{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:24:14Z","timestamp":1764905054076,"version":"3.41.2"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The factors affecting the prolonged air leak (PAL) and expansion failure in the lung in patients undergoing resection for lung malignancy were analyzed. In this context, the value of the percentage of low attenuation area (LAA%) measured on preoperative quantitative chest computed tomography (Q-CT) in predicting the development of postoperative PAL and the expansion time of the remaining lung (ET) in patients undergoing resection for lung malignancy was investigated.<\/jats:p><jats:p>The data of 202 cases who underwent lung resection between July 2020 and December 2022 were analyzed. The factors affecting the development of PAL and ET were investigated using univariate and multivariate analyses. The cut-off value for LAA% was determined and its relationship with postoperative results was examined.<\/jats:p><jats:p>In univariate analyses, for PAL, age (p\u2009=\u20090.022), presence of chronic obstructive pulmonary disease (COPD; p\u2009&lt;\u20090.001), body mass index (BMI; p\u2009=\u20090.006), FEV1 (p\u2009=\u20090.020), FEV1\/FVC (p\u2009&lt;\u20090.001), LAA% (p\u2009=\u20090.008), diagnosis (p\u2009=\u20090.007), and surgical procedure (p\u2009&lt;\u20090.001); for ET, diagnosis (p\u2009&lt;\u20090.001) and surgical procedure (p\u2009=\u20090.001) were significant factors. A negative correlation between ET and BMI and FEV1\/FVC (p\u2009&lt;\u20090.01) and a positive correlation (p\u2009&lt;\u20090.05) was detected with LAA%. The cut-off value for LAA% was calculated as 1.065. Multivariate analyses showed that the probability of developing PAL, increased 3.17-, 7.68-, and 3.08-fold in patients with COPD, lobectomy, and those above the cut-off value for LAA%, respectively (p\u2009=\u20090.045, p\u2009&lt;\u20090.001, and p\u2009=\u20090.011). In addition, FEV1\/FVC (p\u2009=\u20090.027), BMI (p\u2009=\u20090.016), and surgical procedure (p\u2009=\u20090.001) were shown to be independent factors affecting ET.<\/jats:p><jats:p>Our study revealed the factors affecting PAL and expansion failure in the lung. Within this scope, it was concluded that preoperative Q-CT may have an important role in predicting the development of PAL and ET in the postoperative period and that LAA% measurement is an effective, objective, and practical method for taking precautions against possible complications.<\/jats:p>","DOI":"10.1055\/a-2508-6067","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T19:21:08Z","timestamp":1737487268000},"page":"418-426","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Factors Affecting Prolonged Air Leak and Expansion Failure in the Lung after Resection in Patients with Pulmonary Malignancy and Predictive Value of Preoperative Quantitative Chest Computed Tomography"],"prefix":"10.1055","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-4941","authenticated-orcid":false,"given":"Gizem Kececi","family":"Ozgur","sequence":"additional","affiliation":[{"name":"Y\u00fcksekova State Hospital, Thoracic Surgery Clinic, Hakkari, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-071X","authenticated-orcid":false,"given":"Hasan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Ministry of Health Mardin Education and Research Hospital, Thoracic Surgery Clinic, Mardin, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-0996","authenticated-orcid":false,"given":"Alpaslan","family":"Cakan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ege University Faculty of Medicine, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-6635","authenticated-orcid":false,"given":"Kevser","family":"Durgun","sequence":"additional","affiliation":[{"name":"Ministry of Health Bornova District Health Directorate, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8854-953X","authenticated-orcid":false,"given":"Ayse Gul","family":"Ergonul","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ege University Faculty of Medicine, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-9469","authenticated-orcid":false,"given":"Tevfik Ilker","family":"Akcam","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ege University Faculty of Medicine, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-1764","authenticated-orcid":false,"given":"Ali","family":"\u00d6zdil","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ege University Faculty of Medicine, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-9474","authenticated-orcid":false,"given":"Selen","family":"Bayraktaroglu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ege University Faculty of Medicine, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-0514","authenticated-orcid":false,"given":"Kutsal","family":"Turhan","sequence":"additional","affiliation":[{"name":"Ac\u0131badem University Kent Hospital, Thoracic Surgery Clinic, Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-793X","authenticated-orcid":false,"given":"Ufuk","family":"Cagirici","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ege University Faculty of Medicine, Izmir, 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Gull\u00f3n","year":"2011","journal-title":"Lung Cancer"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1183\/09031936.01.00255701","article-title":"Quantitative computed tomography assessment of lung structure and function in pulmonary emphysema","volume":"18","author":"A Madani","year":"2001","journal-title":"Eur Respir J"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1007\/s00330-022-08540-w","article-title":"CT-defined visual emphysema in smokers with normal spirometry: association with prolonged air leak and other respiratory complications after lobectomy for lung cancer","volume":"32","author":"T Yun","year":"2022","journal-title":"Eur Radiol"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00005382-198603000-00010","article-title":"CT in the qualitative assessment of emphysema","volume":"1","author":"C J Bergin","year":"1986","journal-title":"J Thorac Imaging"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1148\/radiol.212904","article-title":"Association between chest CT\u2013defined emphysema and lung cancer: a systematic review and meta-analysis","volume":"304","author":"X Yang","year":"2022","journal-title":"Radiology"},{"issue":"03","key":"ref8","first-page":"271","article-title":"The anticipation and management of air leaks and residual spaces post lung resection","volume":"6","author":"M R Mueller","year":"2014","journal-title":"J Thorac Dis"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"878","DOI":"10.21037\/jtd-22-736","article-title":"Intraoperative prevention and conservative management of postoperative prolonged air leak after lung resection: a systematic review","volume":"15","author":"V Aprile","year":"2023","journal-title":"J Thorac 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and terminology","volume":"99","author":"F G Fernandez","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"ezac211","DOI":"10.1093\/ejcts\/ezac211","article-title":"A Delphi Consensus report from the \u201cProlonged Air Leak: A Survey\u201d study group on prevention and management of postoperative air leaks after minimally invasive anatomical resections","volume":"62","author":"F Zaraca","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.athoracsur.2009.09.020","article-title":"Management of alveolar air leaks after pulmonary resection","volume":"89","author":"S Singhal","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/ejcts\/ezt452","article-title":"National perioperative outcomes of pulmonary lobectomy for cancer: the 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