{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:34:12Z","timestamp":1755797652335,"version":"3.44.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The impact of type 1 DM (T1DM) on thromboembolism in pregnancy is uncertain. We hypothesized that T1DM is associated with higher rates of thrombotic events during pregnancy and the postpartum period.<\/jats:p><jats:p>This is a retrospective cohort study utilizing the National Inpatient Sample database from HCUP\/AHRQ for 2017\u20132019. Pregnant and postpartum patients with a history of T1DM were compared to those without. The primary outcome was a composite diagnosis of any thrombotic disease (pulmonary embolism [PE], deep vein thrombosis [DVT], cerebral vascular thrombosis [CVT], or other thromboses). Secondary outcomes were the diagnosis of each individual type of thromboembolic event. Groups were compared via student's test, chi-squared, and logistic regression analyses, controlling for confounders including age, race, obesity, tobacco use, cHTN, asthma, anemia, and cesarean section.<\/jats:p><jats:p>A total of 2,361,711 subjects met the criteria. Patients with T1DM encompassed 0.4% of subjects (n\u2009=\u20099,983). T1DM subjects were more likely to be younger, non-Hispanic white, obese, tobacco users, chronic hypertensive, asthmatic, and have a history of cesarean (all p\u2009&lt;\u20090.001). They were less likely to be in the top income quartile. Thromboembolic events occurred more frequently in those with T1DM (0.45% vs. 0.20%, p\u2009&lt;\u20090.001). DVT was the most common event (0.25%). After controlling for confounders, T1DM remained independently associated with any thromboembolic event in pregnancy (adjusted odds ratio [aOR]\u2009=\u20092.19, 95% confidence interval [CI]: 1.49\u20133.23), PE (aOR\u2009=\u20093.59, 95% CI: 1.65\u20137.82), and DVT (aOR\u2009=\u20092.43, 95% CI: 1.43\u20134.14).<\/jats:p><jats:p>T1DM is associated with an increased risk of thromboembolic events in pregnancy.<\/jats:p>","DOI":"10.1055\/a-2515-2602","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T19:36:16Z","timestamp":1736883376000},"page":"1588-1593","source":"Crossref","is-referenced-by-count":0,"title":["Type 1 Diabetes Mellitus and Thromboembolism in Pregnancy"],"prefix":"10.1055","volume":"42","author":[{"given":"Jacob","family":"Thomas","sequence":"additional","affiliation":[{"name":"Ascension St. Alexius Department of Obstetrics and Gynecology, Hoffman Estates, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Brewerton","sequence":"additional","affiliation":[{"name":"Ascension St. Alexius Department of Obstetrics and Gynecology, Hoffman Estates, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calla","family":"Holmgren","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Advocate Aurora Health, St Oak Lawn, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Advocate Aurora Health, St Oak Lawn, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"issue":"03","key":"ref1","first-page":"92","article-title":"Type 1 diabetes mellitus and pregnancy","volume":"3","author":"R Vargas","year":"2010","journal-title":"Rev Obstet 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