{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:39:44Z","timestamp":1784957984608,"version":"3.55.0"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Measurement-based care (MBC) involves systematically assessing patients\u02bc\n                        symptoms and adverse events using standardized scales to guide treatment.\n                        While MBC has been shown to enhance the quality of care and outcomes in the\n                        pharmacotherapy of major depressive disorder (MDD), it is still rarely used\n                        in clinical practice. In this study, the feasibility of implementing MBC was\n                        assessed for patients with MDD seen in a large outpatient psychiatry\n                        clinic.<\/jats:p><jats:p>Adults diagnosed with MDD were assessed at baseline and during a 12-week\n                        follow-up by phone or via emailed links with: the 9-item Patient Health\n                        Questionnaire (PHQ-9), an adverse effect rating scale, and a published\n                        suicide risk management protocol (SRMP). Antidepressants were recommended\n                        based on preferences expressed by the participant and treating psychiatrist;\n                        dosages were adjusted by the treating psychiatrist based on symptomatic\n                        improvement and adverse events.<\/jats:p><jats:p>Over 2 years, 52 (21.2%) of 246 patients referred to the study were enrolled,\n                        28 (53.8%) completed all assessments at all follow-up visits, 45 (87.0%)\n                        participants were prescribed one of the recommended antidepressants, and 22\n                        (42.3%) remitted. Of the 27 participants presenting with suicidal ideation,\n                        18 (66.6%) experienced a full resolution of these ideations.<\/jats:p><jats:p>These findings highlight the challenges in implementing MBC for the\n                        pharmacotherapy of MDD and confirm some barriers to its broad adoption in\n                        clinical practice. The study also highlights its benefits in the selected\n                        group of patients who engage in MBC. Future studies need to continue to\n                        explore innovative ways to facilitate its broader implementation.<\/jats:p>","DOI":"10.1055\/a-2508-5757","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T19:29:46Z","timestamp":1740511786000},"page":"170-177","source":"Crossref","is-referenced-by-count":4,"title":["Challenges Related to the Implementation of Measurement-Based Care\n                    for the Treatment of Major Depressive Disorder: A Feasibility\n                    Study"],"prefix":"10.1055","volume":"58","author":[{"given":"Emytis","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Xiang","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed I.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Blumberger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kloiber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Perivolaris","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto,Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/wps.20388","article-title":"Has increased provision of treatment reduced the prevalence of common mental\n                    disorders? 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