{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T22:50:14Z","timestamp":1761259814877,"version":"build-2065373602"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["#188591"],"award-info":[{"award-number":["#188591"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To determine whether the nonfunctional liver volume (NFLV) is an indicator of chronic liver disease (CLD).<\/jats:p>\n                  <jats:p>Multiparametric 3T abdominal MRI examinations enhanced with gadobenate dimeglumine of 51 patients were included in the study and divided into two groups: patients with (n=20) and without (n=31) CLD. Pre- and postcontrast T1 relaxation times of the liver and aorta were measured in the T1 mapping sequences. Total and segmental liver volumes (Lvol) were determined using a convolutional neuronal network. The functional liver fraction (FLF) defined as [(1\/T1liver postcontrast \u2212 1\/T1liver precontrast) \u00f7 (1\/T1blood pool postcontrast \u2212 1\/T1blood pool precontrast)] \u00d7 (1 \u2212 hematocrit) and the nonfunctional liver volume (NFLV) defined as (1 \u2212 FLF) \u00d7 Lvol were calculated for the whole liver, segments I\u2013III, and IV\u2013VIII. Volumes, FLF, and NFLV were compared between the groups using the Mann-Whitney U test and receiver operation characteristics (ROC) analysis.<\/jats:p>\n                  <jats:p>Volumes were significantly higher in patients with CLD than without CLD for the whole liver (p&lt;.01), segments I\u2013III (p&lt;.001), and segments IV\u2013VIII (p&lt;.01). No significant difference was found regarding FLF (p=.20\u201331). NFLV of the whole liver (p&lt;.01), segments I\u2013III (p&lt;.001), and IV\u2013VIII (p&lt;.01) were significantly increased in patients with CLD. The highest AUCs were observed for Lvol (AUC=.80; p&lt;.001) and NFLV (AUC=.78; p&lt;.001), both in segments I\u2013III. The optimal NFLV cutoff values for CLD were 745 ml for the whole liver (77 % sensitivity; 75% specificity), 174 ml for segments I\u2013III (85% sensitivity; 70% specificity), and 573 ml for segments IV\u2013VIII (77% sensitivity; 75% specificity).<\/jats:p>\n                  <jats:p>MRI-derived nonfunctional liver volume (NFLV) is helpful for early detection of imaging changes in CLD. NFLV is highly associated with CLD, notably when measured in the liver segments I\u2013III.<\/jats:p>","DOI":"10.1055\/a-2514-4596","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T20:02:44Z","timestamp":1741636964000},"page":"1300-1310","source":"Crossref","is-referenced-by-count":0,"title":["Association of MRI-derived Segmental Nonfunctional Liver Volume and Chronic Liver Disease"],"prefix":"10.1055","volume":"197","author":[{"given":"Marie","family":"Ardoino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Zbinden","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"},{"name":"ARTOG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-0184","authenticated-orcid":false,"given":"Jeremias B.","family":"Klaus","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"},{"name":"Institute of Forensic Medicine, University of Bern, Bern, Switzerland"},{"name":"Radiologie, Dr. Kurz R\u00f6ntgeninstitut AG, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Arthur","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Catucci","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"},{"name":"Graduate School for Health Sciences, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Br\u00f6nnimann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"},{"name":"Radiology and Nuclear Medicine (RUN), Luzerner Kantonsspital Zentrumsspital, Luzern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes T.","family":"Heverhagen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Christe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"},{"name":"Liver Elastography Center, Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland"},{"name":"Radiology and Nuclear Medicine (RUN), Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-9968","authenticated-orcid":false,"given":"Verena C.","family":"Obmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital Bern, Bern, Switzerland"},{"name":"Liver Elastography Center, Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland"},{"name":"Department of Radiology, Zuger Kantonsspital, Baar, 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Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2514-4596.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T22:43:17Z","timestamp":1761259397000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2514-4596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,10,23]]},"published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2514-4596","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"type":"print","value":"1438-9029"},{"type":"electronic","value":"1438-9010"}],"subject":[],"published":{"date-parts":[[2025,3,10]]}}}