{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:11:23Z","timestamp":1773324683752,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>\u2002 Analyse des diagnostischen Nutzens des MTA-Scores im Kontext von Patientenalter, zerebraler Mikroangiopathie und automatisierten Analyseverfahren.<\/jats:p>\n                  <jats:p>\u2002 retrospektive Analyse von Patienten mit subjektiver kognitiver St\u00f6rung (SCD), amnestischem MCI (aMCI), Alzheimer-Demenz (AD) und gemischter Demenz (MD) aus einem universit\u00e4ren Demenzzentrum, die sich von 02\/2016 bis 12\/2020 erstmals zur Demenzdiagnostik inklusive einer kraniellen MRT vorgestellt hatten. Eingeschlossen wurden Patienten, bei denen eine 3D-T1-Sequenz und eine FLAIR-Sequenz f\u00fcr die automatisierte Hirnvolumetrie und L\u00e4sionsdetektion- und -volumetrie mittels einer CE-zertifizierten Software zur Verf\u00fcgung stand. Es erfolgte die Erhebung des MTA-Scores, des Fazekas-Scores, der automatisiert-volumetrisch erfassten Hippocampus- und Temporallappen-Perzentilen sowie des Gesamtl\u00e4sionsvolumens der wei\u00dfen Substanz.<\/jats:p>\n                  <jats:p>\u2002 Im Beobachtungszeitraum von 02\/2018 bis 12\/2020 wurden 242 Patienten (100 m\u00e4nnlich, 142 weiblich, Durchschnittsalter 74,7\u00b19,9 Jahre) mit SCD (n=20), aMCI (n=110), AD (n=62) und MD (n=50) analysiert. Der MTA-Score korrelierte stark mit dem Patientenalter (\u03c1=0,545; p&lt;0,001), was insbesondere in der aMCI- und der AD-Gruppe beobachtbar war. Dabei unterschied sich der MTA-Score ausschlie\u00dflich zwischen Prodromal- und Demenzstadien signifikant (aMCI vs. AD: p=0,005), w\u00e4hrend die Hippocampus-Perzentilen auch tendenzielle Unterschiede zwischen SCD und aMCI detektierten. MTA-Score und Hippocampus-Perzentilen korrelierten insgesamt signifikant (\u03c1=\u22120,385; p&lt;0,001), was in den Einzelgruppen nur bei aMCI- und AD-Patienten nachweisbar war. Der MTA-Score und auch die Hippocampus-Perzentilen korrelierten mit den Temporallappen-Perzentilen. Insgesamt korrelierten MTA- und Fazekas-Score mittelstark miteinander (\u03c1=0,451; p&lt;0,001), in der Auswertung der einzelnen Patientengruppen nur in der aMCI- und der AD-Gruppe. Korrelationen zwischen Hippocampus-Perzentilen und Gesamtl\u00e4sionsvolumina der wei\u00dfen Substanz wurden weder insgesamt, noch innerhalb der diagnostischen Gruppen beobachtet.<\/jats:p>\n                  <jats:p>\u2002 Bei der Interpretation des MTA-Scores muss das Patientenalter in Form alterskorrigierter Referenzwerte ber\u00fccksichtigt werden. Insbesondere in der Fr\u00fchdiagnostik zeigen automatisierte volumetrische Verfahren m\u00f6glicherweise Vorteile in der Diagnostik subjektiver und leichter kognitiver St\u00f6rungen, wobei der MTA-Score gute Korrelationen mit volumetrisch erfassten Hippocampus-Perzentilen zeigt. Ob die hippocampale Atrophie durch vaskul\u00e4r bedingte Denervierungsprozesse im Rahmen einer zerebralen Mikroangiopathie moduliert wird, bedarf weiterer Untersuchungen.<\/jats:p>","DOI":"10.1055\/a-2512-7931","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T18:42:31Z","timestamp":1738176151000},"page":"95-100","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostischer Nutzen des MTA-Scores in Abh\u00e4ngigkeit von Patientenalter und zerebraler Mikroangiopathie sowie in Zeiten automatisierter Analyseverfahren"],"prefix":"10.1055","volume":"94","author":[{"given":"Pauline Klara","family":"Sander","sequence":"additional","affiliation":[{"name":"Psychiatry, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrin","family":"Sauer","sequence":"additional","affiliation":[{"name":"Psychiatry, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Grey","sequence":"additional","affiliation":[{"name":"Neuroradiology, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Krukowski","sequence":"additional","affiliation":[{"name":"Neuroradiology, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Linn","sequence":"additional","affiliation":[{"name":"Neuroradiology, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz D.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Neurology, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-5180","authenticated-orcid":false,"given":"Robert","family":"Haussmann","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie, University Hospital Carl Gustav Carus, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"G B Frisoni","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1136\/jnnp.55.10.967","article-title":"Atrophy of medial temporal lobes on MRI in \u201cprobable\u201d Alzheimer\u02bcs disease and normal ageing: diagnostic value and neuropsychological correlates","volume":"55","author":"P Scheltens","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s12975-020-00847-4","article-title":"Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment","volume":"12","author":"FC C Wong","year":"2021","journal-title":"Transl Stroke Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/hipo.23039","article-title":"Memory decline in elderly with cerebral small vessel disease explained by temporal interactions between white matter hyperintensities and hippocampal atrophy","volume":"29","author":"EM C van Leijsen","year":"2019","journal-title":"Hippocampus"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"760360","DOI":"10.3389\/fnhum.2022.760360","article-title":"The Correlation Between White Matter Hyperintensity Burden and Regional Brain Volumetry in Patients With Alzheimer\u02bcs Disease","volume":"16","author":"Z Cao","year":"2022","journal-title":"Front Hum Neurosci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1007\/s00330-016-4726-3","article-title":"Practical use of visual medial temporal lobe atrophy cut-off scores in Alzheimer\u02bcs disease: Validation in a large memory clinic population","volume":"27","author":"J J Claus","year":"2017","journal-title":"Eur Radiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12883-021-02325-2","article-title":"Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population","volume":"21","author":"A Molinder","year":"2021","journal-title":"BMC Neurol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.eurpsy.2008.02.004","article-title":"Subjective Memory Impairment. 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