{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:03:09Z","timestamp":1764306189811,"version":"3.46.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A subgroup of patients with acute depression show an impaired regulation of\n                        the hypothalamic-pituitary-adrenocortical axis, which can be sensitively\n                        diagnosed with the combined dexamethasone (dex)\/corticotropin releasing\n                        hormone (CRH)\u2013test. This neuropathological alteration is assumed to be a\n                        result of hyperactive AVP\/V1b signalling. Given the complicated procedure of\n                        the dex\/CRH-test, this study aimed to develop a genetic variants-based\n                        alternative approach to predict the outcome of the dex\/CRH-test in acute\n                        depression.<\/jats:p>\n                  <jats:p>Using data of a representative cohort of 352 patients with severe depression\n                        participating in the dex\/CRH-test, a genome-wide interaction analysis was\n                        performed starting with an anchor single nucleotide polymorphism located in\n                        the upstream transcriptional region of the human V1b-receptor gene to\n                        predict the adrenocorticotropic hormone (ACTH) response to this test. A\n                        probabilistic neural-network-algorithm was used to develop the optimal\n                        prediction model.<\/jats:p>\n                  <jats:p>Overall prediction accuracy for correctly identifying high ACTH responders in\n                        the dex\/CRH-test was 93.5% (sensitivity 90%; specificity 95%). Analysis of\n                        pituitary RNAseq expression data confirmed that the identified genetic\n                        interactions of the gene test translate into an interactive network of\n                        corresponding transcripts in the pituitary gland, which is the biologically\n                        relevant target tissue, with the aggregated strength of the transcript\n                        interactions significantly stronger than expected from chance.<\/jats:p>\n                  <jats:p>The findings suggest the suitability of the presented gene test as a proxy\n                        for hyperactive AVP\/V1b signalling during an acute depressive episode,\n                        highlighting its potential as companion test for identifying patients with\n                        acute depression whose pathology can be optimally treated by specific drugs\n                        targeting the AVP\/V1b-signaling cascade.<\/jats:p>","DOI":"10.1055\/a-2508-5834","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:47:52Z","timestamp":1738176472000},"page":"132-138","source":"Crossref","is-referenced-by-count":1,"title":["Development of a Genetic Test Indicating Increased AVP\/V1b Signalling\n                    in Patients with Acute Depression"],"prefix":"10.1055","volume":"58","author":[{"given":"Marcus","family":"Ising","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Holsboer","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry, Munich, Germany"},{"name":"HMNC Holding GmbH, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Myhsok","sequence":"additional","affiliation":[{"name":"HMNC Holding GmbH, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertram","family":"M\u00fcller-Myhsok","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry, Munich, Germany"},{"name":"HMNC Holding GmbH, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"volume-title":"Mental illnesses prevalence, World, 2021. Our World in Data","year":"2024","author":"M Roser","key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.psyneuen.2008.03.008","article-title":"The link between childhood trauma and depression: Insights from HPA axis studies\n                    in humans","volume":"33","author":"C Heim","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1037\/rev0000157","article-title":"Life stress and major depression: The mysteries of recurrences","volume":"126","author":"S M Monroe","year":"2019","journal-title":"Psychol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/10615806.2015.1005078","article-title":"Negative life events and symptoms of depression and anxiety: Stress causation\n                    and\/or stress generation","volume":"28","author":"A C Phillips","year":"2015","journal-title":"Anxiety Stress Coping"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/S0006-3223(99)00224-3","article-title":"The impact of early adverse experiences on brain systems involved in the\n                    pathophysiology of anxiety and affective disorders","volume":"46","author":"C Heim","year":"1999","journal-title":"Biol Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: From adaptation to disease","volume":"6","author":"E R de Kloet","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.psych.093008.100321","article-title":"Stress hormone regulation: Biological role and translation into therapy","volume":"61","author":"F Holsboer","year":"2010","journal-title":"Annu Rev Psychol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-819973-2.00003-4","article-title":"Hypothalamic stress systems in mood disorders","volume":"182","author":"F Holsboer","year":"2021","journal-title":"Handb Clin Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0022-3956(94)90017-5","article-title":"The combined dexamethasone\/CRH test: A refined laboratory test for psychiatric\n                    disorders","volume":"28","author":"I J Heuser","year":"1994","journal-title":"J Psychiatr Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.pnpbp.2005.03.014","article-title":"The combined dexamethasone\/CRH test as a potential surrogate marker in\n                    depression","volume":"29","author":"M Ising","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/0024-3205(85)90480-1","article-title":"Combined administration of human corticotropin-releasing factor and lysine\n                    vasopressin induces cortisol escape from dexamethasone suppression in healthy\n                    subjects","volume":"37","author":"U von Bardeleben","year":"1985","journal-title":"Life Sciences"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1677\/joe.0.1640197","article-title":"Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical\n                    alterations in aged rats","volume":"164","author":"M Hatzinger","year":"2000","journal-title":"J Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0893-133X(01)00351-7","article-title":"Vasopressin mediates the response of the combined dexamethasone\/CRH test in\n                    hyper-anxious rats: Implications for pathogenesis of affective disorders","volume":"26","author":"M E Keck","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/a-2372-3549:","article-title":"Precision psychiatry approach to treat depression and anxiety targeting the\n                    stress hormone system \u2013 V1b-antagonists as a case in point","author":"F Holsboer","year":"2024","journal-title":"Pharmacopsychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/187152706776359664","article-title":"The involvement of the vasopressin system in stress-related disorders","volume":"5","author":"R Landgraf","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1073\/pnas.092012099","article-title":"Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b\n                    receptor antagonist, SSR149415, suggest an innovative approach for the treatment\n                    of stress-related disorders","volume":"99","author":"G Griebel","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1023\/A:1020258104318","article-title":"High vs low anxiety-related behavior rats: An animal model of extremes in trait\n                    anxiety","volume":"32","author":"R Landgraf","year":"2002","journal-title":"Behav Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1523\/JNEUROSCI.15-06-04250.1995","article-title":"V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces\n                    vasopressin binding, social discrimination abilities, and anxiety-related\n                    behavior in rats","volume":"15","author":"R Landgraf","year":"1995","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.biopsych.2005.12.010","article-title":"Increased arginine vasopressin mRNA expression in the human hypothalamus in\n                    depression: A preliminary report","volume":"60","author":"G Meynen","year":"2006","journal-title":"Biol Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archpsyc.1996.01830020055007","article-title":"Increased number of vasopressin- and oxytocin-expressing neurons in the\n                    paraventricular nucleus of the hypothalamus in depression","volume":"53","author":"J S Purba","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/archpsyc.58.7.655","article-title":"Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in\n                    depression","volume":"58","author":"J N Zhou","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0893-133X(97)00144-9","article-title":"Hormonal response pattern in the combined DEX-CRH test is stable over time in\n                    subjects at high familial risk for affective disorders","volume":"18","author":"S Modell","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biopsych.2006.07.039","article-title":"Combined dexamethasone\/corticotropin releasing hormone test predicts treatment\n                    response in major depression-a potential biomarker?","volume":"62","author":"M Ising","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1176\/ajp.156.6.949","article-title":"Prediction of medium-term outcome by cortisol response to the combined\n                    dexamethasone-CRH test in patients with remitted depression","volume":"156","author":"A W Zobel","year":"1999","journal-title":"Am J Psychiatry"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archpsyc.64.10.1189","article-title":"Evidence of an association between the vasopressin V1b receptor gene (AVPR1B)\n                    and childhood-onset mood disorders","volume":"64","author":"E L Dempster","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.mp.4001420","article-title":"A major SNP haplotype of the arginine vasopressin 1B receptor protects against\n                    recurrent major depression","volume":"9","author":"D van West","year":"2004","journal-title":"Mol Psychiatry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpsychires.2008.05.002","article-title":"Clinical characteristics and treatment outcome in a representative sample of\n                    depressed inpatients \u2013 Findings from the Munich Antidepressant Response\n                    Signature (MARS) project","volume":"43","author":"J M Hennings","year":"2009","journal-title":"J Psychiatr Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-3956(01)00013-9","article-title":"Cortisol response in the combined dexamethasone\/CRH test as predictor of relapse\n                    in patients with remitted depression. A prospective study","volume":"35","author":"A W Zobel","year":"2001","journal-title":"J Psychiatr Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human\n                    tissues","volume":"369","author":"GTEx-Consortium","year":"2020","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1192\/bjp.141.1.45","article-title":"A comparison of depression rating scales","volume":"141","author":"N P Kearns","year":"1982","journal-title":"Br J Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jad.2013.04.028","article-title":"Severity classification on the Hamilton Depression Rating Scale","volume":"150","author":"M Zimmerman","year":"2013","journal-title":"J Affect Disord"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: The reference human genome annotation for The ENCODE Project","volume":"22","author":"J Harrow","year":"2012","journal-title":"Genome Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00213-002-1356-z","article-title":"Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed\n                    patients by mirtazapine","volume":"166","author":"C Sch\u00fcle","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.psyneuen.2013.10.008","article-title":"Impact on cortisol and antidepressant efficacy of quetiapine and escitalopram in\n                    depression","volume":"39","author":"N Sarubin","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1038\/sj.npp.1300280","article-title":"Pharmacological and nonpharmacological factors influencing\n                    hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed\n                    psychiatric in-patients, measured by the Dex-CRH test","volume":"28","author":"H E Kunzel","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nrd3702","article-title":"Neuropeptide receptor ligands as drugs for psychiatric diseases: The end of the\n                    beginning?","volume":"11","author":"G Griebel","year":"2012","journal-title":"Nat Rev Drug Discov"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2508-5834.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:50:04Z","timestamp":1764305404000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2508-5834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":36,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,4,30]]},"published-print":{"date-parts":[[2025,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2508-5834","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"type":"print","value":"0176-3679"},{"type":"electronic","value":"1439-0795"}],"subject":[],"published":{"date-parts":[[2025,1,29]]}}}