{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:24:15Z","timestamp":1774581855906,"version":"3.50.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012112","name":"Sobi","doi-asserted-by":"crossref","award":["NCT04731701"],"award-info":[{"award-number":["NCT04731701"]}],"id":[{"id":"10.13039\/501100012112","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Hemophilia Functional Ability Scoring Tool (Hemo-FAST), consisting of a patient-reported outcome (PRO) part and a clinician-reported outcome (ClinRO) part, was developed as a rapid and effective tool to assess functional mobility in clinical practice. This study (NCT04731701) aimed to validate the psychometric properties of Hemo-FAST for assessment of joint health in people with haemophilia (PwH).<\/jats:p><jats:p>PwH A or B aged \u226518 years completed questionnaires including the PRO part of Hemo-FAST and the short-form 36 health survey (SF-36) during one study visit. Clinicians completed the Haemophilia Joint Health Score (HJHS) and the ClinRO part of Hemo-FAST at the same visit. Validation was performed using reliability, construct validity, and structure validity assessments.<\/jats:p><jats:p>The study enrolled 180 PwH A or B from 14 centres across France. Estimated time to complete the PRO part was mean (standard deviation) 4.6 (5.4) minutes. PRO items showed good test\u2013retest reliability (intraclass correlation coefficient value \u22650.70). Inter-rater values were &gt;0.70 for 7\/9 ClinRO items, indicating good reliability. All items (15 PRO; 9 ClinRO) had high internal consistency (Cronbach's coefficient alpha: 0.97). Hemo-FAST demonstrated convergent construct validity with HJHS and the SF-36 physical component and discriminant construct validity with the SF-36 mental health component. Hemo-FAST scores distinguished between subgroups of people with expected differences in joint health status, including by haemophilia severity (p\u2009&lt;\u20090.0001).<\/jats:p><jats:p>This study successfully validated Hemo-FAST as a rapid and reliable tool for the functional assessment of joint health in adults with haemophilia, both in clinical practice and clinical research settings.<\/jats:p>","DOI":"10.1055\/a-2501-1369","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T19:23:48Z","timestamp":1737487428000},"page":"960-971","source":"Crossref","is-referenced-by-count":1,"title":["Psychometric Validation of the Hemophilia Functional Ability Scoring Tool (Hemo-FAST)"],"prefix":"10.1055","volume":"125","author":[{"given":"Virginie","family":"Barbay","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre, University Hospital of Rouen Normandie, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohann","family":"Repess\u00e9","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre CRC-MHC, University Hospital of Caen Normandie, Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Desprez","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre, CHU Strasbourg, Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Drillaud","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre CRC-MHC, University Hospital, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Frotscher","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre, University Hospital, Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-L\u00e9a","family":"Piel-Julian","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Center, University Hospital, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Castet","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre, University Hospital, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Genre-Volot","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre, University Hospital, Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Tardy","sequence":"additional","affiliation":[{"name":"CRC H\u00e9mophilie, CIC Inserm 1408 CHU St Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Harroche","sequence":"additional","affiliation":[{"name":"Centre de Ressources et de Comp\u00e9tences Maladies H\u00e9morragiques Constitutionnelles, H\u00f4pital Universitaire Necker-Enfants Malades, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Gandossi","sequence":"additional","affiliation":[{"name":"Medical Affairs, Sobi, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriem","family":"Zidi","sequence":"additional","affiliation":[{"name":"Medical Affairs, Sobi, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Clinical Study Management, Sobi, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Kragh","sequence":"additional","affiliation":[{"name":"Global HEOR, Sobi, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Bednar","sequence":"additional","affiliation":[{"name":"Global Medical Affairs and Clinical Development, Sobi, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"N\u00e9grier","sequence":"additional","affiliation":[{"name":"University Lyon 1, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lien","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Centre de Ressources et Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles, CHU Clermont-Ferrand, Estaing Hospital, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"issue":"S 06","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH Guidelines for the Management of Hemophilia, 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