{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:19:35Z","timestamp":1789154375528,"version":"build-2803163510"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Zwei Patientinnen stellten sich kurz nacheinander in unserer Klinik vor\u2013mit Sehst\u00f6rungen, Sehen von Doppelbildern, Schluckst\u00f6rungen und Luftnot, wenige Tage nach intragastraler Injektion von Botulinumtoxin in einer Klinik in der T\u00fcrkei.<\/jats:p><jats:p>Die k\u00f6rperliche Untersuchung war bis auf Hinweise auf eine respiratorische Insuffizienz mit erh\u00f6hter Atemfrequenz und Luftnot vor allem im Liegen unauff\u00e4llig, eindeutige neurologische Symptome fanden sich nicht. In der Bildgebung fanden sich Hinweise auf eine verminderte Zwerchfell-Beweglichkeit. Die Blutgas-Analysen zeigten eine hypox\u00e4mische respiratorische Insuffizienz.<\/jats:p><jats:p>Die Patientinnen wurden ohne spezifische Therapie einige Tage lang station\u00e4r beobachtet und mit r\u00fcckl\u00e4ufiger Symptomatik entlassen.<\/jats:p><jats:p>Im M\u00e4rz 2023 ver\u00f6ffentlichten das Robert-Koch-Institut, das European Centre for Disease Prevention and Control und die WHO einen Bericht \u00fcber 87 Patienten, die in 2 t\u00fcrkischen Krankenh\u00e4usern mit dem Ziel einer Gewichtsreduktion intragastrale Injektionen von Botulinumtoxin erhalten und nachfolgend Symptome eines Botulismus entwickelt hatten. Die beiden hier vorgestellten F\u00e4lle verdeutlichen die Problematik der weiterhin durchgef\u00fchrten Prozedur und die Risiken eines Botulismus.<\/jats:p>","DOI":"10.1055\/a-2506-6699","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:37:16Z","timestamp":1744155436000},"page":"504-507","source":"Crossref","is-referenced-by-count":1,"title":["Neue F\u00e4lle von Botulismus nach intragastraler Injektion von Botulinum-Neurotoxin"],"prefix":"10.1055","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9647-1548","authenticated-orcid":false,"given":"Werner","family":"Beermann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Agaplesion Klinikum Hagen gGmbH, Hagen, GERMANY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.5152\/tjg.2020.20076","article-title":"Gastric Botulinum Toxin-A Application for Weight Loss Therapy","volume":"32","author":"O \u015een","year":"2021","journal-title":"Turk J Gastroenterol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.clnu.2020.10.008","article-title":"Endoscopic intragastric injection of botulinum toxin A in obese patients on bariatric surgery waiting lists: A randomised double-blind study (IntraTox study)","volume":"40","author":"FJ S\u00e1nchez Torralvo","year":"2021","journal-title":"Clin Nutr"},{"issue":"06","key":"ref3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/jgh.15847","article-title":"Intragastric injection of botulinum toxin A for weight loss: A systematic review and meta-analysis of randomized controlled trials","volume":"37","author":"YA Yen","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"issue":"10","key":"ref4","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1007\/s11695-020-04842-4","article-title":"Intragastric botulinum toxin A injection is an effective obesity therapy for patients with BMI > 40 kg\/m\u00b2: a systematic review and meta-analysis","volume":"30","author":"PC Chang","year":"2020","journal-title":"Obes Surg"},{"issue":"23","key":"ref8","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.23.2300203","article-title":"A large travel-associated outbreak of iatrogenic botulism in four European countries following intragastric botulinum neurotoxin injections for weight reduction, T\u00fcrkiye, February to March 2023","volume":"28","author":"MB Dorner","year":"2023","journal-title":"Euro Surveill"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2023.101152","article-title":"Outbreaks of iatrogenic botulism in Europe: Combating off-label medical use of Botulinum Neurotoxin (BoNT) in bariatric procedures","volume":"53","author":"N Jain","year":"2023","journal-title":"New Microbes New Infect"},{"issue":"03","key":"ref10","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3855\/jidc.18868","article-title":"Iatrogenic botulism cases after gastric and axillary application of botulinum toxin and review of literature","volume":"18","author":"F Eser","year":"2024","journal-title":"J Infect Dev Ctries"},{"issue":"02","key":"ref11","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.23.0625","article-title":"Iatrogenic botulism","volume":"144","author":"G Hagberg","year":"2024","journal-title":"Tidsskr Nor Laegeforen"},{"issue":"23","key":"ref12","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.23.2300280","article-title":"Lessons from a recent multicountry iatrogenic botulism outbreak","volume":"28","author":"F Anniballi","year":"2023","journal-title":"Euro Surveill"},{"issue":"10","key":"ref13","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1111\/ene.16005","article-title":"Iatrogenic systemic botulism after intragastric botulinum neurotoxin injection: Case report","volume":"30","author":"BB K\u0131lboz","year":"2023","journal-title":"Eur J Neurol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8183127","article-title":"Intragastric Botulinum Toxin Injection and Botulism: An Alarm for Clinicians","volume":"2024","author":"M Mojtahedzadeh","year":"2024","journal-title":"Case Rep Crit Care"},{"issue":"10","key":"ref15","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1007\/s11695-017-2857-5","article-title":"Obesity treatment with botulinum toxin-A is not effective: a systematic review and meta-analysis","volume":"27","author":"F Bustamante","year":"2017","journal-title":"Obes Surg"}],"container-title":["DMW - 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