{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:15:27Z","timestamp":1792718127354,"version":"4.5.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of subclinical inflammation and have been associated with prognosis and mortality in many diseases. In this study, we evaluated the comparative value of NLR and PLR in identifying high mortality risk in patients hospitalized with acute pulmonary thromboembolism (PTE), and their relationship with the anatomical burden of thrombus.<\/jats:p><jats:p>Patients who were followed up due to PTE were evaluated retrospectively. NLR and PLR were calculated from complete blood counts. The thrombus burden was assessed by the Qanadli score; based on the patients' archival computed tomography angiography images. Mortality prediction was based on an algorithm using the Pulmonary Embolism Severity Index, echocardiographic findings, and troponin levels.<\/jats:p><jats:p>Three hundred-two PTE patients were included in the study. Median NLR, PLR, and Qanadli score values were higher in nonsurvivors, with NLR (8.4 [2.2\u201318.9]) vs. (3.1 [0.4\u201313.1]), PLR (317 [87.6\u2013525.3]) vs. (124.4 [30\u2013476.3]), and Qanadli scores (21 [3\u201326]) vs. (9 [1\u201328]), respectively (p\u2009&lt;\u20090.001). We showed that setting a threshold value of &gt;4.45 for NLR and &gt;151.59 for PLR significantly predicts the high mortality-risk group. In the receiver operating characteristic analysis, when the threshold value for the Qanadli score distinguishing between low-risk and high-risk disease was set at 15.5, the sensitivity was calculated as 98.8% and the specificity was 94.9% (p\u2009=\u20090.001).<\/jats:p><jats:p>This study showed that NLR, PLR, and Qanadli scores can provide essential contributions to the clinician's determination of the anatomical burden of thrombus and disease severity in PTE patients.<\/jats:p>","DOI":"10.1055\/a-2506-6705","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T23:53:21Z","timestamp":1743206001000},"source":"Crossref","is-referenced-by-count":3,"title":["Correlation between Platelet-to-Lymphocyte Ratio, Neutrophil-to-Lymphocyte Ratio and Burden of Thrombus with Disease Severity in Patients with Pulmonary Thromboembolism"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-7419","authenticated-orcid":false,"given":"Ayshan","family":"Mammadova","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Lokman Hekim University Akay Hospital, \u00c7ankaya, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-9882","authenticated-orcid":false,"given":"K\u00fcbra","family":"Ta\u015fkaraca","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-0700","authenticated-orcid":false,"given":"G\u00fcnel","family":"Jeyranova","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9369-7026","authenticated-orcid":false,"given":"Aysel","family":"Orujlu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7882-2943","authenticated-orcid":false,"given":"Merve","family":"Tatl\u0131l\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2052-6516","authenticated-orcid":false,"given":"Serra","family":"Duygulu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-7116","authenticated-orcid":false,"given":"Zeynep","family":"Yal\u00e7\u0131nkaya","sequence":"additional","affiliation":[{"name":"Department of Public Health, Afyonkarahisar Community Health Center, Afyon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-5978","authenticated-orcid":false,"given":"Seriyye","family":"Allahverdiyeva","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-9257","authenticated-orcid":false,"given":"Onur","family":"G\u00fcndo\u011fdu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-8397","authenticated-orcid":false,"given":"Atiye Cenay Karab\u00f6rk","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-9232","authenticated-orcid":false,"given":"Sevcihan Kesen","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-9386","authenticated-orcid":false,"given":"Gonca","family":"Erba\u015f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-5455","authenticated-orcid":false,"given":"\u0130.K\u0131v\u0131lc\u0131m","family":"O\u011fuz\u00fclgen","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"42","key":"ref1","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1093\/eurheartj\/ehz726","article-title":"The 2019 ESC Guidelines on the Diagnosis and Management of Acute Pulmonary Embolism","volume":"40","author":"S V Konstantinides","year":"2019","journal-title":"Eur Heart J"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"e0260802","DOI":"10.1371\/journal.pone.0260802","article-title":"Time efficiency and reliability of established computed tomographic obstruction scores in patients with acute pulmonary embolism","volume":"16","author":"H J Meyer","year":"2021","journal-title":"PLoS One"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pcad.2017.12.005","article-title":"Pulmonary embolism: care standards in 2018","volume":"60","author":"A Borohovitz","year":"2018","journal-title":"Prog Cardiovasc Dis"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.21037\/qims-21-140","article-title":"Clot burden of acute pulmonary thromboembolism: comparison of two deep learning algorithms, Qanadli score, and Mastora score","volume":"12","author":"H Zhang","year":"2022","journal-title":"Quant Imaging Med Surg"},{"issue":"09","key":"ref5","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2021.201130","article-title":"Compare the Diagnostic and Prognostic Value of MLR, NLR and PLR in CRC Patients","volume":"67","author":"Y Kang","year":"2021","journal-title":"Clin Lab"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13048-023-01116-2","article-title":"Independent predictive value of blood inflammatory composite markers in ovarian cancer: recent clinical evidence and perspective focusing on NLR and PLR","volume":"16","author":"C L Zhang","year":"2023","journal-title":"J Ovarian Res"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1007\/s10067-018-4194-z","article-title":"Neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio in Beh\u00e7et's disease: which and when to use?","volume":"37","author":"M Hammad","year":"2018","journal-title":"Clin Rheumatol"},{"issue":"04","key":"ref8","first-page":"1185","article-title":"Significance of Neutrophil\/Lymphocyte Ratio and Platelet\/Lymphocyte Ratio in Patients with Multiple Myeloma","volume":"27","author":"J Y Sun","year":"2019","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"01","key":"ref9","first-page":"24","article-title":"Role of platelet-lymphocyte ratio in prediction of long-term mortality in patients with type A acute aortic dissection","volume":"20","author":"M M Tabakac\u0131","year":"2017","journal-title":"Kosuyolu Heart J"},{"issue":"09","key":"ref10","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/jmv.25767","article-title":"Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19","volume":"92","author":"R Qu","year":"2020","journal-title":"J Med Virol"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"e22072","DOI":"10.1002\/jcla.22072","article-title":"Diagnostic validity of hematologic parameters in evaluation of massive pulmonary embolism","volume":"31","author":"H Ates","year":"2017","journal-title":"J Clin Lab Anal"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e00397","DOI":"10.1016\/j.plabm.2024.e00397","article-title":"Beyond the fractures: a comprehensive comparative analysis of affordable and accessible laboratory parameters and their coefficients for prediction and Swift confirmation of pulmonary embolism in high-risk orthopedic patients","volume":"40","author":"P Piech","year":"2024","journal-title":"Pract Lab Med"},{"issue":"04","key":"ref13","first-page":"952","article-title":"Correlation of computerized tomography angiographic pulmonary artery obstruction score with hematologic outcome and mortality in patients with acute pulmonary embolism","volume":"33","author":"M Ye\u015filda\u011f","year":"2013","journal-title":"Turk Klin J Med Sci"},{"issue":"15","key":"ref14","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1001\/archinternmed.2010.199","article-title":"Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism","volume":"170","author":"D Jim\u00e9nez","year":"2010","journal-title":"Arch Intern Med"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.18502\/jovr.v15i2.6737","article-title":"Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with retinal artery occlusion","volume":"15","author":"M Atum","year":"2020","journal-title":"J Ophthalmic Vis Res"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ajem.2019.10.023","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: a meta-analysis","volume":"38","author":"Z Huang","year":"2020","journal-title":"Am J Emerg Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"686983","DOI":"10.3389\/fneur.2021.686983","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in stroke: a systematic review and meta-analysis","volume":"12","author":"W Li","year":"2021","journal-title":"Front Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cca.2020.04.024","article-title":"Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China","volume":"507","author":"S Sun","year":"2020","journal-title":"Clin Chim Acta"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"e14781","DOI":"10.1111\/ijcp.14781","article-title":"Role of NLR, PLR, ELR and CLR in differentiating COVID-19 patients with and without pneumonia","volume":"75","author":"T Damar \u00c7ak\u0131rca","year":"2021","journal-title":"Int J Clin Pract"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/17476348.2019.1675517","article-title":"Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients","volume":"14","author":"A G El-Gazzar","year":"2020","journal-title":"Expert Rev Respir Med"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3892\/ijmm.2023.5255","article-title":"Platelet\u2013to\u2013lymphocyte ratio, neutrophil\u2013to\u2013lymphocyte ratio and monocyte\u2013to\u2013HDL cholesterol ratio as helpful biomarkers for patients hospitalized for deep vein thrombosis","volume":"51","author":"S Selvaggio","year":"2023","journal-title":"Int J Mol Med"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5578\/tt.68519","article-title":"Comparison of neutrophil to lymphocyte ratio with other prognostic markers affecting 30 day mortality in acute pulmonary embolism","volume":"67","author":"U S Kasapo\u011flu","year":"2019","journal-title":"Tuberk Toraks"},{"issue":"18","key":"ref23","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.3390\/jcm10184058","article-title":"The prognostic role of neutrophil-to-lymphocyte ratio in patients hospitalized with acute pulmonary embolism","volume":"10","author":"O Efros","year":"2021","journal-title":"J Clin Med"},{"issue":"01","key":"ref24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.23736\/S0392-9590.18.04028-2","article-title":"The relationship between platelet-to-lymphocyte ratio and pulmonary embolism severity in acute pulmonary embolism","volume":"38","author":"S Telo","year":"2019","journal-title":"Int Angiol"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.hrtlng.2015.04.007","article-title":"The relation between platelet-to-lymphocyte ratio and pulmonary embolism severity index in acute pulmonary embolism","volume":"44","author":"H Kundi","year":"2015","journal-title":"Heart Lung"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2214\/ajr.176.6.1761415","article-title":"New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography","volume":"176","author":"S D Qanadli","year":"2001","journal-title":"AJR Am J Roentgenol"},{"issue":"04","key":"ref27","first-page":"247","article-title":"Correlation of thrombosed vessel location and clot burden score with severity of disease and risk stratification in patients with acute pulmonary embolism","volume":"24","author":"I Irmak","year":"2020","journal-title":"Anatol J Cardiol"},{"issue":"11","key":"ref28","first-page":"687","article-title":"Clot burden score in the evaluation of right ventricular dysfunction in acute pulmonary embolism: quantifying the cause and clarifying the consequences [in Portuguese]","volume":"31","author":"B Rodrigues","year":"2012","journal-title":"Rev Port Cardiol"},{"issue":"06","key":"ref29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ihj.2014.10.405","article-title":"Study of clinical, radiological and echocardiographic features and correlation of Qanadli CT index with RV dysfunction and outcomes in pulmonary embolism","volume":"66","author":"B S Praveen Kumar","year":"2014","journal-title":"Indian Heart J"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4103\/1817-1737.191868","article-title":"Diagnostic implications of computed tomography pulmonary angiography in patients with pulmonary embolism","volume":"11","author":"A El-Menyar","year":"2016","journal-title":"Ann Thorac Med"}],"container-title":["H\u00e4mostaseologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2506-6705.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T23:54:14Z","timestamp":1743206054000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2506-6705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1055\/a-2506-6705","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0720-9355","2567-5761"],"issn-type":[{"value":"0720-9355","type":"print"},{"value":"2567-5761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]}}}