{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:24:04Z","timestamp":1777976644810,"version":"3.51.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"crossref","award":["FKZ 13GW0286B"],"award-info":[{"award-number":["FKZ 13GW0286B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Multiple Sklerose ist eine Erkrankung des zentralen Nervensystems, die sich in der gest\u00f6rten Reizweiterleitung durch Sch\u00e4digung der Myelinschicht widerspiegelt. Neben den visuell evozierten Potenzialen sind es immer mehr auch die vestibul\u00e4r evozierten myogenen Potenziale (VEMPs), die zur Befundung mitbetrachtet werden. Aufgrund eines geringen Signal-Rausch-Abstandes werden \u00fcblicherweise einige 100 Reizantworten gemittelt, um aus diesen Kurven Amplitudenh\u00f6he und Latenzen zu bestimmen. Dieses Verfahren filtert jedoch Informationen aus der Messung heraus, welche weitere Erkenntnisse \u00fcber den Krankheitszustand liefern k\u00f6nnten.<\/jats:p><jats:p>16 junge Patienten mit MS und einem EDSS-Score von 1,4\u00b10,6 wurden mit 92 gesunden Probanden gleichen Alters verglichen. Als Parameter wurden aus den taktil ausgel\u00f6sten oVEMPs die n10-Amplitude, die n10-Latenz, das AR sowie 5 neue Parameter aus der neuen Analysemethode herangezogen.<\/jats:p><jats:p>Die n10-Amplitude gesamt sowie die n10-Amplitude links waren grenzwertig signifikant unterschiedlich. Demgegen\u00fcber waren die n10-Amplitude rechts und der LSD-Parameter nicht signifikant unterschiedlich. Alle n10-Latenzen und das AR sowie alle Parameter aus der neuen Analyse waren signifikant unterschiedlich zwischen den Gruppen.<\/jats:p><jats:p>Die vorliegende Studie best\u00e4tigt die zum einen schon bekannten Ver\u00e4nderungen in der Registrierung von oVEMPs bei Patienten mit MS gegen\u00fcber gesunden Probanden, und zum anderen haben die neuen Parameter das Potenzial, den aktuellen Krankheitszustand besser zu beschreiben und detaillierte Informationen \u00fcber den aktuellen Zustand der Myelinisierung bzw. die Lokalisierung der pathophysiologischen Prozesse im ZNS zu geben.<\/jats:p>","DOI":"10.1055\/a-2520-3439","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T18:40:35Z","timestamp":1740076835000},"page":"498-504","source":"Crossref","is-referenced-by-count":1,"title":["Ver\u00e4nderte neuronale Verarbeitung von oVEMPs bei Patienten mit Multiple Sklerose"],"prefix":"10.1055","volume":"104","author":[{"given":"Lisa","family":"Schulte-G\u00f6bel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Linxweiler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Fassbender","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Universit\u00e4tsklinikum des Saarlandes Klinik f\u00fcr Neurologie, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Fousse","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Universit\u00e4tsklinikum des Saarlandes Klinik f\u00fcr Neurologie, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Walter","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Universit\u00e4tsklinikum des Saarlandes Klinik f\u00fcr Neurologie, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Bozzato","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schick","sequence":"additional","affiliation":[{"name":"Fachbereich f\u00fcr HNO-Heilkunde, Universit\u00e4t des Saarlandes Medizinische Fakult\u00e4t, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Hecker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1056\/NEJMra052130","article-title":"Multiple sclerosis\u2014the plaque and its pathogenesis","volume":"354","author":"EM Frohman","year":"2006","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"ref2","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/nrneurol.2012.198","article-title":"The initiation and prevention of multiple sclerosis","volume":"8","author":"A Ascherio","year":"2012","journal-title":"Nature Reviews Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"104142","DOI":"10.1016\/j.msard.2022.104142","article-title":"The relationship between stress and disease onset and relapse in multiple sclerosis: A systematic review","volume":"67","author":"J Jiang","year":"2022","journal-title":"Multiple Sclerosis and Related Disorders"},{"issue":"04","key":"ref4","first-page":"188","article-title":"Value of visual evoked potentials and cerebrospinal fluid in the clinical diagnosis of multiple sclerosis. 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