{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:36:14Z","timestamp":1764308174735,"version":"3.46.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Placental mesenchymal dysplasia (PMD) is a rare disease with unclear etiology and\n                    peculiar placental findings (placentomegaly, abnormal chorionic vessels with\n                    thromboses, and grossly enlarged and often cystic-appearing stem villi).\n                    Songraphic findings are cystic changes, hypoechoic areas, placental enlargement,\n                    and dilated chorionic vessels.PMD can be associated with severe perinatal\n                    complications, e.g., intrauterine fetal demise, fetal growth restriction, and\n                    preterm delivery. Neonatal complications include Beckwith-Wiedemann Syndrome\n                    (BWS), hepatic tumors, and hematologic diseases, i.e., anemia and\n                    thrombocytopenia. However, in a minority of cases the mothers and children\n                    display no perinatal or postnatal findings. It is important to be aware of the\n                    entity because it can be mistaken for molar pregnancy (with a different clinical\n                    procedure) on routine ultrasound investigation. Maternal alpha-fetoprotein serum\n                    levels are often increased in the case of PMD.We report a case of PMD with\n                    typical entity-related findings on ultrasound investigation and striking\n                    pathological-anatomic findings such as massive placentomegaly and prominent\n                    thromboses of the tortuous chorionic vessels but without perinatal or postnatal\n                        complications.<\/jats:p>","DOI":"10.1055\/a-2519-5898","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T19:13:16Z","timestamp":1739905996000},"page":"208-211","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal dysplasia of the placenta: a rare entity and important\n                    differential diagnosis. Presentation of a case with\n                    placentomegaly"],"prefix":"10.1055","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-4555","authenticated-orcid":false,"given":"Henning","family":"Feist","sequence":"additional","affiliation":[{"name":"Pathologie, Diakonissenkrankenhaus Flensburg, Flensburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afram","family":"Daliapo","sequence":"additional","affiliation":[{"name":"Gyn\u00e4kologie und Geburtshilfe, Diakonissenkrankenhaus\n                    Flensburg, Flensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann-Christin","family":"S\u00f6nnichsen","sequence":"additional","affiliation":[{"name":"MVZ Abts\u2009&\u2009Partner M\u00f8lledam, Flensburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3390\/diagnostics12020293","article-title":"A challenging diagnosis: Placental mesenchymal dysplasia literature review and\n                    case report","volume":"12","author":"C Mehedintu","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-7494-5","volume-title":"Manual of Pathology of the Human Placenta. 2nd ed","author":"R N Baergen","year":"2011"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5858\/2007-131-131-PMD","article-title":"Placental mesenchymal dysplasia","volume":"131","author":"Z Parveen","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e33438","DOI":"10.1097\/MD.0000000000033438","article-title":"Misdiagnosis of placental mesenchymal dysplasia as pregnancy with hydatidiform\n                    mole: A case report and literature review","volume":"102","author":"P Tang","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejogrb.2019.01.014","article-title":"Placental mesenchymal dysplasia: An underdiagnosed placental pathology with\n                    various clinical outcomes","volume":"234","author":"C Guenot","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1111\/jog.14647","article-title":"Clinical manifestations of placental mesenchymal dysplasia in Japan: A\n                    multicenter case series","volume":"47","author":"C Kodera","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/uog.12359","article-title":"Systematic review of sonographic findings of placental mesenchymal dysplasia and\n                    subsequent pregnancy outcome","volume":"41","author":"U A Nayeri","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/OGX.0000000000000716","article-title":"Diagnosis and management of placental mesenchymal disease. A review of the\n                    literature","volume":"74","author":"R M Colpaert","year":"2019","journal-title":"Obstet Gynecol Surv"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/jog.12518","article-title":"Rare fetal complications associated with placental mesenchymal dysplasia: A\n                    report of two cases","volume":"41","author":"T Jimbo","year":"2015","journal-title":"J Obstet Gynaecol Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/ccr3.543","article-title":"Anemia in a neonate with placental mesenchymal dysplasia","volume":"4","author":"S Ishikawa","year":"2016","journal-title":"Clin Case Rep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam Placental Workshop\n                    Group Consensus Statement","volume":"140","author":"T Y Khong","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1136\/jmg.2005.033571","article-title":"Androgenetic\/biparental mosaicism causes placental mesenchymal dysplasia","volume":"43","author":"K A Kaiser-Rogers","year":"2006","journal-title":"J Med Genet"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1046\/j.1365-2559.2001.01256.x","article-title":"Pseudo-partial moles: Placental stem vessel hydrops and the association with\n                    Beckwith\u2013Wiedemann syndrome and complete moles","volume":"39","author":"F J Paradinas","year":"2001","journal-title":"Histopathology"},{"key":"ref14","first-page":"2419","article-title":"Early ultrasonographic diagnosis of placental mesenchymal dysplasia","volume":"18","author":"S Gerli","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"5563","DOI":"10.3390\/cancers14225563","article-title":"Placental mesenchymal dysplasia and Beckwith\u2013Wiedemann syndrome","volume":"14","author":"H Soejima","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/uog.9005","article-title":"Prenatal imaging and postnatal pathologic work-up in a case of fetal hepatic\n                    hamartoma and placental mesenchymal dysplasia","volume":"38","author":"B Ruhland","year":"2011","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2519-5898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:34:26Z","timestamp":1764308066000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2519-5898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":16,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,5,19]]},"published-print":{"date-parts":[[2025,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2519-5898","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}