{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:41:26Z","timestamp":1772664086065,"version":"3.50.1"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autologous platelet-rich plasma (PRP) has gained popularity for hair restoration due to its effectiveness and safety. PRP could be administered through direct local injections to the scalp or applied topically with the aid of microneedling therapy. This systematic review aims to elaborate on the effectiveness of PRP administered with syringe injection and topical PRP with microneedling combination for the treatment of androgenetic alopecia (AGA). A literature search was employed through PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, and Scopus. The database was searched using terms and keywords: \u201cplatelet-rich plasma\u201d and \u201cmicroneedling\u201d and \u201candrogenetic alopecia.\u201d Inclusion criteria are human study, patients with AGA, studies that compare PRP with syringe injection and the combination of PRP and microneedling. Exclusion criteria are animal study, review, case reports, or studies on other form of alopecia.<\/jats:p><jats:p>A total of 108 articles found in the database. Title and abstract screening yield 12 articles. After full-text reading three articles were included in the review. A combination of PRP and microneedling appears to yield more superior results than direct syringe injection. Topical PRP and microneedling potentially give better results on AGA cases. Further high-quality studies with uniform protocol are needed to confirm these findings.<\/jats:p><jats:p>\n          Level of Evidence\u2003I.<\/jats:p>","DOI":"10.1055\/a-2510-5517","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:22:31Z","timestamp":1741738951000},"page":"059-068","source":"Crossref","is-referenced-by-count":1,"title":["Local Injection versus Topical Microneedling of Platelet-Rich Plasma for Androgenetic Alopecia: A Systematic Review"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5224-2146","authenticated-orcid":false,"given":"Johannes Albert","family":"Biben","sequence":"additional","affiliation":[{"name":"Hayandra Clinic, Hayandra Peduli Foundation, Central Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7570-4984","authenticated-orcid":false,"given":"Ryan","family":"Reinhart","sequence":"additional","affiliation":[{"name":"Tobelo Regional General Hospital, Jl.Landbouw, North Halmahera, North Maluku, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-3892","authenticated-orcid":false,"given":"Karina","family":"Karina","sequence":"additional","affiliation":[{"name":"Hayandra Clinic, Hayandra Peduli Foundation, Central Jakarta, Indonesia"},{"name":"HayandraLab., Yayasan Hayandra Peduli, Central Jakarta, Indonesia"},{"name":"Faculty of Medicine, Pembangunan Nasional University, Veteran Jakarta, Indonesia"},{"name":"Stem Cell Study Center, Pembangunan Nasional University Veteran, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9024-0843","authenticated-orcid":false,"given":"Kuswan Ambar","family":"Pamungkas","sequence":"additional","affiliation":[{"name":"Hayandra Clinic, Hayandra Peduli Foundation, Central Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-0634","authenticated-orcid":false,"given":"Krista","family":"Ekaputri","sequence":"additional","affiliation":[{"name":"Hayandra Clinic, Hayandra Peduli Foundation, Central Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1381-9299","authenticated-orcid":false,"given":"Patricia Marcellina","family":"Sadikin","sequence":"additional","affiliation":[{"name":"Hayandra Clinic, Hayandra Peduli Foundation, Central Jakarta, 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