgehensweise, welche durch multiple Faktoren (Anamnese, klinische Befunde, Bildgebung sowie klinikeigene Kompetenzen) getroffen werden muss. Unabh\u00e4ngig davon empfehlen wir bei Patienten \u00fcber 40 Jahren ein bildmorphologisches Staging, eine \u201eNo-touch\u201c-Panendoskopie und eine histologische Sicherung.<\/jats:p>","DOI":"10.1055\/a-2496-2775","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:13:43Z","timestamp":1736468023000},"page":"296-303","source":"Crossref","is-referenced-by-count":0,"title":["Differenzierung von benignen und malignen Halszysten \u2013 eine diagnostische Herausforderung"],"prefix":"10.1055","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7709-2395","authenticated-orcid":false,"given":"Christina","family":"Sauter","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4t Augsburg, Augsburg, Germany"},{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- Halschirurgie, Universit\u00e4t Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Sand","sequence":"additional","affiliation":[{"name":"GESIS, GESIS \u2013 Leibniz-Institut f\u00fcr Sozialwissenschaften in Mannheim, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Plath","sequence":"additional","affiliation":[{"name":"HNO, Praxis f\u00fcr Hals-, Nasen- und Ohrenheilkunde Bensheim, Bensheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela Maria","family":"Plath","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- Halschirurgie, Universit\u00e4t Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/dc.10201","article-title":"Cystic change in 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