{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:14:47Z","timestamp":1743480887759,"version":"3.40.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Obwohl Impfstoffe zur Verf\u00fcgung stehen, ist die H\u00e4ufigkeit von Sepsisf\u00e4llen mit Streptococcus pneumoniae immer noch recht hoch.<\/jats:p><jats:p>In den Jahren von 2015\u20132022 wurden bei 925 in unserem Labor untersuchten Blutkulturen Streptococcus pneumoniae nachgewiesen. Von einem Gro\u00dfteil, n\u00e4mlich von 754 St\u00e4mmen, wurde der Serotyp bestimmt. Au\u00dferdem wurde deren in-vitro-Empfindlichkeit gegen einige Antibiotika getestet.<\/jats:p><jats:p>Die Isolate stammten \u00fcberwiegend von \u00e4lteren Menschen (&gt;60 Jahre), und zwar h\u00e4ufiger von M\u00e4nnern als von Frauen. In den Jahren 2020 und 2021 wurden deutlich weniger F\u00e4lle von Pneumokokken-Sepsis verzeichnet, was vermutlich auf den nicht pharmazeutischen Ma\u00dfnahmen zur Pr\u00e4vention aerogen \u00fcbertragener Infektionen w\u00e4hrend der Coronapandemie (Schutzmasken, Abstand halten) beruht. Kinder im Alter bis zu einem Jahr waren auch relativ anf\u00e4llig. Die Serotypen 3 und 8 dominierten. In dem 20-valenten Konjugat-Impfstoff waren 67% der gefundenen Serotypen enthalten und 75% in dem reinen Polysaccharid-Impfstoff. Die \u00fcberwiegende Mehrzahl der Isolate war gegen Penicillin, Erythromycin und auch gegen Doxycyclin empfindlich. Multi-drug-resistente St\u00e4mme wurden nicht beobachtet.<\/jats:p><jats:p>Eine Impfung h\u00e4tte einen Gro\u00dfteil der Infektionen vermutlich verhindern k\u00f6nnen. Zu beachten ist jedoch, dass immerhin 27% der gefundenen Serotypen in keinem der angebotenen Impfstoffe enthalten sind.<\/jats:p>","DOI":"10.1055\/a-2506-4928","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:20:11Z","timestamp":1740183611000},"page":"e11-e17","source":"Crossref","is-referenced-by-count":0,"title":["Pneumokokkensepsis 2015\u20132022: \u00dcberlegungen zu Impfstrategien"],"prefix":"10.1055","volume":"150","author":[{"given":"Herbert","family":"Hof","sequence":"additional","affiliation":[{"name":"MVZ Labor Limbach u. Kollegen, Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Singer","sequence":"additional","affiliation":[{"name":"MVZ Labor Limbach u. Kollegen, Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ika","family":"Steiner","sequence":"additional","affiliation":[{"name":"MVZ Labor Limbach u. Kollegen, Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Bertsch","sequence":"additional","affiliation":[{"name":"MVZ Labor Limbach u. Kollegen, Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kirstahler","sequence":"additional","affiliation":[{"name":"MVZ Labor Limbach u. Kollegen, Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Oberdorfer","sequence":"additional","affiliation":[{"name":"MVZ Labor Limbach u. Kollegen, Heidelberg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Im\u00f6hl","sequence":"additional","affiliation":[{"name":"Referenzlabor Streptokokken, Institut f\u00fcr Medizinische Mikrobiologie, Universit\u00e4tsklinikum RWTH Aachen,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Referenzlabor Streptokokken, Institut f\u00fcr Medizinische Mikrobiologie, Universit\u00e4tsklinikum RWTH Aachen,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"volume-title":"unter Mitarbeit von Bruder D., Cornely O., Geginat G et al. Medizinische Mikrobiologie, Duale Reihe","year":"2022","key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1055\/s-0031-1292842","article-title":"Pneumokokkensepsis im Alter \u2013 Implikationen f\u00fcr die Impfung alter Menschen gegen Pneumokokken","volume":"136","author":"H Hof","year":"2011","journal-title":"Dtsch Med Wochenschr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00391-012-0339-x","article-title":"Pneumokokkeninfektionen im Alter \u2013 impfpr\u00e4ventabel!","volume":"46","author":"H Hof","year":"2013","journal-title":"Z f Gerontol Geriat"},{"key":"ref4","first-page":"1","article-title":"Aktualisierung der Empfehlungen zur Pneumokokken-Impfung","volume":"39","author":"STIKO","year":"2023","journal-title":"Epid Bull"},{"key":"ref5","first-page":"13","volume-title":"Antimicrobial resistance among Streptococcus pneumoniae","author":"C Cill\u00f3niz","year":"2018"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1016\/S2589-7500(21)00077-7","article-title":"Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data","volume":"3","author":"AB Brueggemann","year":"2021","journal-title":"Lancet Digit Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e1154","DOI":"10.1093\/cid\/ciab1014","article-title":"Decline in pneumococcal disease in young children during the Coronavirus disease 2019 (COVID-19) pandemic in Israel associated with suppression of seasonal respiratory viruses, despite persistent pneumococcal carriage: a prospective cohort study","volume":"75","author":"D Danino","year":"2022","journal-title":"Clin Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1016\/S2589-7500(23)00108-5","article-title":"Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS consortium","volume":"5","author":"D Shaw","year":"2023","journal-title":"Lancet Digit Health"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"100126","DOI":"10.1016\/j.lanepe.2021.100126","article-title":"Pneumococcal vaccine uptake and vaccine effectiveness in older adults with invasive pneumococcal disease in Germany: A retrospective cohort study","volume":"7","author":"S Perniciaro","year":"2021","journal-title":"Lancet Reg Health Eur"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"6310","DOI":"10.1016\/j.vaccine.2019.08.059","article-title":"Pneumococcal conjugate vaccine against serotype 3 pneumococcal pneumonia in adults: a systematic review and pooled analysis","volume":"37","author":"JM McLaughlin","year":"2019","journal-title":"Vaccine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"613287","DOI":"10.3389\/fcimb.2020.613287","article-title":"Sugar-Coated killer: serotype 3 pneumococcal disease","volume":"10","author":"JN Luck","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref12","first-page":"6","article-title":"Impfquoten von Kinderschutzimpfungen in Deutschland \u2013 aktuelle Ergebnisse aus der RKI-Impfsurveillance","volume":"49","author":"T Rieck","year":"2021","journal-title":"Epid Bull"},{"key":"ref13","first-page":"3","article-title":"Impfquoten bei Erwachsenen in Deutschland \u2013 Aktuelles aus der KV-Impfsurveillance","volume":"50","author":"T Rieck","year":"2021","journal-title":"Epid Bull"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s41479-022-00097-y","article-title":"The remarkable history of pneumococcal vaccination: an ongoing challenge","volume":"14","author":"DM Musher","year":"2022","journal-title":"Pneumonia"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"949469","DOI":"10.3389\/fcimb.2022.949469","article-title":"Non-capsular based immunization approaches to prevent Streptococcus pneumoniae infection. Front","volume":"12","author":"PH Silva","year":"2022","journal-title":"Cell Infect Microbiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00108-021-01100-2","article-title":"Pneumokokkenimpfstoffe","volume":"62","author":"MW Pletz","year":"2021","journal-title":"Internist"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.gpp3-0028-2018","article-title":"Pneumococcal vaccines","volume":"7","author":"DE Briles","year":"2019","journal-title":"Microbiol Spectrum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s15006-021-0492-5","article-title":"Praxisrelevante \u00dcberlegungen zur Pneumokokken-Impfung im Alter","volume":"163","author":"H Heppner","year":"2021","journal-title":"MMW \u2013 Fortschritte der Medizin"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/infdis\/jis212","article-title":"Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells","volume":"205","author":"EA Clutterbuck","year":"2012","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1586\/erv.11.8","article-title":"Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines","volume":"10","author":"J Poolman","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"7977","DOI":"10.1016\/j.vaccine.2020.10.042","article-title":"Pneumococcal conjugate vaccine primes mucosal immune responses to pneumococcal polysaccharide vaccine booster in Papua New Guinean children","volume":"38","author":"T Orami","year":"2020","journal-title":"Vaccine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-2008-1046719","article-title":"Pneumokokkenimpfung: Konjugatimpfstoff induziert Herdenimmunit\u00e4t und reduziert Antibiotikaresistenz","volume":"133","author":"MW Pletz","year":"2008","journal-title":"Dtsch Med Wochenschr"},{"key":"ref23","first-page":"633","article-title":"Stellungnahme zur Empfehlung der Pneumokokken-Impfung f\u00fcr Erwachsene. Positionspapier der Deutschen Gesellschaft f\u00fcr Pneumologie und Beatmungs-Medizin (DGP) und der Deutschen Gesellschaft f\u00fcr Geriatrie (DGG)","volume":"69","author":"MW Pletz","year":"2015","journal-title":"Pneumologie"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2506-4928.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T22:46:44Z","timestamp":1743461204000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2506-4928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":23,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2025,3,31]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2506-4928","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"type":"print","value":"0012-0472"},{"type":"electronic","value":"1439-4413"}],"subject":[],"published":{"date-parts":[[2025,2,21]]}}}