{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:58:36Z","timestamp":1791176316692,"version":"4.1.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There has been much debate about the appropriateness of over-the-counter\n                        (OTC) cough and common cold medications (CCM). The aim of this nationwide\n                        study was to analyse the incidence of CCM intoxications in the Czech\n                        paediatric population from 2014 to 2023.<\/jats:p>\n                  <jats:p>We performed a retrospective study on the incidence of CCM intoxications in\n                        the Czech paediatric population (ages 0\u201318 years) from 2014 to 2023.<\/jats:p>\n                  <jats:p>There were 7,056 cases of CCM intoxication in children, of which 6,406\n                        resulted from unintentional intoxication. No lethal doses were reported, but\n                        there were 1,769 documented toxic doses. Unintentional CCM intoxications\n                        represented 15.60% of all unintentional medication intoxication cases across\n                        all ages and medication types. Of the 6,406 unintentional intoxication\n                        cases, 5,465 (85.31%) were in children aged 0 to 6 years, including 1,564\n                        (24.41%) in children aged 0 to 2 years. Children aged 0 to 6 years had a\n                        significantly higher risk of CCM intoxication compared to those aged 7 to 18\n                        years (RR 9.5, p&lt;0.00001). The annual incidence of unintentional CCM\n                        intoxication was 69.26 per 100,000 children aged 0 to 6 years and 7.29 per\n                        100,000 children aged 7 to 18 years.<\/jats:p>\n                  <jats:p>Based on our data, we believe there is low awareness among parents and Czech\n                        paediatricians regarding the potential risks of CCM and the lack of proven\n                        efficacy of these medications.<\/jats:p>\n                  <jats:p>Our data may contribute to political discussions regarding the general\n                        prohibition of CCM use in children younger than six years.<\/jats:p>","DOI":"10.1055\/a-2518-5571","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T20:40:52Z","timestamp":1738960852000},"page":"261-264","source":"Crossref","is-referenced-by-count":2,"title":["High prevalence of cough and common cold medication intoxications in\n                    the Czech paediatric population"],"prefix":"10.1055","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-4020","authenticated-orcid":false,"given":"Patrik","family":"Konop\u00e1sek","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents, University hospital Kralovske\n                    Vinohrady, Praha, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Kot\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Toxicology Information Centre, First Faculty of Medicine, General\n                    University Hospital in Prague, Praha, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Peckov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Applied Mathematics and Information Technologies, Charles\n                    University Faculty of Science, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"David","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents, Charles University Third\n                    Faculty of Medicine, Praha, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00408-011-9319-y","article-title":"Therapeutic options for acute cough due to upper respiratory infections in\n                    children","volume":"190","author":"I M Paul","year":"2012","journal-title":"Lung"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e000137","DOI":"10.1136\/bmjresp-2016-000137","article-title":"Comprehensive evidence-based review on European antitussives","volume":"3","author":"A Morice","year":"2016","journal-title":"BMJ Open Respir Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e12467","DOI":"10.1002\/emp2.12467","article-title":"Use of antitussive medications in acute cough in young children","volume":"2","author":"SH F Lam","year":"2021","journal-title":"J Am Coll Emerg Physicians Open"},{"key":"ref5","first-page":"30","article-title":"Cough medicines for children- time for a reality check","volume":"48","author":"G Clark","year":"2023","journal-title":"Paediatr Respir Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e477","DOI":"10.17269\/CJPH.106.5148","article-title":"Mandatory labelling requirements and over-the-counter cough and cold medication\n                    use in early childhood","volume":"106","author":"J DeGroot","year":"2016","journal-title":"Can J Public Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2147\/PHMT.S468314","article-title":"Clinical Toxicology of OTC Cough and Cold Pediatric Medications: A Narrative\n                    Review","volume":"15","author":"A Diantini","year":"2024","journal-title":"Pediatric Health Med Ther"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.acap.2019.09.006","article-title":"Medication Errors From Over-the-Counter Cough and Cold Medications in\n                    Children","volume":"20","author":"G S Wang","year":"2020","journal-title":"Acad Pediatr"},{"key":"ref11","first-page":"CD001831","article-title":"Over-the-counter (OTC) medications for acute cough in children and adults in\n                    community settings","volume":"2014","author":"S M Smith","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1517\/14740330903496410","article-title":"Safety and efficacy of over-the-counter cough and cold medicines for use in\n                    children","volume":"9","author":"Z P Vassilev","year":"2010","journal-title":"Expert Opin Drug Saf"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1542\/peds.2013-2236","article-title":"Cough and cold medication adverse events after market withdrawal and labeling\n                    revision","volume":"132","author":"L M Hampton","year":"2013","journal-title":"Pediatrics"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2518-5571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:30:49Z","timestamp":1789684249000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2518-5571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":10,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,9,17]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2518-5571","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]}}}