{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:38:03Z","timestamp":1784907483457,"version":"3.55.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"name":"German Federal Ministry of Education and Research","award":["BMBF 01EO1003"],"award-info":[{"award-number":["BMBF 01EO1003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thrombocytopenia is one of the most common manifestations of the antiphospholipid syndrome (APS). However, its causes are still poorly defined. We have shown recently that antiphospholipid antibodies (aPL) directed against \u03b22-glycoprotein I (\u03b22GPI) of the IgG isotype induced platelet activation and aggregation while aPL directed against cardiolipin and anti-\u03b22GPI IgM had no effect. Since platelet activation by anti-\u03b22GPI might lead to platelet consumption and lower platelet count or overt thrombocytopenia, we analyzed the association of aPL with platelet count.<\/jats:p>\n                  <jats:p>Data of consecutive patients with test orders for anticardiolipin IgG\/IgM and anti-\u03b22GPI IgG\/IgM and full blood count in our laboratory from August 2015 to April 2019 were analyzed.<\/jats:p>\n                  <jats:p>We identified 2,815 individual patients (mean age 45.7 years; 71.1% women) with complete data on aPL and platelet count, of which 445 individuals (mean age 41.0 years; 75.3% women) showed increased aPL titers. Patients with anti-\u03b22GPI of the IgG isotype had significantly lower platelet count (220\u2009\u00b1\u200984 versus 264\u2009\u00b1\u200990 G\/L, p\u2009&lt;\u20090.0001) and higher frequency of thrombocytopenia (platelet count &lt;100 G\/L; 12.2% versus 2.4%, p\u2009&lt;\u20090.005) than patients negative for all four aPL. These differences could not be explained by comorbidities or medications. Neither anticardiolipin IgG nor aPL of the IgM isotype was associated with lower platelet count or thrombocytopenia.<\/jats:p>\n                  <jats:p>The exclusive association of anti-\u03b22GPI IgG aPL with low platelet count coincides with its unique ability to activate platelets and induce aggregation in vitro. This supports the hypothesis that anti-\u03b22GPI IgG aPL may induce thrombocytopenia by chronic platelet consumption in vivo.<\/jats:p>","DOI":"10.1055\/a-2510-6147","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T19:10:36Z","timestamp":1736277036000},"page":"1249-1255","source":"Crossref","is-referenced-by-count":4,"title":["Association of Specific Antiphospholipid Antibodies to Platelet Count and Thrombocytopenia"],"prefix":"10.1055","volume":"125","author":[{"given":"Katharina","family":"Griem","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Falter","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hollerbach","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-4035","authenticated-orcid":false,"given":"Kerstin","family":"Jurk","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahim","family":"Aboulmaouahib","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Weinmann-Menke","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"M\u00fcller-Calleja","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany"},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Lackner","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1136\/annrheumdis-2013-204838","article-title":"Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a 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