{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:15:16Z","timestamp":1743480916688,"version":"3.40.3"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Eleutherococcus senticosus (ES) exerts various pharmacological effects, including renoprotection in a rat model of renal ischemia-reperfusion injury. However, the mechanisms of these effects remain unclear. Therefore, we investigated the effects and mechanisms of ES on aristolochic acid (AA)-induced acute kidney injury in mice. The experimental mice were divided into the control group, the model group (AA-induced acute kidney injury model), the model + ES group (Eleutherococcus senticosus boiled-free granules treated by gavage for two weeks), the model + fasudil group (fasudil administered intraperitoneally for three days), and the model + ES + fasudil group. After AA intervention in normal mice, the expression of ASC and NLRP3 and the levels of IL-1\u03b2, IL-18, and TNF-\u03b1 were significantly elevated in mouse renal tissues (P\u2009&lt;\u20090.05). However, AA-induced renal dysfunction was ameliorated by both ES and fasudil, which was confirmed by the decrease\n          in serum creatinine and blood urea nitrogen levels, as well as by renal histopathological abnormalities such as renal tubule dilation and tubular formation. In addition, the inflammatory response of AA-induced renal inflammation was inhibited by both ES and fasudil, and the expression of ASC and NLRP3 and the levels of IL-1\u03b2, IL-18, and TNF-\u03b1 were significantly higher in mouse renal tissues after the treatment of either ES or fasudil (P\u2009&lt;\u20090.05). ES may be a potential treatment agent for aristolochic-acid-triggered nephropathy, with inhibition of the NLRP3\/IL-1\u03b2 as one plausible underlying mechanism.<\/jats:p>","DOI":"10.1055\/a-2517-9234","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T23:58:37Z","timestamp":1737763117000},"page":"189-196","source":"Crossref","is-referenced-by-count":0,"title":["Eleutherococcus senticosus Alleviates Aristolochic-Acid-Induced Acute Kidney Damage by Inhibiting the NLRP3\/IL-1\u03b2 Signaling Pathway in Mice"],"prefix":"10.1055","volume":"91","author":[{"given":"Jian-hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-zhu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, Shanghai University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-dan","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-meng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-4848","authenticated-orcid":false,"given":"Jie-wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3390\/ijms18020297","article-title":"An integrated view of aristolochic acid nephropathy: Update of the literature","volume":"18","author":"I Jadot","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e26510","DOI":"10.1097\/MD.0000000000026510","article-title":"Aristolochic acid nephropathy: A scientometric analysis of literature published from 1971 to 2019","volume":"100","author":"H Ji","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1016\/j.freeradbiomed.2010.03.021","article-title":"Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways","volume":"48","author":"E Katsoulieris","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1113\/EP085333","article-title":"Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: An old friend with new assets","volume":"101","author":"A E Decleves","year":"2016","journal-title":"Exp Physiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.7150\/ijbs.69618","article-title":"Dissection of targeting molecular mechanisms of aristolochic acid-induced nephrotoxicity via a combined deconvolution strategy of chemoproteomics and 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Baudoux","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"12432","DOI":"10.3390\/ijms222212432","article-title":"Aristolochic acid induces renal fibrosis and senescence in mice","volume":"22","author":"S Urate","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5414\/cn107414","article-title":"Clinical and pathological spectrums of aristolochic acid nephropathy","volume":"78","author":"D Chen","year":"2012","journal-title":"Clin Nephrol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/08860220601095918","article-title":"Hospital-acquired and community-acquired acute renal failure in hospitalized Chinese: A ten-year review","volume":"29","author":"Y Wang","year":"2007","journal-title":"Ren Fail"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/jcpt.12789","article-title":"Recognition of the 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Wang","year":"2022","journal-title":"Theranostics"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"17479","DOI":"10.18632\/oncotarget.8243","article-title":"Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury","volume":"7","author":"W Ding","year":"2016","journal-title":"Oncotarget"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/biom10010011","article-title":"Protective effects of melatonin against aristolochic acid-induced nephropathy in mice","volume":"10","author":"J Y Kim","year":"2019","journal-title":"Biomolecules"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"116152","DOI":"10.1016\/j.jep.2023.116152","article-title":"Botany, traditional usages, phytochemistry, pharmaceutical analysis, and pharmacology of Eleutherococcus nodiflorus (Dunn) S.Y.Hu: A systematic review","volume":"306","author":"X Li","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"113586","DOI":"10.1016\/j.jep.2020.113586","article-title":"A review of Acanthopanax senticosus (Rupr and Maxim.) harms: From ethnopharmacological use to modern application","volume":"268","author":"A Jia","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref33","first-page":"105","article-title":"[Effect of Acanthopanax senticosus injection on plasma and urinary endothelin in early stage of diabetic nephropathy]","volume":"21","author":"H X Ni","year":"2001","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"681","DOI":"10.7501\/j.issn.1674-5515.2022.04.002","article-title":"Effect of Ciwujia Injection reduces renal ischemia-reperfusion injury in rats by regulating Nrf2\/HO-1 pathway","volume":"37","author":"L Qiang","year":"2022","journal-title":"Drugs & 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Wang","year":"2019","journal-title":"Front Immunol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"905547","DOI":"10.3389\/fphar.2022.905547","article-title":"Assessment of fasudil on contrast-associated acute kidney injury using multiparametric renal MRI","volume":"13","author":"B Wang","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.11855\/j.issn.0577-7402.2023.01.0027","article-title":"Effect of fasudil attenuates acute lung injury induced by lipopolysaccharide and its mechanism","volume":"48","author":"Y Chao-Ying","year":"2023","journal-title":"Medical Journal of Chinese People\u02bcs Liberation Army"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3321\/j.issn:1003-9783.2003.05.010","article-title":"Pharmacokinetic studies of radix acanthopanacis senticosis suspension","volume":"14","author":"T Jing","year":"2003","journal-title":"Traditional Chinese Drug Research and Clinical Pharmacology"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 inflammasome and reactive oxygen species","volume":"36","author":"A Dominic","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"57003","DOI":"10.1289\/EHP7612","article-title":"The Kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL\/6 mice","volume":"129","author":"Y L Wang","year":"2021","journal-title":"Environ Health Perspect"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/s41419-020-02876-1","article-title":"Upregulation of miR-382 contributes to renal fibrosis secondary to aristolochic acid-induced kidney injury via PTEN signaling pathway","volume":"11","author":"X Wang","year":"2020","journal-title":"Cell Death 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