{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:31:51Z","timestamp":1785515511749,"version":"3.56.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate the frequency of adverse maternal and neonatal outcomes associated with maternal obesity in a Hispanic population. We hypothesized that obesity confers a dose-dependent risk associated with these outcomes.<\/jats:p><jats:p>This was a retrospective cohort study of singleton pregnancies delivered between 24 and 42 weeks gestation at an urban county hospital between 2013 and 2021. Body mass index (BMI) at the first prenatal visit was used as a proxy for prepregnancy weight. Patients were excluded if their first-trimester BMI was not available. Trends in adverse outcomes across increasing obesity classes were assessed.<\/jats:p><jats:p>During the study period, 58,497 patients delivered a singleton infant, of which 12,365 (21.1%), 5,429 (9.3%), and 3,482 (6.0%) were in class I, II, and III obesity, respectively. Compared with nonobese patients, obese patients were more likely to be younger and nulliparous with a higher incidence of hypertension and pregestational diabetes. Higher BMI was associated with a significant dose-dependent increase in cesarean delivery (27% for nonobese, 34% for class I, 39% for class II, and 46% for class III obesity); severe preeclampsia (8% in nonobese and 19% for class III obesity); and gestational diabetes (5% in nonobese and 15% in class III obesity). There were significant trends in increasing morbidity for infants born to patients with correspondingly higher obesity classes. Some of these adverse outcomes included respiratory distress syndrome, neonatal intensive care unit admission, fetal anomalies, and sepsis (all p\u2009&lt;\u20090.001).<\/jats:p><jats:p>Increasing body mass index is associated with a significant dose-dependent increase in multiple adverse perinatal outcomes in a Hispanic population. Associated adverse maternal outcomes include severe preeclampsia, gestational diabetes, and cesarean delivery. Infants born to patients with correspondingly higher BMI class have significantly increased associated morbidity. Often, only higher BMI classes are significantly associated with these adverse outcomes.<\/jats:p>","DOI":"10.1055\/a-2515-2673","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T19:36:16Z","timestamp":1736883376000},"page":"1594-1602","source":"Crossref","is-referenced-by-count":4,"title":["The Dose-Dependent Effect of Obesity on Adverse Maternal and Neonatal Outcomes in a Hispanic Population"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9656-7893","authenticated-orcid":false,"given":"Sara I.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise A.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-3229","authenticated-orcid":false,"given":"Jessica E.","family":"Pruszynski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Gary","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/pd.5784","article-title":"Perinatal exposure to maternal obesity: lasting cardiometabolic impact on offspring","volume":"40","author":"S Kislal","year":"2020","journal-title":"Prenat Diagn"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2015.04.006","article-title":"Inflammation in maternal obesity and gestational diabetes mellitus","volume":"36","author":"P Pantham","year":"2015","journal-title":"Placenta"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1055\/s-0032-1328874","article-title":"Obesity, pregnancy complications, and birth outcomes","volume":"30","author":"N E Marshall","year":"2012","journal-title":"Semin Reprod Med"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S1701-2163(15)30879-3","article-title":"Maternal and perinatal outcomes of extreme obesity in pregnancy","volume":"35","author":"J M Crane","year":"2013","journal-title":"J Obstet Gynaecol Can"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"100420","DOI":"10.1016\/j.ajogmf.2021.100420","article-title":"Severe maternal morbidity and mortality during delivery hospitalization of class I, II, III, and super obese women","volume":"3","author":"M H Platner","year":"2021","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"25","key":"ref6","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1080\/14767058.2021.1988563","article-title":"Prevalence of maternal obesity at delivery and association with maternal and neonatal outcomes","volume":"35","author":"C Castaneda","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1097\/AOG.0000000000002046","article-title":"Methods for estimating the due date. 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